Perinatal programming is one of the most powerful ideas in biology and medicine in the 21st century. Compelling evidence indicates that prevention of childhood and adult diseases must begin during fetal life. Epigenomics has the potential to provide a mechanistic understanding of many phenomena underpinning the developmental origins of health and disease. The book is timely, insightful and of great relevance to obstetrics, perinatal medicine and modern biology. Roberto Romero Chief - Perinatology Research Branch Program Director for Perinatal Research & Obstetrics National Institute of Child Health and Human Development/National Institutes of Health, USA.