Regulatory Mechanisms of Striated Muscle Contraction

• Historical Aspects.- Biological Actions of Calcium.- Professor Ebashi’s Journey Toward the Discovery of Troponin: A Personal Recollection.- Highlights of the History of Calcium Regulation of Striated Muscle.- Regulation by Troponin and Tropomyosin.- Troponin: Structure, Function and Dysfunction.- From the Crystal Structure of Troponin to the Mechanism of Calcium Regulation of Muscle Contraction.- Ca Ion and the Troponin Switch.- Disposition and Dynamics: Interdomain Orientations in Troponin.- Structural Basis for Calcium-Regulated Relaxation of Striated Muscles at Interaction Sites of Troponin with Actin and Tropomyosin.- Tropomyosin: Regulator of Actin Filaments.- Tropomyosin and Troponin Cooperativity on the Thin Filament.- Conformational Changes in Reconstituted Skeletal Muscle Thin Filaments Observed by Fluorescence Spectroscopy.- Calcium Structural Transition of Troponin in the Complexes, on the Thin Filament, and in Muscle Fibres, as Studied By Site-Directed Spin-Labelling EPR.- Crystal Structures of Tropomyosin: Flexible Coiled-Coil.- C. Elegans Model for Studying Tropomyosin and Troponin Regulations of Muscle Contraction and Animal Behavior.- Structural and Functional Analysis of Troponins from Scallop Striated and Human Cardiac Muscles.- Regulation in Cardiac Muscle and Disorders.- Cooperativity in the Regulation of Force and the Kinetics of Force Development in Heart and Skeletal Muscles.- Heart Failure, Ischemia/Reperfusion Injury and Cardiac Troponin.- Troponin Mutations in Cardiomyopathies.- Molecular Pathogenic Mechanisms of Cardiomyopathies Caused by Mutations in Cardiac Troponin T.- Cardiac Troponin Levels as a Preferable Biomarker of Myocardial Cell Degradation.- Regulation by Myosin.- Regulation by Myosin: How Calcium Regulates Some Myosins, Past andPresent.- Calcium Inhibition of Physarum Myosin as Examined by the Recombinant Heavy Mero-Myosin.- Excitation-Contraction Coupling and Disorder.- Calcium-Induced Release of Calcium From the Sarcoplasmic Reticulum.- Dysregulation of the Gain of CICR Through Ryanodine Receptor1 (RyR1): The Putative Mechanism Underlying Malignant Hyperthermia.- Ion Pumping by Calcium ATPase of Sarcoplasmic Reticulum.- Regulation of Cell Functions by Ca2+ Oscillation.- Molecular Mechanisms of Muscle Contraction.- Evidence About the Structural Behaviour of Myosin Crossbridges During Muscle Contraction.- Structural Alterations of Thin Actin Filaments in Muscle Contraction by Synchrotron X-ray Fiber Diffraction.- Regulation of Muscle Contraction by Ca2+ and ADP: Focusing on the0 Auto-Oscillation (SPOC).- Muscle Contraction Mechanism Based on Actin Filament Rotation.- On the Walking Mechanism of Linear Molecular Motors.- Modeling of the F-Actin Structure.

From the reviews:"This book comprehensively covers the accumulated knowledge of the regulatory mechanisms controlling striated muscle contraction. The organization and presentation of basic research findings … result in an excellent book that accurately represents the history and current state of the field. … It is written for practitioners of basic and clinical research in the field of striated muscle function and dysfunction. … It contains a wealth of information that is organized in an excellent manner, allowing the reader to quickly locate areas of interest and relevance." (Kristin L. Gosselink, Doody’s Review Service, September, 2008)