Beginning in the early 1980s, new technologies, began to permit evaluation of the expression of individual genes. Recent technological advances have expanded those evaluations to permit the simultaneous detection of the expression of tens of thousands of genes and to support holistic evaluations of the entire genome. The application of these technologies has enabled researchers to unravel complexities of cell biology and, in conjunction with toxicologic evaluations, the technologies are used to probe and gain insight into questions of toxicologic relevance. As a result, the use of the technologies has become increasingly important for scientists in academia, as well as for the regulatory and drug development process.
Committee on Validation of Toxicogenomic Technologies: A Focus on Chemical Classification Strategies, Committee on Emerging Issues and Data on Environmental Contaminants, National Research Council
1 Front Matter; 2 Summary of the Workshop; 3 Attachment 1. Experimental Objectives of DNA Microarray Studies; 4 Attachment 2. Comparison of Microarray Data from Multiple Labs and Platforms; 5 Attachment 3. Statistical Analysis of Toxicogenomic Microarray Data; 6 Attachment 4. Diagnostic Classifier - Gaining Confidence Through Validation; 7 Appendix A: Workshop Planning Committee Biographical Information; 8 Appendix B: Workshop Agenda; 9 Appendix C: Federal Liaison Group for the NRC Committee on Emerging Issues and Data on Environmental Contaminants
National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Committee on Metagenomics: Challenges and Functional Applications
National Research Council, Division of Behavioral and Social Sciences and Education, Institute of Medicine, and Families Board on Children, Youth, Steve Olson
National Research Council, Division on Earth and Life Studies, Board on Agriculture and Natural Resources, Committee on Animal Nutrition, Subcommittee on Dog and Cat Nutrition
National Research Council, Division on Earth and Life Studies, Board on Agriculture and Natural Resources, Committee on Nutrient Requirements of Horses
National Research Council, Division of Behavioral and Social Sciences and Education, Commission on Behavioral and Social Sciences and Education, and Statistical Sciences Committee on AIDS Research and the Behavioral, Social, Lincoln E. Moses, Heather G. Miller, Charles F. Turner
National Research Council, Division on Earth and Life Studies, Environment and Resources Commission on Geosciences, Board on Environmental Studies and Toxicology, Committee to Review the Outer Continental Shelf Environmental Studies Program, Ecology Panel
National Research Council, Division on Engineering and Physical Sciences, Commission on Engineering and Technical Systems, Committee on Alternative Chemical Demilitarization Technologies
National Research Council, Division on Earth and Life Studies, Environment and Resources Commission on Geosciences, Panel on Effects of Past Global Change on Life
National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Emerging Issues and Data on Environmental Contaminants, Committee on Applications of Toxicogenomics to Cross-Species Extrapolation
National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Committee on Emerging Issues and Data on Environmental Contaminants, Committee on How Toxicogenomics Could Inform Critical Issues in Carcinogenic Risk Assessment of Environmental Chemicals
and Medicine National Academies of Sciences, Engineering, Division on Earth and Life Studies, Board on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Research at Multiple Scales: A Vision for Continental Scale Biology
and Medicine National Academies of Sciences, Engineering, Division on Earth and Life Studies, Board on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Advancing Understanding of the Implications of Environmental-Chemical Interactions with the Human Microbiome
and Medicine National Academies of Sciences, Engineering, Health and Medicine Division, Division on Earth and Life Studies, Board on Life Sciences, Board on Global Health, Board on Environmental Studies and Toxicology, Board on Atmospheric Sciences and Climate, Julie Liao, Joe Alper
National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology
and Medicine National Academies of Sciences, Engineering, National Academy of Engineering, Division on Engineering and Physical Sciences, Division on Earth and Life Studies, Water Science and Technology Board, Ocean Studies Board, NAE Office of Programs, Board on Life Sciences, Board on Environmental Studies and Toxicology, Board on Earth Sciences and Resources, Board on Energy and Environmental Systems, Board on Chemical Sciences and Technology, Board on Atmospheric Sciences and Climate, Board on Agriculture and Natural Resources, Committee on the Grand Challenges and Opportunites in Environmental Engineering for the Twenty-First Century
and Medicine National Academies of Sciences, Engineering, Division on Earth and Life Studies, Board on Life Sciences, Board on Environmental Studies and Toxicology, Board on Chemical Sciences and Technology, Committee on Costs and Approaches for Municipal Solid Waste Recycling Programs
and Medicine National Academies of Sciences, Engineering, National Academy of Engineering, Division on Engineering and Physical Sciences, Health and Medicine Division, Division on Earth and Life Studies, Board on Infrastructure and the Constructed Environment, Board on Environmental Studies and Toxicology, Board on Life Sciences, Committee on Microbiomes of the Built Environment: From Research to Application
and Medicine National Academies of Sciences, Engineering, Division on Earth and Life Studies, Board on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures