Reactivity Tuning in Oligosaccharide Assembly

• Armed–Disarmed Effects in Carbohydrate Chemistry: History, Synthetic and Mechanistic Studies, by Bert Fraser-Reid and J. Cristóbal López: Armed–Disarmed Effects in Carbohydrate Chemistry.- A Survey of Ley’s Reactivity Tuning in Oligosaccharide Synthesis, by Ana M. Gómez.- “Active–Latent” Thioglycosyl Donors and Acceptors in Oligosaccharide Syntheses, by Tze Chieh Shiao and René Roy.- Effect of Electron-Withdrawing Protecting Groups at Remote Positions of Donors on Glycosylation Stereochemistry, by Kwan Soo Kim and Dae-Hwan Suk.- Influence of Protecting Groups on the Reactivity and Selectivity of Glycosylation: Chemistry of the 4,6-O-Benzylidene Protected Mannopyranosyl Donors and Related Species, by Sylvain Aubry, Kaname Sasaki, Indrajeet Sharma and David Crich.- Superarmed and Superdisarmed Building Blocks in Expeditious Oligosaccharide Synthesis, by Hemali D. Premathilake and Alexei V. Demchenko.- Programmable One-Pot Glycosylation, by Chung -Yi Wu and Chi -Huey Wong.- Uronic Acids in Oligosaccharide and Glycoconjugate Synthesis, by Jeroen D. C. Codée, Alphert E. Christina, Marthe T. C. Walvoort, Herman S. Overkleeft and Gijsbert A. van der Marel.-

From the reviews:“In this book, the various concepts that allow a synthetic carbohydrate chemist to make such choices are reviewed. … the various authors describe how the nature of the anomeric leaving group and protecting groups combined with the method of activation allow the fine-tuning of a glycosylation reaction. … this book covers the most important discoveries made recently and should find its place on the bookshelf of any chemist engaged in synthetic carbohydrate chemistry.”­­­ (France-Isabelle Auzanneau, Journal of American Chemical Society, Vol. 133, November, 2011)