The National Institutes of Health Women's Health Initiative (WHI) is the largest research study ever funded by NIH ($625 million over 14 years) and is designed to test strategies to prevent cardiovascular disease, breast cancer, and osteoporotic fractures--leading causes of death, disability, and decreased quality of life for older women. Although the WHI has already begun, serious questions remain about its design, cost, and the likelihood that it can answer the questions it asks. This book evaluates whether the effort can be justified scientifically.
Susan Thaul and Dana Hotra, Editors; Committee to Review the NIH Women's Health Initiative, Institute of Medicine
1 Front Matter; 2 Executive Summary; 3 Introduction; 4 Clinical Trial; 5 Observational Study; 6 Community Prevention Study; 7 Concluding Remarks; 8 References; 9 Appendix A: Clinical Trial Exclusion Criteria; 10 Appendix B: U.S. House of Representatives Appropriations COmmittee; 11 Appendix C: Statement of Task; 12 Appendix D: Documents Received by the Institute of Medicine from the National Institutes of Health; 13 Appendix E: Meeting Participants June, July, and August 1993; 14 Appendix F: Primary and Subsidiary Hypotheses of the Women's Health Initiative Clinical Trial; 15 Appendix G: Women's Health Initiative Committees; 16 Appendix H: NIH-Sponsored Women's Health Studies; 17 Appendix I: NIH Cost and FTE Summary for Vanguard Clinical Centers; 18 Appendix J: NIH Power Calculations; 19 Appendix K: Women's Health Initiative Clinical Coordinating Center and Vanguard Clinical Centers Principal Investigators; 20 Appendix L: Abbreviations and Acronyms; 21 Appendix M: Committee and Staff Biographies
National Research Council, Division of Behavioral and Social Sciences and Education, Institute of Medicine, and Families Board on Children, Youth, Steve Olson
Institute of Medicine, Board on the Health of Select Populations, and Transgender Health Issues and Research Gaps and Opportunities Committee on Lesbian, Gay, Bisexual
Institute of Medicine, Board on Population Health and Public Health Practice, Division of Health Promotion and Disease Prevention, Division of International Health
Institute of Medicine, Committee to Develop Methods Useful to the Department of Veteran Affairs in Estimating Its Physician Requirements, Joseph Lipscomb
Institute of Medicine, Medical Follow-up Agency, Committee to Study the Mortality of Military Personnel Present at Atmospheric Tests of Nuclear Weapons, Heather O'Maonaigh, Harriet Crawford, William F. Page, Susan Thaul
Institute of Medicine, Medical Follow-Up Agency, and Chemicals in U.S. Military Forces Committee to Study the Interactions of Drugs, Biologics, Susan Thaul, William F. Page, Robert G. Petersdorf
Institute of Medicine, Medical Follow-up Agency, Committee on a Strategy for Minimizing the Impact of Naturally Occurring Infectious Diseases of Military Importance: Vaccine Issues in the U.S. Military, Heather C. O'Maonaigh, Salem Fisseha, Susan Thaul, Stanley M. Lemon