New Vaccine Development

Division of Health Promotion and Disease Prevention, Division of International Health

• 1 Front Matter; 2 1. Summary; 3 2. Priority Setting for Health-Related Investments: A Review of Methods; 4 3. Overview of the Analytic Approach; 5 4. Comparison of Disease Burdens; 6 5. Predictions of Vaccine Development; 7 6. Assessing the Likely Utilization of New Vaccines; 8 7. Calculation and Comparison of the Health Benefits and Differential Costs Associated with Candidate Vaccines; 9 8. Additional Issues in the Selection of Priorities for Accelerated Vaccine Development; 10 9. Findings, Conclusions, and Recommendations; 11 Appendix A: Selection of Vaccine Candidates for Accelerated Development; 12 Appendix B: The Burden of Disease Resulting from Acute Respiratory Illness; 13 Appendix C: The Burden of Disease Resulting from Diarrhea; 14 Appendix D-1: The Prospects for Immunizing Against Dengue Virus; 15 Appendix D-2: The Prospects for Immunizing Against Escherichia coli; 16 Appendix D-3: The Prospects for Immunizing Against Hemophilus influenzae Type b; 17 Appendix D-4: The Prospects for Immunizing Against Hepatitis A Virus; 18 Appendix D-5: The Prospects for Immunizing Against Hepatitis B Virus; 19 Appendix D-6: The Prospects for Immunizing Against Japanese Encephalitis Virus; 20 Appendix D-7: The Prospects for Immunizing Against Mycobacterium leprae; 21 Appendix D-8: The Prospects for Immunizing Against Neisseria meningitidis; 22 Appendix D-9: The Prospects for Immunizing Against Parainfluenza Viruses; 23 Appendix D-10: The Prospects for Immunizing Against Plasmodium spp; 24 Appendix D-11: The Prospects for Immunizing Against Rabies Virus; 25 Appendix D-12: The Prospects for Immunizing Against Respiratory Syncytial Virus; 26 Appendix D-13: The Prospects for Immunizing Against Rotavirus; 27 Appendix D-14: The Prospects for Immunizing Against Salmonella typhi; 28 Appendix D-15: The Prospects for Immunizing Against Shigella spp; 29 Appendix D-16: The Prospects for Immunizing Against Streptococcus Group A; 30 Appendix D-17: The Prospects for Immunizing Against Streptococcus pneumoniae; 31 Appendix D-18: The Prospects for Immunizing Against Vibrio cholerae; 32 Appendix D-19: The Prospects for Immunizing Against Yellow Fever; 33 Appendix E: Questionnaire for Assessing Morbidity-Mortality Trade-Offs; 34 Appendix F: Technical Notes; 35 Appendix G: Biographical Notes on Committee Members; 36 Appendix H: Additional Sources of Advice to the Committee; 37 Appendix I: Contents of Supplement to Volume II; 38 Appendix J: Preface to Volume I; 39 Appendix K: Contents to Volume I; 40 Index