Advances in Immunology

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

• 1. Multilayer regulation of CD4 T cell subset differentiation in the era of single cell genomicsWaradon Sungnak, Chao Wang and Vijay K. Kuchroo2. Transcription factories in Igκ allelic choice and diversitySophiya Karki, Shiladitya Banerjee, Kaitlin Mclean, Aaron Dinner and Marcus R. Clark3. Cis- and trans-factors affecting AID targeting and mutagenic outcomes in antibody diversificationLeng-Siew Yeap and Fei-Long Meng4. Signaling control of antibody isotype switchingZhangguo Chen and Jing H. Wang