Neurotransmitters and Drugs

Häftad, Engelska, 1991

709 kr

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An understanding of the manner in which therapeutically used drugs modify the nervous system requires knowledge of the functions, distribution and control of neurotransmitters. This well-established textbook provides a concise and systematic introduction to the main neurotransmitter substances in the body, their association with clinical states, and the interaction of therapeutically used drugs within these systems. Each chapter is devoted to a specific neurotransmitter substance, and examines their synthesis, storage, release, receptor interaction and inactivating mechanisms, together with important drugs known to interact selectively with these various mechanisms. The treatment of relevant disorders, such as Parkinson's disease and schizophrenia, as well as side effects are discussed. This third edition has been rewritten to reflect recent advances in the field and to incorporate up-to-date references. In particular new material on the structure and function of receptors and on amino acids has been incorporated.Nevertheless, the book retains its compact and didactic style and, in covering all pharmacological aspects of neurotransmission in both the peripheral and central nervous systems, should continue to provide students of medicine, pharmacology, pharmacy and postgraduate psychiatry with a reference source. This book should be of interest to undergraduate students of the neurosciences, pharmacology and pharmacy and postgraduate workers in psychiatry.

Produktinformation

Utgivningsdatum1991-06-30
Mått155 x 235 x 13 mm
Vikt341 g
FormatHäftad
SpråkEngelska
SerieCroom Helm Biology in Medicine Series
Antal sidor204
Upplaga3
FörlagChapman and Hall
ISBN9780412361104

Tillhör följande kategorier

Anatomi inom Medicin
Biovetenskap inom Naturvetenskap och teknik
Farmakologi inom Medicin

1 Neurotransmission: Sites at which drugs modify neurotransmission.- 1.1 The neurone.- 1.2 Axonal transport.- 1.3 Neuronal cell membranes.- 1.4 Precursors.- 1.5 Synthesis.- 1.6 Storage.- 1.7 Organelles and enzymes.- 1.8 Release.- 1.9 Receptors.- 1.10 Inactivation.- 1.11 Neurotransmitters or neuromodulators.- 1.12 Neurotransmitters in the nervous system.- 1.13 Neurotransmitters and drugs.- Further reading.- 2 Acetylcholine.- 2.1 Synthesis.- 2.2 Storage.- 2.3 Release.- 2.4 Cholinergic receptors.- 2.5 Inactivation of acetylcholine.- 2.6 Therapeutic applications and consequences of drugs acting at cholinergic synapses.- Further reading.- 3 Noradrenaline.- 3.1 Synthesis.- 3.2 Storage.- 3.3 Release.- 3.4 Adrenoreceptors.- 3.5 Inactivation of noradrenaline.- 3.6 Therapeutic applications and consequences of drugs acting at noradrenergic synapses.- Further reading.- 4 Dopamine.- 4.1 Synthesis.- 4.2 Storage.- 4.3 Release.- 4.4 Dopamine systems.- 4.5 Inactivation of dopamine.- 4.6 Therapeutic applications and consequences of drugs acting at dopaminergic synapses.- Further reading.- 5 5-Hydroxytryptamine.- 5.1 Synthesis.- 5.2 Storage.- 5.3 Release.- 5.4 5-HT receptors.- 5.5 Inactivation of 5-HT.- 5.6 Therapeutic applications and consequences of drugs acting at 5-HT synapses.- Further reading.- 6 Histamine.- 6.1 Synthesis.- 6.2 Storage.- 6.3 Release.- 6.4 Histamine receptors.- 6.5 Inactivation of histamine.- 6.6 Therapeutic applications and consequences of drug action on histamine systems.- Further reading.- 7 Inhibitory amino acids: GABA, glycine and taurine.- 7.1 Amino acids as neurotransmitters.- 7.2 ?-aminobutyric acid.- 7.3 Glycine.- 7.4 Taurine.- Further reading.- 8 Excitory amino acids: L-glutamic acid and L-aspartic acid.- 8.1 Synthesis.- 8.2 Storage.- 8.3 Release.- 8.4Excitatory amino acid receptors in the CNS.- 8.5 Inactivation of released excitory amino acids.- 8.6 Functional roles of cerebral excitory amino acid neurotransmitters.- Further reading.- 9 Peptides and neuronal function.- 9.1 Peptides as neurotransmitters and hormones.- 9.2 Synthesis, storage, transport, release and inactivation of neuropeptides.- 9.3 Co-existence and co-transmission of peptides with classical neurotransmitters.- 9.4 Opioid peptides.- 9.5 Substance P (the tachykinins).- 9.6 Cholecystokinin (CCK).- 9.7 Vasoactive intestinal polypeptide.- 9.8 Neurotensin.- 9.9 Somatostatin.- 9.10 Bombesin.- Further reading.

From reviews of previous editions:; The structural organisation of the book is excellent. Trends in Neurosciences; The authors have produced a well thought out book, and as an adjunct to more detailed texts, I would recommend this book to second year pharmacology, and medical students. Biochemical Society Transactions; During its brief existence, Neurotransmitters and Drugs has become a standard undergraduate text in pharmacology and is strongly to be recommended for the relevance of its material and clarity of its presentation. Journal of Clinical and Hospital Pharmacy; A good introduction to the pharmacology of neurotransmission, a subject which is yearly increasing in importance. The prose is economic, the style didactic and the result highly effective. British Journal of Psychiatry