Regenerative Nephrology

Michael S. Goligorsky, MD. PhD, holds the Alvin I. Goodman Chair in Nephrology, and is Professor of Medicine, Pharmacology and Physiology and Director of Renal Research Institute at the New York Medical College, Touro University. Dr. Goligorsky serves as an Associate Editor for Am J Pathology and is a member of the Association of American Physicians (elected 2002). His research interests include: the mechanisms of endothelial dysfunction as a harbinger of diabetic, and hypertensive vascular damage; stress-induced premature senescence of endothelial cells and the role of lysosomal dysfunction in this process; mechanisms of functional incompetence of endothelial cells in chronic kidney disease; and mechanisms of alarm signaling by an ischemic kidney.

• PHYLOGENY AND ONTOGENY OF TISSUE REGENERATION1. Glomerulogenesis and de novo nephrogenesis in medaka fish - evolutionary approach Yuko Wakamatsu and Hisashi Hashimoto2. Renal Organogenesis: Growing a replacement kidney in situ from transplanted renal primordia Marc R. Hammerman3. Use of Genetic Mouse Models to study Kidney Regeneration Akio Kobayashi and Jeremy S. DuffieldMEDIATORS OF REGENERATION4. Endogenous Anti-Inflammatory and Pro-Resolving Lipid Mediators in Renal Disease Charles N. Serhan and Catherine Godson5. Tissue protection and regeneration aided by erythropoietin and erythropoietin-derived peptidesDanilo Fliser6. Mast cells in kidney regenerationEric Daugas, Walid Beghdadi and Ulrich Blank7. Role of macrophages in renal injury, repair and regenerationVincent Lee, Qi Cao, Yiping Wang and David C.H. Harris8. T-cells contribution to regenerative processesHamid RabbSTEM CELLS IN REGENERATIVE PROCESSES9. MSC and reparative processesBenjamin D. Humphreys and John V. Bonventre10. Stem cells in regenerative processes: Endothelial progenitor cells and the kidneyMatthieu Monge, Anton J. van Zonneveld and Ton J. Rabelink11. The potential of the side population in regenerative nephrologyMelissa H. Little and G. A. Challen12. Very small embryonic like stem cells (VSELs) and their potential relevance for kidney homeostasisDong-Myung Shin, Rui Liu, Janina Ratajczak, Magda Kucia and Mariusz Z. Ratajczak13. Stem Cells in Regenerative Processes; Induced Pluripotent Stem Cells Kenji Osafune and Shinya Yamanaka14. Methods of Isolation and Culture of Adult Stem cellsLindolfo da Silva Meirelles and Nance Beyer NardiSTEM CELLS - FROM THE NICHE TO REPAIR15. Stem cell niche in the kidney Laura Lasagni, Elena Lazzeri and Paola Romagnani16. Creation of artificial niches Glenn D. Prestwich, Tammer Ghaly, Philip Brudnicki, Brian Ratliff and Michael S. Goligorsky17. Imaging of transplanted and native stem cells Xiang-Yang Zhu, Martin Rodriguez-Porcel and Lilach O. LermanCAUSES OF REGENERATIVE FAILURE16. Stem cell injury and premature senescence Michael S. Goligorsky17. Regeneration and Aging: Regulation by Sirtuins and the NAD+ Salvage PathwayNica M. Borradaile, Alanna Watson, and J. Geoffrey Pickering18. Bone marrow-mesenchymal stem cells in organ repair and strategies to optimize their efficacyChristodoulos Xinaris, Barbara Imberti, Giuseppe Remuzzi and Marina MorigiEMERGING CLINICAL ASPECTS OF STEM CELL THERAPY19. Treatment of Acute Kidney Injury with allogeneic Mesenchymal Stem Cells: Preclinical and initial Clinical DataFlorian E. Tögel and Christof Westenfelder20. Clinical trials in Renal Regenerative MedicineMaarten B. Rookmaaker, Jaap A. Joles and Marianne C. Verhaar21. Potential risks of stem cell therapies Uta Kunter and Jürgen Floege22. Tissue engineering in urology Anthony Atala23. Ethical issues in SC therapy Donald W. Landry24. Stem Cell BankingVicente Mirabet and Pilar Solves

"The authors of Regenerative Nephrology have empowered a group of the leading investigators to provide a comprehensive overview of regenerative processes in the kidney. It spans the subject from cellular physiology to models and the first clinical trials of stem cell therapy. This book fills a gap in this rapidly expanding field. It will be an invaluable reference to the specialist investigator and a useful overview for those in nephrology or regenerative medicine who wish to become fully up to date with this important subject." --Christopher S. Wilcox, MD, PhD, George E. Schreiner Chair of Nephrology,Director, Center for Hypertension, Kidney and Vascular Health, Chief, Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC, USA"Dr. Goligorsky has assembled an outstanding group of authors for his "Regenerative Nephrology" book. The publication of this authoritative work is timely. State-of-the-art knowledge about the phylogeny, ontogeny, and mediators of tissue regeneration is discussed and is critical in pursuing the potential role of stem cells in regenerative processes. The kidney is the organ responsible for total body homeostasis, therefore focusing on regeneration in acute and chronic kidney disease is very appropriate. Moreover, Goligorsky is an internationally prominent researcher in understanding the pathophysiology of kidney disease. Regenerative Nephrology has important sections dealing with the clinical aspects of stem cell therapy including potential risks and ethical issues. I highly recommend this important book, not just for scientists studying the kidney, but for all biomedical scientists, as the dawn of stem cell therapy in humans is emerging for many organs." --Robert W. Schrier, MD, Professor of Medicine, University of Colorado, School of Medicine, Denver, CO, USA"With this book, Dr Goligorsky, along with his impressive collection of highly prominent authors, has certainly succeeded in achieving the goal of bringing an up-to-date review of the basic research of regenerative nephrology and its promising clinical applications to the attention of the interested reader. This is a truly international book; although the majority of the outstanding faculty is North American, excellent contributions have been written by Japanese, Australian and European authors…. This book is not only of interest to the basic expert investigator. Also, the interested teacher or clinician who wants to catch a glimpse of what will become possible in the near future in the treatment of a whole range of acute and chronic kidney diseases with these fascinating new tools will find this book a must…. Dr Goligorsky and his contributors have done a great service to most of us ‘non-experts’ by summarizing, in a brilliant manner, the recent advances in this field." --NDT Plus