Natural Products

As a boy, Dieter Sicker, born in 1954 in Chemnitz, was intrigued by the phenomena of material transformations in the kitchen. However, later, he decided to become a chemist rather than a cook. He is convinced that the manifold knowledge gained in the isolation of natural products is helpful for any organic chemist. Working as a lecturer and a practical supervisor at the Institute of Organic Chemistry at the University of Leipzig, he was awarded the title apl. professor in 1997. He is fond of presenting experimental shows in which the beauty of chemistry is both shown and explained to the public.Klaus-Peter Zeller, born in 1944 in Baden-Baden, worked several years as technician before he could realise his dream to study chemistry. In 1972 he received his doctoral degree from the University of Tübingen. After postdoctoral work at the Heriot-Watt University Edinburgh he returned to Tübingen where he became Professor in 1983. His research and teaching interests focus on reaction mechanisms, photochemistry, mass spectrometry, and more recently science history.In 1968 Hans-Ullrich Siehl started chemistry studies at the University of Tübingen during, the peak years of student movement and protest. Thestructural formula of Astaxanthin was the required answer to the 1973 organic chemistry diploma question, why the color of the lobster change to red on cooking. After his PhD thesis on vinyl cations with Prof. M. Hanack at the University of Saarbrücken he enjoyed eating lobster at weekends in Maine during his postdoctoral work on Isotope eff ects with Prof. M. Saunders at Yale University, Connecticut, 1979. After his Habilitation on NMR spectroscopy of reactive carbocations in Tübingen in 1987 he enjoyed Japanese dishes during a one-year JSPS guest professorship at Kyushu University, Japan. At Ulm University since 1995 his main interests in experimental physical organic chemistry and NMR spectroscopy were successively expanded and complemented by quantum chemical methods such as computational NMR spectroscopy.Stefan Berger was intrigued by NMR after having won a bottle of beer during an introductory course in organic NMR led by Prof. H. Suhr at the University of Tübingen in 1968. After completing a PhD thesis with Prof. Anton Rieker, in 1973 he joined Prof. J. D. Roberts at Caltech for postdoctoral work, where he also met Prof. D.M. Grant and Prof. D. Seebach, who were then guest professors in Pasadena. This period was decisive to try a Habilitation in NMR spectroscopy, which was achieved at the University Marburg. At the University Leipzig his aim is to combine methodological development of NMR and its application to bioorganic problems.

• Preface 3Chapter 1. Alkaloids 91.1 Pseudopelletierine From the root-bark of the pomegranate tree 91.2 Colchicine From the seeds of the autumn crocus 291.3 Capsaicin From Kenyan "African Bird’s Eye Chilies" 49Chapter 2. Coloured Compounds 692.1 Thymoquinone From the oil of the seeds of black caraway 692.2 Berberine Chloride From the bark of the common barberry 892.3 Carminic acid From dried cochineal 1092.4 Safflomin A From flowers of the safflower 1292.5 Chlorophyll a From deep frozen spinach leaves 151Chapter 3. Carbohydrates and Glycosides 1753.1 Raffinose From the seeds of blue lupins 1753.2 Fraxin From the shredded bark of the ash tree 1953.3 Stevioside From the dried leaves of Stevia rebaudiana 215Chapter 4. Terpenoids 2354.1 Linalool From Brazilian rosewood oil 2354.2 Camphor From camphor tree oil 2554.3 Cantharidin From Spanish fly Lytta vesicatoria 2754.4 Artemisinin From the dried leaves of the annual mugwort 2914.5 Diosgenin From an extract of the roots of Mexican yams 3114.6 Friedelin From cork from the bark of the cork-oak 3314.7 Boswellic acid From frankincense, the resin of the Arabian olibanum tree 353Chapter 5. Aromatic Compounds 3755.1 Sinensetin From cold-pressed orange oil 3755.2 Rosmarinic acid From the dried leaves of lemon balm 391Chapter 6. Quantum Chemical Calculation 411Appendix 417Spectroscopic Experiments 417External Photographic Credits 418Text Credits 419Chemical Substance Index 421General Subject Index 424Name Index 432

"This is an outstanding book that should be on the shelves of all chemists. I can best summarise it by reproducing part of Wiley’s description on the rear cover “Educating and entertaining this full-colour textbook turns the learning process into a real pleasure, not only for students in natural products chemistry but also experienced professionals”." Edlard R. Adlard, Chromatographia (2019) 82:1425