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During the last decade, modern technologies have made a revolutionary change in developmental biology. Those new principles will also be important in the stem cell biology, branched from developmental biology, in order to generate a particular tissue by manipulating stem cells.
Hisato Kondoh (PhD. Professor, Graduate School of Frontier Biosciences, Osaka University) Atsushi Kuroiwa (PhD. Professor, Graduate School Science, Nagoya University)
Part I Making cells unequal in a tissue to form embryos and organs.- Chapter 1 Taxon-specific maternal factors for germline specification.- Chapter 2 Establishment of Anterior-Posterior axis in the mouse embryo.- Chapter 3 Cell competition: the struggle for existence in multicellular communities.- Chapter 4 Building functional internal organs from a naïve endodermal sheet.- Part II Choosing a fate from multiple potencies.- Chapter 5 Determination of stem cell fate in planarian regeneration.- Chapter 6 Regulation of axial stem cells deriving neural and mesodermal tissues during posterior axial elongation.- Chapter 7 Tbx1/Ripply3/retinoic acid signal network that regulate pharyngeal arch development.- Part III Cells in a community of reorganizing tissues.- Chapter 8 Interaction of epithelial cells and basement membrane in the regulation of EMT exemplified in chicken embryo gastrulation.- Chapter 9 Making the Neural Plate to Fold into a Tube.- Chapter 10 Contribution of apoptosis in the cranial neural tube closure indicated by mouse embryo live imaging.- Part IV Heterologous tissue interactions to generate a function.- Chapter 11 Secondary Smad1/5/8-dependent signaling downstream of SHH determines digit identity.- Chapter 12 Deciphering cerebellar neural circuitry involved in higher order functions using zebrafish model.- Chapter 13 Primitive erythroblast cell autonomously regulates the timing of blood circulation onset via a control of adherence to endothelium.- Chapter 14 Limb regeneration: Reconstitution of complex organs using specific tissue interactions.- Part V New players in signaling systems.- Chapter 15 Context-dependent bidirectional modulation of Wnt/β-catenin signaling.- Chapter 16 The role of Tsukushi as an extracellular signaling coordinator.- Chapter 17 Divergent roles of heparan sulfate in regulation of FGF signaling during mammalian embryogenesis.- Chapter 18 Cooperation of signaling for tissue interaction and Hox genes in tissue precursorpatterning.- Part VI Evolutional variations stemming from common principles.- Chapter 19 Molecular and cellular bases of sexual flexibility in vertebrates.- Chapter 20 Differential use of paralogous genes via evolution of cis-regulatory elements for divergent expression specificities.- Chapter 21 Fins and Limbs: emergence of morphological differences.- Chapter 22 The turtle evolution - a conundrum in vertebrate Evo-Devo
