Proteomics in Biology, Part B

Dr. Arun K. Shukla is a world leader in the field of GPCR biology and he is currently a Professor in the Department of Biological Sciences and Bioengineering at the Institute of Technology, Kanpur in India. Dr. Shukla’s research program is focused on understanding the structure, function and regulation of G protein-coupled receptors with a long-term of designing novel therapeutics with minimized side-effects.

• 1. Protein Cysteinyl-S-Nitrosylation: Analysis and Quantification2. Quantitative Proteomics of the E. coli Membranome3. Comparative Analysis and Validation of Different Steps in Glycomics Studies4. Analysis of Translocation-Competent Secretory Proteins by HDX-MS5. Site-Specific Quantification of Lysine Acetylation Using Isotopic Labeling6. Posttranslational Modifications and Plant–Environment Interaction7. Identification of Posttranslational Modifications of Endogenous Chromatin Proteins From Testicular Cells by Mass Spectrometry8. Quantitative Analysis of Yeast Checkpoint Protein Kinase Activity by Combined Mass Spectrometry Enzyme Assays9. Retrieving Quantitative Information of Histone PTMs by Mass Spectrometry10. Evaluating Exosome Protein Content Changes Induced by Virus Activity Using SILAC Labeling and LC-MS/MS11. Exoproteomics of Pathogens: Analysis of Toxins and Other Virulence Factors by Proteomics12. Integrated and Quantitative Proteomics of Human Tumors13 .Mass Spectrometry-Based Analysis for the Discovery and Validation of Potential Colorectal Cancer Stool Biomarkers14. Mass Spectrometry-Based Methodology for Identification of Native Histone Variant Modifications From Mammalian Tissues and Solid Tumors15. Drug Target Identification Using an iTRAQ-Based Quantitative Chemical Proteomics Approach—Based on a Target Profiling Study of Andrographolide16. A Super-SILAC Strategy for the Accurate and Multiplexed Profiling of Histone Posttranslational Modifications17. A Comparison of Two-Hybrid Approaches for Detecting Protein–Protein Interactions18. Recent Achievements in Characterizing the Histone Code and Approaches to Integrating Epigenomics and Systems Biology19. Rapid Proteomics to Prospect and Validate Novel Bacterial Metabolism Induced by Environmental Burden20. Quantitation of Human Metallothionein Isoforms in Cells, Tissues, and Cerebrospinal Fluid by Mass Spectrometry21. A Cautionary Tale on the Inclusion of Variable Posttranslational Modifications in Database-Dependent Searches of Mass Spectrometry Data22. Kinase Assay-Linked Phosphoproteomics: Discovery of Direct Kinase Substrates

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