Mitochondrial Inhibitors and Neurodegenerative Disorders

Häftad, Engelska, 2012

AvPaul R. Sanberg,Hitoo Nishino,Cesario V. Borlongan,Paul R. Sanberg

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Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function.

Produktinformation

Utgivningsdatum2012-07-27
Mått152 x 229 x 19 mm
Vikt482 g
FormatHäftad
SpråkEngelska
SerieContemporary Neuroscience
Antal sidor314
FörlagHumana Press Inc.
ISBN9781468498219

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I. Mitochondrial Toxins: Symptomatology, Origin, and Chemistry.- 1 • Clinical Manifestations and Mechanisms of Action of Environmental Mitochondrial Toxins.- 2 • History of 3-Nitropropionic Acid: Occurrence and Role in Human and Animal Disease.- 3 • The Neurochemistry of 3-Nitropropionic Acid.- II. Mitochondrial Dysfunctions: Models of Neurodegeneration and Mechanisms of Action.- 4 • In Vitro Studies of 3-Nitropropionic Acid.- 5 • Cognitive and Motor Deficits Produced by Acute and Chronic Administration of 3-Nitropropionic Acid in Rats.- 6 • Comparative Study on 3-Nitropropionic Acid Neurotoxicity.- 7 • Mechanisms of 3-Nitropropionic Acid Neurotoxicity.- 8 • Gender-Related Difference of the Effect of 3-Nitropropionic Acid on Striatal Artery.- 9 • Variable Susceptibility to Neurotoxicity of Systemic 3-Nitropropionic Acid.- 10 • The 3-Nitropropionic Acid Model of Huntington’s Disease: Do Alterations in the Expression of Metabolic mRNAs Predict the Development of Striatal Pathology?.- 11 • Mechanisms of Action of 3-Nitropropionic Acid: Dopamine Overflow and Vulnerability of the Lateral Striatal Artery.- 12 • Mitochondrial Inhibition and Neuronal Death in Huntington’s Disease.- 13 • Effects of Brain Mitochondrial Metabolism, Aging, and Caloric Restriction on Membrance Lipids and Proteins: An Electron Paramagnetic Resonance Investigation.- 14 • Malonate: Profile and Mechanisms of Striatal Toxicity.- 15 • Malonic Acid and the Chronic Administration Model of Excitotoxicity.- 16 • Sodium Azide-Induced Neurotoxicity.- III. Treatment Interventions for Mitochondrial-Induced Neurotoxicity.- 17 • Neuroprotective Strategies Against Cellular Hypoxia.- 18 • Neuroprotective Effect of Perinatal Hypoxia Against 3-Nitropropionic Acid Neurotoxicity.-19 • Neural Transplantation and Huntington’s Disease: What Can We Learn from the 3-Nitropropionic Acid Model?.- 20 • Neuroprotective Strategies in Parkinson’s Disease and Huntington’s Chorea: MPTP- and 3-NPA-Induced Neurodegeneration as Models.