Advances in Immunology

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

• 1. The design of vaccine strategies to elicit HIV-1 broadly neutralizing antibodiesJoseph Jardine2. T cells in latent viral infectionsDietmar Zehn3. Preserving Immune Homeostasis with A20Averil Ma4. Transcriptional control in the context of innate and adaptive lymphoid developmentBarbara Kee5. RAG and AID structural biology and the important insights it has generated for the V(D)J recombination and CSR/SHM fieldsHeng Ru6. The advancing area of the mechanisms involved in the evolution of HIV-1 neutralizing antibodiesMattia Bonsignori7. Normal Microbiota inducing disease Martin Kriegel8. Plasma Cell Sub-populationsWolfgang Schuh