Distinguished Senior Investigator, Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.), Madrid, Spain. Emeritus Professor of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan. Dr Jalife is also actively conducting research at the Centro Nacional de Investigaciones Cardiovasculares, in Madrid, Spain. William Gregory Stevenson, MD, is Professor of Medicine at Vanderbilt University School of Medicine in Nashville, Tennessee. Dr Jalife will assume the role of lead editor on the 8th edition with Douglas Zipes's retirement

• Section 1 STRUCTURAL AND MOLECULAR BASES OF ION CHANNEL FUNCTION1. Voltage-gated sodium channels and electrical excitability of the heart2. Voltage-gated calcium3. Voltage-gated potassium channels4. Structural and molecular bases of cardiac inward rectifier potassium channel function5. Mammalian calcium pumps in health and disease6. Structural and molecular bases of sarcoplasmic reticulum ion channel function7. Organellar ion channels and transporters8. Molecular organization, gating, and function of connexin-based gap junction channels and hemichannelsSection 2 BIOPHYSICS OF CARDIAC ION CHANNEL FUNCTION9. Structure-function relations of heterotrimetric complexes of sodium channel a and ? subunits10. Regulation of cardiac calcium channels11. Inhibition of phosphoinositide 3-kinase and acquired long QT syndrome12. Structural determinants and biophysical properties of hERG1 channel gating13. Molecular regulation of cardiac inward rectifier potassium channels by pharmacologic agents14. Cardiac stretch-activated channels and mechano-electric coupling15. Biophysical properties of gap junctions16. Excitation-contraction couplingSection 3 INTERMOLECULAR INTERACTIONS AND CARDIOMYOCYTE ELECTRICAL FUNCTION17. Ion channel trafficking in the heart18. Microdomain interactions of macromolecular complexes and regulation of the sodium channel nav1.519. Fibroblast growth factor homologous factors modulate cardiac calcium channels20. Macromolecular complexes and cardiac potassium channels21. Reciprocity of cardiac sodium and potassium channels in the control of excitability and arrhythmias22. The intercalated disc: A molecular network that integrates electrical coupling, intercellular adhesion and cell excitability23. Function and dysfunction of ion channel membrane trafficking and post translational modification24. Feedback mechanisms for cardiac-specific microRNAs and cAMP signaling in electrical remodelingSection 4 CELL BIOLOGY OF CARDIAC IMPULSE INITIATION AND PROPAGATION25. Stem cell-derived nodal-like cardiomyocytes as a novel pharmacologic tool: Insights from sinoatrial node development and function26. Gene therapy and biologic pacing27. Intercellular communication and impulse propagation28. Mechanisms of normal and dysfunctional sinoatrial nodal excitability and propagation29. Cell biology of the specialized cardiac conduction system30. Cardiac remodeling and regenerationSection 5 MODELS OF CARDIAC EXCITATION31. Ionic mechanisms of atrial action potentials32. Genetic algorithms to generate dynamical complexity electrophysiological models33. Calcium signaling in cardiomyocyte dodels with realistic geometries34. Theory of rotors and arrhythmias35. Computational approaches for accurate rotor localization in the human atria36. Modeling the aging heartSection 6 NEURAL CONTROL OF CARDIAC ELECTRICAL ACTIVITY37. Innervation of the sinoatrial node38. Mechanism for altered autonomic and oxidant regulation of cardiac sodium currents.39. Pulmonary vein ganglia and the neural regulation of the heart rate40. Neural activity and atrial tachyarrhythmias41. Sympathetic innervation and cardiac arrhythmiasSection 7 ARRHYTHMIA MECHANISMS42. The molecular pathophysiology of atrial fibrillation43. Myofibroblasts, cytokines, and persistent atrial fibrillation44. Role of the autonomic nervous system in atrial fibrillation45. Rotors in human atrial fibrillation46. Body surface frequency-phase mapping of atrial fibrillation47. Panoramic mapping of atrial fibrillation from the body surface48. Mechanisms of human ventricular tachycardia and human ventricular fibrillation49. Genetics of atrial fibrillationSection 8 MOLECULAR GENETICS AND PHARMACOGENOMICS50. Mechanisms in heritable sodium channel diseases51. Genetic, ionic, and cellular mechanisms underlying the J-wave syndromes52. Inheritable potassium channel diseases53. Inheritable phenotypes associated with altered intracellular calcium regulationSection 9 PHARMACOLOGIC, GENETIC, AND CELL THERAPY OF ION CHANNEL DYSFUNCTION54. Pharmacologic bases of antiarrhythmic therapy55. Pharmacogenomics of cardiac arrhythmias56. Gene therapy to treat cardiac arrhythmias57. Highly mature human iPSC-derived cardiomyocytes as models for cardiac electrophysiology and drug testing58. Cardiac repair with human induced pluripotent stem cell-derived cardiovascular cells.Section 10 DIAGNOSTIC EVALUATION59. Assessment of the patient with a cardiac