Organic Syntheses, Volume 87

Peter Wipf is the Director of the Combinatorial Chemistry Center (CCC) and the Center for Chemical Methodologies and Library Development (UPCMLD) which are involved in many collaborative projects in Chemical Biology. He is also a founding member of the Center for Medical Countermeasures Against Radiation (CMCR) and the University of Pittsburgh Center for Chemical Diversity (UPCDC). He has served on the organizing committee of several conferences and workshops, including the NSF Workshop on Organic Synthesis. He is a member of several editorial boards, including Medicinal Chemistry Letters (ACS MCL), Organic Reactions (OR), and Organic Syntheses (OS).

• Metal-Free One-Pot Oxidative Amination of Aromatic Aldehydes: Conversion of Benzaldehyde to N-Benzoyl Pyrrolidine 1Kekeli Ekoue-Kovi and Christian WolfA Practical and Scalable Synthesis of N-Halo Compounds: 2-Chloro-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline 8Yong-Li Zhong and Paul G. BulgerRegioselective C-4 Bromination of Oxazoles: 4-Bromo-5-(Thiophen-2-YL) Oxazole 16Bryan Li, Richard A. Buzon, and Zhijun ZhangSynthesis of Spiroborate Esters from 1,2-Aminoalcohols, Ethylene Glycol and Triisopropyl Borate: Preparation of (S)-1-(1,3,2-Dioxaborolan-2-Yloxy)-3-Methyl-1,1-Diphenylbutan-2-Amine 26Viatcheslav Stepanenko, Kun Huang and Margarita Ortiz-MarcialesCatalytic Enantioselective Borane Reduction of Benzyl Oximes: Preparation of (S)-1-Pyridin-3-YL-Ethylamine BIS Hydrochloride 36Kun Huang and Margarita Ortiz-MarcialesStereoselective Synthesis of 3-Arylacrylates by Copper-Catalyzed Syn Hydroarylation 53Naohiro Kirai and Yoshihiko YamamotoPreparation of (S)-3,3’-BIS-Morpholinomethyl-5,5’,6,6’,7,7’,8,8’-Octahydro-1,1’-BI-2-Naphthol 59Mark Turlington and Lin PuCatalytic Asymmetric Addition of an In-Situ Prepared Arylzinc to Cyclohexanecarboxaldehyde: (R)-(+)-α-Cyclohexyl-3-Methoxy-Benzenemethanol 68Albert M. DeBerardinis, Mark Turlington, and Lin PuMicrowave-Assisted Synthesis of 1,3-Dimesitylimidazolinium Chloride 77Morgan Hans and Lionel DelaudeSynthesis of (3-Chlorobutyl)Benzene by the Cobalt-Catalyzed Hydrochlorination of 4-Phenyl-1-Butene 88Boris Gaspar, Jerome Waser, and Erick M. CarreiraSynthesis of Substituted Indazoles via (3+2) Cycloaddition of Benzyne and Diazo Compounds 95Feng Shi and Richard C. LarockPalladium-Catalyzed Cross-Coupling Using an Air-Stable Trimethylaluminum Source. Preparation of Ethyl 4-Methylbenzoate 104Andrej Vinogradov and Simon WoodwardSynthesis of Dimethyl 2-Phenycyclopropane-1,1-Dicarboxylate Using an Iodonium Ylide Derived from Dimethyl Malonate 115Sébastien R. Goudreau, David Marcoux and Andre B. CharetteNew, Convenient Route for Trifluoromethylation of Steroidal Molecules 126Xiang-Shu Fei, Wei-Sheng Tian, Kai Ding, Yun Wang and Qing-Yun ChenPreparation of Ethyl 1-Benzyl-4-Fluoropiperidine-4-Carboxylate 137Jianshe Kong, Tao Meng, Pauline Ting, and Jesse WongLithium Amides as Homochiral Ammonia Equivalents for Conjugate Additions to α,ß-Unsaturated Esters: Asymmetric Synthesis of (S)-ß-Leucine 143Stephen G. Davies, Ai M. Fletcher, and Paul M. RobertsCyclohexene Imine (7-Aza-Bicyclo[4.1.0]Heptane) 161Iain D. G. Watson, Nicholas Afagh and Andrei K. YudinPreparation of (E)-(2-Iodovinyl)Benzene From Benzyl Bromide and Diiodomethane 170James A. Bull, James J. Mousseau and André B. CharetteSynthesis of Tetraorganosilanes: (Chloromethyl)Dimethylphenylsilane 178Submitted by Kei Murakami, Hideki Yorimitsu, and Koichiro OshimaA General Method for Copper-Catalyzed Arylation of Acidic Arene C-H Bonds. Preparation of 