'At a time when "evidence" has become central to debates about healthcare and rationing, this important book brings together valuable studies that show how contingent and complex the construction of evidence in clinical trials really is.' Carl May, Newcastle University, UK 'Relying upon detailed multidisciplinary investigations of clinical trials, this highly original book provides illuminating insights into the ongoing (silent) transformation of our societies into evidence-based societies.' Michel Callon, Mines Paris Tech, France '... an excellent book that should and will find readership not only as a seminal collection on clinical trials but also as a locus for broader debate in the sociology of health and illness, political sociology, and science and technology studies.' Network, the Magazine of the British Sociological Association 'The real strength of this book is the brilliant use of real life examples to illustrate its key points... examples demonstrate the social reality in which clinical trials are carried out and the challenges that this generates. The large number of contributing authors means that each issue is tackled from a slightly different perspective resulting in a rich set of ideas and philosophies. Most importantly, the sociological research described in this book provides not only a means by which to criticize the limitations of RCTs, as has been done countless times before, but also as a way to better understand the evidence that they generate and to provide solutions to some of these limitations. Because of the breadth of information provided and the importance of the subject matter, this book will be of interest to anyone involved in the generation or application of medical evidence.' Health Sociology Review