arrhythmia60. Electrocardiography of tachyarrhythmias: Differential diagnosis of narrow and wide QRS complex tachycardias61. Electroanatomic mapping for arrhythmias62. Computed tomography for electrophysiology63. Magnetic resonance imaging for electrophysiology64. Intracardiac echocardiography for electrophysiology65. Exercise-induced arrhythmias66. Cardiac monitoring: short- and long-term recording67. Head-up tilt table testing68. Autonomic regulation and cardiac risk69. T-wave alternans70. Noninvasive electrocardiographic imaging of human ventricular arrhythmias and Electrophysiological Substrate71. Genetic testingSection 11 SUPRAVENTRICULAR TACHYARRHYTHIAS: MECHANISMS, CLINICAL FEATURES, AND MANAGEMENT72. Sinus node abnormalities73. Atrial tachycardia74. Atrial tachycardia in adults with congenital heart disease75. Typical and atypical atrial flutter: Mapping and ablation76. Atrial fibrillation77. Preexcitation, atrioventricular reentry, variants78. Electrophysiological characteristics of atrioventricular nodal reentrant tachycardia: Implications for the rentrant circuits79. Junctional tachycardiaSection 12 VENTRICULAR TACHYCARRHYTHMIAS: MECHANISMS, CLNICAL FEATURES, AND MANAGEMENT80. Premature ventricular complexes81. Outflow tract ventricular tachycardias: Mechanisms, clinical features, and management82. Fascicular ventricular arrhythmias83. Bundle branch reentry tachycardia84. Ischemic heart disease85. Ventricular tachycardia in patients with dilated cardiomyopathy86. Ventricular arrhythmias in hypertrophic cardiomyopathy87. Ventricular tachycardias in arrhythmogenic right ventricular dysplasia/cardiomyopathy88. VTs in catcholaminergic cardiomyopathy (catecholaminergic polymorphic ventricular tachycardia)89. Ventricular arrhythmias in heart failure90. Arrhythmias and conduction disturbances in non-compaction cardiomyopathy91. Takotsubo cardiomyopathy92. Brugada syndrome93. Long and short QT syndromes94. Anderson-Tawil syndrome95. Timothy syndrome96. J-wave syndromes97. Idiopathic ventricular fibrillation98. Sudden infant death syndrome99. Sudden cardiac arrest/death in adults100. Neurologic disorders101. Drug-induced ventricular tachycardia102. Ventricular arrhythmias in congenital heart diseaseSection 13 SYNCOPE AND BRADYARRHYTHMIAS103. Syncope104. Postural orthostatic tachycardia syndrome105. Progressive conduction system disease106. Atrioventricular blockSection 14 ARRHYTHMIAS IN SPECIAL POPULATIONS PHARMACOLOGIC THERAPY107. Sex differences in arrhythmias108. Sudden cardiac death in athletes, including commotio cordis109. Pediatric populations110. Sleep-disordered breathing and arrhythmias111. Ventricular assist devices and cardiac transplantation recipientsSection 15 PHARMACOLOGIC THERAPY112. Standard antiarrhythmic drugs113. Innovations in antiarrhythmic drug therapy114. Nontraditional drugs for sudden cardiac death115. Prevention of stroke in atrial fibrillation: warfarin, anti-factor Xa and thrombin drugsSection 16 CARDIAC IMPLANTABLE ELECTRONIC DEVICES116. Implantable cardioverter defibrillators: technical aspects117. Implantable cardioverter defibrillators: clinical aspects118. Subcutaneous implantable defibrillator119. Implantable pacemakers120. Cardiac resynchronization therapy121. Newer applications of pacemakers122. Remote monitoringSection 17 CATHETER ABLATION123. Catheter ablation: Technical aspects124. Catheter ablation: Clinical aspects125. Ablation for atrial fibrillation126. Ablation of supraventricular tachycardias127. Catheter ablation for ventricular tachycardias with/without structural heart disease128. Epicardial and other approaches129. Ventricular fibrillation130. Ablation in pediatrics131. Congenital heart disease132. Anesthesiology for EP proceduresSection 18: SURGERY FOR ARRHYTHMIAS133. Surgery for atrial fibrillation and other supraventricular tachycardias134. Surgery for ventricular tachycardiaSection 19 NEW APPROACHES135. Cervical vagal stimulation for heart failure136. Baroreflex stimulation137. Spinal cord stimulation for heart failure and arrhythmias138. Renal artery denervation139. Left atrial appendage occlusion/ligation

"The quality of the content of this book is excellent. Given the complexity of the subject manner, this book is a valuable resource for cardiologists and cardiology fellows with a specific interest in electrophysiology, as well as for electrophysiologists and electrophysiology fellows to further their knowledge and understanding of the complex topic of electrophysiology. The book is organized in a way that allows readers to develop an advancing framework that enables them to build upon and better grasp more advanced topics. The eighth edition provides updated knowledge and treatment strategies based on up-to-date research that was not in the previous edition." --©Doody’s Review Service, 2022, Matthew Alan Colna, MD (East Tennessee State University Quillen College of Medicine) Doody's Score: 5 Stars!