Molecular Mechanisms of Dementia

Inbunden, Engelska, 1996

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Wilma Wasco and Rudolph Tanzi bring together the best and latest thinking by leading scientists on the etiologic and pathogenic events responsible for the onset of Alzheimer's disease and related dementias. In presenting the various mechanisms and multifaceted approaches currently being employed, the distinguished contributors review such critical factors as apoptosis, energy metabolism, excitotoxicity and calcium-mediated cell death, free radicals, electrophysiological abnormalities, environmental toxins, degeneration of neural networks, and modification of the cytoskeleton. They also examine mechanisms by which ischemia and hypoxia result in dementia. The book provides critical insights into the necessary direction of future investigations of dementia.

Produktinformation

Utgivningsdatum1996-11-01
Mått178 x 254 x undefined mm
FormatInbunden
SpråkEngelska
SerieContemporary Neuroscience
Antal sidor312
FörlagHumana Press Inc.
ISBN9780896033719

Tillhör följande kategorier

Psykiatri inom Medicin
Biologi inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik
Neurologi och klinisk neurofysiologi inom Medicin

1 Etiological Clues from Gene Defects Causing Early Onset Familial Alzheimer’s Disease.- 2 Potential Biological Mechanisms of ApoE in Alzheimer’s Disease.- 3 Understanding the Biology and Molecular Pathogensis of Alzheimer’s Disease in Transgenic Mice Expressing Amyloid Precursor Proteins.- 4 Mechanism for ?-Amyloid Overproduction in Alzheimer Disease: Possible Antisense RNA-Mediated Generation of a 5?-Truncated?APP mRNA Encoding 12-kDa C-Terminal Fragment of ?APP, the Immediate Precursor of A?.- 5 Apoptosis and Alzheimer’s Disease.- 6 The ?-Amyloid Model of Alzheimer’s Disease: Conformation Change, Receptor Cross-Linking, and the Initiation of Apoptosis.- 7 Energy/Glucose Metabolism in Neurodegenerative Diseases.- 8 Calcium Homeostasis and Free Radical Metabolism as Convergence Points in the Pathophysiology of Dementia.- 9 ?-Amyloid-Derived Free Radical Oxidation: A Fundamental Process in Alzheimer’s Disease.- 10 Inflammatory Pathways: Implications in Alzheimer’s Disease.- 11 Inflammatory Mediators in Alzheimer’s Disease.- 12 ? Protein and the Neurofibrillary Pathology of Alzheimer’s Disease.- 13 Anatomy of Pathological Alterations in Alzheimer’s Disease.- 14 Cerebral Zinc Metabolism in Alzheimer’s Disease.- 15 Potassium Channels and Calcium Release: Pat ho physiological and Diagnostic Implications for Alzheimer’s Disease.- 16 Pick Disease.- 17 Ischemia.- 18 Prion Diseases and Dementia.

In conclusion, the first chapters of this book provide a lot of very recent information related to the production and the toxicity of the amyloid peptide as well as to the possible role of new genes involved in Alzheimer's disease. It represents a very interesting review for scientists studying the cellular and molecular mechanisms involved in the neurodegeneration of Alzheimer's disease.-ACTA Neurologica Belgica "The text is logically organized, which helps in making a transition from one subject to the other. The topics are well selected; classical, and new, often controversial, research is covered. Each chapter is succinct and ends with an informative summary...this expertly written overview also provides directions for future studies...a valuable reference and source of inspiration. It is highly recommended to all interested in the molecular basis of neurodegenerative diseases."-Cell Biology International