2-Chloro-5-(3-Methylphenyl)-Thiophene 184Joseph Alvarado, Hien-Quang Do, and Olafs Daugulis1,3,5-Triacetylbenzene 192Peter J. Alaimo, Amanda-Lynn Marshall, David M. Andrews and Joseph M. LangenhanOrganocatalytic α-Methylenation of Aldehydes: Preparation of 3,7-Dimethyl-2-Methylene-6-Octenal 201Meryem Benohoud, Anniina Erkkilä, and Petri M. PihkoRuthenium-Catalyzed Arylation of Ortho C-H Bond in an Aromatic with an Arylboronate: 8-Phenyl-1-Tetralone 209Kentaroh Kitazawa, Takuya Kochi, and Fumitoshi KakiuchiAmide Formation by Decarboxylative Condensation of Hydroxylamines and α-Ketoacids: N-[(1S)-1 Phenylethyl]-Benzeneacetamide 218Lei Ju and Jeffrey W. BodeOne-Pot Diazotization and Heck Reaction of Methyl Anthranilate: 2-(3-Oxopropyl) Benzoic Acid Methyl Ester 226Florencio ZaragozaSynthesis of Ynamides by Copper-Mediated Coupling of 1,1-Dibromo-1-Alkenes with Nitrogen Nucleophiles. Preparation of 4-Methyl-N-(2-Phenylethynyl)-N-(Phenylmethyl)Benzenesulfonamide 231Alexis Coste, François Couty and Gwilherm EvanoDirect Fluorination of the Carbonyl Group of Benzophenones Using Deoxo-Fluor®: Preparation of BIS(4-Fluorophenyl) Difluoromethane 245Ying Chang, Hyelee Lee, Chulsung BaePreparation and [2+2] Cycloaddition of 1-Triisopropylsiloxy-1-Hexyne with Methyl Crotonate: 3-Butyl-4-Methyl-2-Triisopropylsiloxy-Cyclobut-2-Enecarboxylic Acid Methyl Ester 253Valeriy Shubinets, Michael P. Schramm, and Sergey A. KozminPd(0)-Catalyzed Asymmetric Allylic and Homoallylic Diamination of 4-Phenyl-1-Butene with DI-Tert-Butyldiaziridinone 263Baoguo Zhao, Haifeng Du, Renzhong Fu, and Yian ShiSynthesis of Enamides from Ketones: Preparation of N-(3,4-Dihydronaphthalene-1-YL)Acetamide 275Hang Zhao, Charles P. Vandenbossche, Stefan G. Koenig, Surendra P. Singh, and Roger P. BakaleSafe and Scalable Preparation of Barluenga’s Reagent 288Justin M. Chalker, Amber L. Thompson, and Benjamin G. DavisPalladium-Catalyzed Alkyl-Alkyl Suzuki Cross-Couplings of Primary Alkyl Bromides at Room Temperature: (13-Chlorotridecyloxy)Triethylsilane 299Sha Lou and Gregory C. FuSynthesis of Chiral Pyridine Bis(Oxazoline) Ligands for Nickel-Catalyzed Asymmetric Negishi Cross-Couplings of Secondary allylic Chlorides with Alkylzincs:2,6-BIS[(4R)-4,5-Dihydro-4-(2-Phenylethyl)-2-Oxazolyl]-Pyridine 310Sha Lou and Gregory C. FuNickel-Catalyzed Asymetric Negishi Cross-Couplings of Racemic Secondary Allylic Chlorides with Alkylzincs: (S,E)-Ethyl 6-(1,3-Dioxolan-2-YL)-4-Methylhex-2-Enoate 317Sha Lou and Gregory C. FuNickel-Catalyzed Enantioselective Negishi Cross-Couplings of Racemic Secondary a-Bromo Amides with Alkylzinc Reagents: (s)-N-Benzyl-7-Cyano-2-Ethyl-N-Phenylheptanamide 330Sha Lou and Gregory C. FuOne-Pot Synthesis of 5H-Indazolo-[3,2-b] Benzo[d]-1,3-Oxazine: Two Efficient Preparative Methods 339Danielle M. Solano, Jeffrey D. Butler, Makhluf J. Haddadin and Mark J. KurthPreparation of Chiral and Achiral Triazolium Salts: Carbene Precursors with Demonstrated Synthesis Utility 350Harit U. Vora, Stephen P. Lathrop, Nathan T. Reynolds, Mark S. kerr, Javier Read de Alaniz, and Tomislav RovisSynthesis of A N-Mesityl Substituted Aminoindanol-Derived Triazolium Salt 362Justin R. Struble and Jeffrey W. BodePreparation of O-Allyl-N-(9-Anthracenyl-Methyl)-Cinchonidium Bromide as a Phase Transfer Catalyst 377E. J. Corey and Mark C. Noe

"Organic Syntheses, Volume 87 provides carefully checked and edited experimental protocols that describe important synthetic methods, transformations, reagents, and synthetic building blocks or intermediates with demonstrated uitlity in organic synthesis." (Book Circle, 1 September 2011)