Essential Biochemistry, International Adaptation

CHARLOTTE PRATT received a B.S. in biology from the University of Notre Dame and a Ph.D. in biochemistry from Duke University. She is a protein chemist who has conducted research in blood coagulation and inflammation at the University of North Carolina at Chapel Hill. She is currently Associate Professor in the Biology Department at Seattle Pacific University. Her interests include molecular evolution, enzyme action, and the relationship between metabolic processes and disease. She has written numerous research and review articles, has worked as a textbook editor, and is a co-author, with Donald Voet and Judith G. Voet, of Fundamentals of Biochemistry, published by John Wiley & Sons, Inc.KATHLEEN CORNELY holds a B.S. in chemistry from Bowling Green (Ohio) State University, an M.S. in biochemistry from Indiana University, and a Ph.D. in nutritional biochemistry from Cornell University. She is currently the Robert H. Walsh '39 Endowed Professor in Chemistry and Biochemistry at Providence College, where she has focused on expanding the use of case studies and guided inquiry across a broad spectrum of classes. Her interest in active pedagogy has led to her involvement in national programs including Project Kaleidoscope, the POGIL Project, and the Howard Hughes Medical Institute SEA PHAGES program, which has also fueled her current experimental research in phage genomics. She has been a member of the editorial board of Biochemistry and Molecular Biology Education and has served for several years as coordinator of the undergraduate poster competition at the annual meeting of the American Society for Biochemistry and Molecular Biology.

• Preface xvPart 1 Foundations12 Metabolism and Bioenergetics 3511 The Chemical Basis of Life 12 Aqueous Chemistry 27Part 2 Molecular Structure and Function3 Nucleic Acid Structure and Function 574 Amino Acid and Protein Structure 875 Protein Function 1276 Enzymes: Classification and Catalysis 1697 Enzyme Kinetics and Inhibition 2038 Lipids and Biological Membranes 2419 Membrane Transport 26910 Signaling 29911 Carbohydrates 327Part 3 Metabolism12 Metabolism and Bioenergetics 35113 Carbohydrate Metabolism 38114 The Citric Acid Cycle 41915 Oxidative Phosphorylation 44316 Photosynthesis 47317 Lipid Metabolism 49918 Nitrogen Metabolism 53519 Regulation of Mammalian Fuel Metabolism 571Part 4 Genetic Information20 DNA Replication and Repair 59721 Transcription and RNA Processing 64122 Protein Synthesis 677