Tumor Dormancy, Quiescence, and Senescence, Volume 1

Aging, Cancer, and Noncancer Pathologies

Häftad, Engelska, 2016

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With a particular emphasis on tumor dormancy in breast, lung, prostate, and liver cancers, as well as in melanoma, this first volume of a new Springer series focuses on the interrelationship between biological processes of aging and tumors—both dormant and quiescent.

Produktinformation

Utgivningsdatum2016-08-23
Mått178 x 254 x 19 mm
Vikt612 g
FormatHäftad
SpråkEngelska
SerieTumor Dormancy and Cellular Quiescence and Senescence
Antal sidor324
FörlagSpringer
ISBN9789402407020

Tillhör följande kategorier

Onkologi inom Medicin
Samhällsmedicin och preventiv medicin inom Medicin
Biologi inom Naturvetenskap och teknik

Preface.-I. Tumor dormancy.- Is tumor dormancy clinically relevant?- Microenvironmental influence on breast cancer Dormancy and metastasis.- Determination of breast cancer dormancy: analysis of Circulating free dna using snp 6.0 arrays.- Clonogenicity of cultured prostate cancer cells is controlled by dormancy : significance and comparison with cell culture models of breast cancer cell dormancy.- Dormancy and metastasis of melanoma cells to lymph Nodes, lung, and liver.- Late recurrence is a sign of melanoma dormancy: need of Life-long follow-up of elanoma patients. II. Quiescence.- Hematopoietic stem cell quiescence and long term Maintenance: role of scl/tal1.- Regulation of muscle stem cell quiescent and Undifferentiated state: roles of hesr1 and hesr3 genes.- The kinase mirk/dyrk1b mediates a reversible quiescent State in a subset of ovarian, pancreatic, and colon cancers. III. Cellular senescence.- Stress -induced senescence: molecular pathways.-11 Accumulation of reactive oxygen species and induction Of premature senescence: role of ddb2.- P21 mediates senescence by a mechanism involving accumulation of reactive oxygen species.- Role of micrornase and zeb1 downmodulation in oxidative Stress-induced apoptosis and senescence.- Hypoxic response in senescent brain is impaired: possible Contribution to neurodegeneration.-Enhancing reprogramming to pluripotency by controlling senescence.- Histone deacetylase inhibitor induces replicative Senescence of mesenchymal stem cells.- Senescence arrest of endopolyploid cells renders Senescence into one mechanism for positive tumorigenesis.- The two faces of senescence-associated epigenetic Alterations: tumor suppressors and oncogenic drivers.- Chemotherapy- and radiation-induced accelerated senescence: implications for treatment response, tumor progression, and cancer survivorship.- Suppression of cellular senescence in glioblastoma: role Of src homology domain-containing phosphatase 2.- Chemotherapy ofmalignant pleural mesothelioma induces both senescence and apoptosis.- Microrna as a modulator of cell proliferation and Senescence: role in lung cancer cells.- Role of senescence induction in cancer therapy .- Cellular senescence limits the extent of fibrosis Following liver damage.- Formation of secretory senescent cells in prostate tumors: the role of androgen receptor activity and cell cycle regulation.-Index