Del 235 - Novartis Foundation Symposia

Ageing Vulnerability

Causes and Interventions

Inbunden, Engelska, 2001

AvGregory R. Bock,Jamie A. Goode,Gregory R Bock,Jamie A Goode

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With the ever-increasing rise in life expectancy, there is an urgent need to improve our understanding of the relationship between ageing and the pathogenesis of age-related diseases in order to identify more effective means of prevention, amelioration and management of such diseases. In addition, there is a need to reduce the social and economic impact of the ageing population. Age-related morbidity and mortality vary dramatically among individuals; this book focusses on individual differences in susceptibility to age-related disorders. It contains contributions from leading experts in the field on topics such as:age-related pathology in the brain, age-related processes in stem cells, and age-related effects on the immune system and in bone, muscle and cardiovascular tissue.For all those with an interest in the biology of ageing, this is compulsory reading.

Produktinformation

Utgivningsdatum2001-02-19
Mått158 x 238 x 19 mm
Vikt567 g
FormatInbunden
SpråkEngelska
SerieNovartis Foundation Symposia
Antal sidor300
FörlagJohn Wiley & Sons Inc
ISBN9780471494386

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Symposium on Ageing vulnerability: causes and interventions, held at the Novartis Foundation,London, 29 February^3 March 2000Editors: Gregory Bock (Organizer) and Jamie A. GoodeThis symposium is based on a proposal made by Gary Andrews. It was organized as a key component and in support of the United Nations Project ‘A Research Agenda on Ageing for the 21st Century’Thomas B. L. Kirkwood Introduction 1Gary R. Andrews The priority of basic research on ageing vulnerability in a comprehensive research agenda on ageing for the 21st century 4Discussion 9Julie K. Andersen Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson’s disease? 11Discussion 20Ashley I. Bush and Lee E. Goldstein Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer’s disease and age-related cataracts 26Discussion 38General discussion I The role of glial cells in the ageing brain 44R.N. Kalaria, C.G. Ballard, P.G. Ince, R.A. Kenny, I.G. McKeith, C.M. Morris, J.T. O’Brien, E. K. Perry, R.H. Perry and J. A. Edwardson Multiple substrates of late-onset dementia: implications for brain protection 49Discussion 60C. S. Potten, K. Martin and T. B. L. Kirkwood Ageing of murine small intestinal stem cells 66Discussion 79Amiela Globerson Haematopoietic stem cell ageing 85Discussion 96General discussion II 101James K. Leung and Olivia M. Pereira-Smith Identification of genes involved in cell senescence and immortalization: potential implications for tissue ageing 105Discussion 110Jerry W. Shay and Woodring E.Wright Ageing and cancer: the telomere and telomerase connection 116Discussion 125Rita B. E¡ros Ageing and the immune system 130Discussion 139General discussion III 146Lis Mosekilde Mechanisms of age-related bone loss 150Discussion 166Edward G. Lakatta, Steven J. Sollott and Salvatore Pepe The old heart: operating on the edge 172Discussion 196Anthony Cerami and Peter Ulrich Pharmaceutical intervention of advanced glycation end products 202Discussion 212General discussion IV 217Holly Van Remmen, Zhongmao Guo and Arlan Richardson The anti-ageing action of dietary restriction 221Discussion 230D. A. Cottrell, E. L. Blakely, M. A. Johnson, G.M. Borthwick, P. I. Ince and D. M. Turnbull Mitochondrial DNA mutations in disease and ageing 234Discussion 243Douglas C. Wallace A mitochondrial paradigm for degenerative diseases and ageing 247Discussion 263Final discussion 267Index of contributors 273Subject index 275