James Ritter, Professor of Clinical Pharmacology at King's College London School of Medicine, Guy's, King's and St Thomas' Hospitals, London, UKLionel Lewis, Professor of Medicine, Pharmacology and Toxicology at Dartmouth Medical School, Lebanon, New Hampshire, USA Tim Mant, Senior Medical Advisor at Quintiles, Guy's Drug Research Unit, and Visiting Professor at King's College London School of Medicine, Guy's, King's and St Thomas' Hospitals, London, UKAlbert Ferro, Reader in Clinical Pharmacology at King's College London School of Medicine, Guy's, King's and St Thomas' Hospitals, London, UK