Microfluidics and Nanofluidics

Clement Kleinstreuer, PhD, is a professor of mechanical and biomedical engineering at North Carolina State University. His current research pertains to computational fluid-particle dynamics with applications of micro/nanofluidics to medical device development.

• Preface xvPart A: A REVIEW OF ESSENTIALS IN MACROFLUIDICS 1CHAPTER 1 Theory 31.1 Introduction and Overview 31.2 Definitions and Concepts 81.3 Conservation Laws 231.4 Homework Assignments 74CHAPTER 2 Applications 792.1 Internal Fluid Flow 792.2 Porous Medium Flow 1082.3 Mixture Flows 1182.4 Heat Transfer 1512.5 Convection-Diffusion Mass Transfer 1622.6 Homework Assignments 176References (Part A) 186Part B: MICROFLUIDICS 189CHAPTER 3 Microchannel Flow Theory 1913.1 Introduction 1913.2 Basic Concepts and Limitations 1953.3 Homework Assignments 251CHAPTER 4 Applications in Microfluidics 2554.1 Introduction 2554.2 Micropumps and Microchannel Flow 2564.3 Micromixing 2804.4 Laboratory-on-a-Chip Devices 2844.5 Homework Assignments and Course Projects 288References (Part B) 290Part C: NANOFLUIDICS 293CHAPTER 5 Fluid Flow and Nanofluid Flow in Nanoconduits 2955.1 Introduction 2955.2 Liquid Flow in Nanoconduits 3035.3 Rarefied Gas Flow in Nanochannels 3285.4 Homework Assignments and Course Projects 335CHAPTER 6 Applications in Nanofluidics 3396.1 Introduction 3396.2 Nanoparticle Fabrication 3406.3 Forced Convection Cooling with Nanofluids 3426.4 Nanodrug Delivery 3516.5 Homework Assignments and Course Projects 356References (Part C) 358Part D: COMPUTER SIMULATIONS OF FLUID-PARTICLE MIXTURE FLOWS 361CHAPTER 7 Modeling and Simulation Aspects 3637.1 Introduction 3637.2 Mathematical Modeling 3657.3 Computer Simulation 367CHAPTER 8 Computational Case Studies 3758.1 Introduction 3758.2 Model Validation and Physical Insight 3768.3 Solid Tumor Targeting with Microspheres 3868.4 Homework Assignments and Course Projects 390References (Part D) 393APPENDICES 395APPENDIX A 397A.1 Tensor Calculus 397A.2 Differentiation 403A.3 Integral Transformations 407A.4 Ordinary Differential Equations 411A.5 Transport Equations (Continuity, Momentum, and Heat Transfer) 415APPENDIX B 420B.1 Conversion Factors 420B.2 Properties 423B.3 Drag Coefficient: (A) Smooth Sphere and (B) An Infinite Cylinder as a Function of Reynolds Number 427B.4 Moody Chart 428References (Appendices) 429INDEX 431