Microbial Stress Survival

Dr. Ashutosh Kumar is an active researcher and scientific writer in his field for over 14 years and presently working at Department of Microbiology, Tripura University (A Central University), Suryamaninagar, Agartala, Tripura, India. He received MSc and PhD degree in Biotechnology from University of Hyderabad, India. He did his postdoctoral research at TIFR-National Centre for Biological Sciences Bangalore, Indian Institute of Technology Delhi and Jamia Hamdard, New Delhi, India. He also worked as a Visiting Research Scientist at Robert Koch Institute Berlin, Germany. He has made significant contributions to the study of virulence mechanisms and strategies of survival, adaptation, and persistence of Mycobacterium tuberculosis. He was involved in identification of an enzyme from M. tuberculosis that promote biofilm formation and drugs that enhanced the potency of two current anti-tuberculosis antibiotics. He received many scholarships, awards, and fellowship during his education. He has many publications in international journals and books.

• 1. Two-component systems of pathogens (Mycobacterium tuberculosis/ Streptococcus pneumoniae/ Salmonella enterica / Helicobacter Pylori etc.) in stress sensing and adaptations2. Role of lipoproteins in the pathogenesis of Mycobacterium tuberculosis3. PhoPR two-component system mycobacterial virulence4. SenX3–regX3 two-component regulatory System proteins in the pathogenesis of Mycobacterium tuberculosis5. Mycobacterial membrane vesicles in host-pathogen interactions and pathogenesis6. Different growth regulation strategies of microbes for survival and reactivation during stress7. Microbial secretion system and quorum sensing8. Bacteria and biofilms as natural inhabitants of our body and biofilms in chronic infections9. Molecular level drug tolerance and resistant strategies in a diverse group of pathogenic microbes and the uses of different antimicrobial agents10. Adaptation to various antimicrobial agent (resistance) stress in diverse pathogenic microbes11. Adaptation mechanisms in the initiation factors involved in the translation process of thermophilic bacteria12. Structural adaptations in the of valine--tRNA ligases of different halophiles13. Molecular evolution steered adaptations in the phosphoglycerate and pyruvate kinase of piezophilic bacteria14. Recent advances in the survival and adaptation strategies of microbes in extreme radiation15. Cold dwelling microorganisms – A theory on psychrophilic adaptation16. Structural adaptations in the CRISPR-Cas of different thermophiles