Ageing Vulnerability

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

• Symposium on Ageing vulnerability: causes and interventions, held at the Novartis Foundation,London, 29 February^3 March 2000Editors: Gregory Bock (Organizer) and Jamie A. GoodeThis symposium is based on a proposal made by Gary Andrews. It was organized as a key component and in support of the United Nations Project ‘A Research Agenda on Ageing for the 21st Century’Thomas B. L. Kirkwood Introduction 1Gary R. Andrews The priority of basic research on ageing vulnerability in a comprehensive research agenda on ageing for the 21st century 4Discussion 9Julie K. Andersen Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson’s disease? 11Discussion 20Ashley I. Bush and Lee E. Goldstein Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer’s disease and age-related cataracts 26Discussion 38General discussion I The role of glial cells in the ageing brain 44R.N. Kalaria, C.G. Ballard, P.G. Ince, R.A. Kenny, I.G. McKeith, C.M. Morris, J.T. O’Brien, E. K. Perry, R.H. Perry and J. A. Edwardson Multiple substrates of late-onset dementia: implications for brain protection 49Discussion 60C. S. Potten, K. Martin and T. B. L. Kirkwood Ageing of murine small intestinal stem cells 66Discussion 79Amiela Globerson Haematopoietic stem cell ageing 85Discussion 96General discussion II 101James K. Leung and Olivia M. Pereira-Smith Identification of genes involved in cell senescence and immortalization: potential implications for tissue ageing 105Discussion 110Jerry W. Shay and Woodring E.Wright Ageing and cancer: the telomere and telomerase connection 116Discussion 125Rita B. E¡ros Ageing and the immune system 130Discussion 139General discussion III 146Lis Mosekilde Mechanisms of age-related bone loss 150Discussion 166Edward G. Lakatta, Steven J. Sollott and Salvatore Pepe The old heart: operating on the edge 172Discussion 196Anthony Cerami and Peter Ulrich Pharmaceutical intervention of advanced glycation end products 202Discussion 212General discussion IV 217Holly Van Remmen, Zhongmao Guo and Arlan Richardson The anti-ageing action of dietary restriction 221Discussion 230D. A. Cottrell, E. L. Blakely, M. A. Johnson, G.M. Borthwick, P. I. Ince and D. M. Turnbull Mitochondrial DNA mutations in disease and ageing 234Discussion 243Douglas C. Wallace A mitochondrial paradigm for degenerative diseases and ageing 247Discussion 263Final discussion 267Index of contributors 273Subject index 275