Advances in Immunology

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

• Transcriptional regulation in neutrophils: Teaching old cells new tricksTumor vaccinesImmunotherapy of allergic diseaseInteractions of immunoglobulins outside the antigen-combining siteThe role of antibodies in mouse models of rheumatoid arthirits, and relevance to human diseaseMUC1 Immunobiology: from discovery to clinical applications Human models of inherited immunoglobulin class switch recombination and somatic hypermutation defects (Hyper-IgM syndromes)The Biologic Role of C1 Inhibitor in Regulation of Vascular Permeability and Modulation of Inflammation