Lange Clinical Neurology

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• Chapter 1. NeurologicHistory & ExaminationNeurologic examination ofsphincter functionChapter 2. InvestigativeStudiesNeuromuscular imaging studiesUpdate on ultrasonography forneuromuscular diagnosisChapter 3. ComaIntroductionRole of prefrontal cortex in consciousnessCauses of comaSpontaneous intracranialhypotension as a cause of comaPersistent vegetative stateNew imaging insights intopersistent vegetative & minimally conscious statesTreatment of traumatic vegetative &minimally conscious states with amantadineChapter 4. ConfusionalStatesDrugsSerotonin syndromeElectrolyte disordersAntidepressant-inducedhyponatremiaEndocrine & metabolic disordersMechanisms of impairedhypoglycemia sensing in treated diabetesNutritional disordersFurosemide-induced thiaminedeficiencyOrgan system failureICU deliriumPostoperative cognitivedysfunctionMeningitis, encephalitis & sepsisMechanism of N. meningitidis vascular spreadDysregulated host inflammatoryresponse in tuberculous meningitisCSF findings in HIV-infectedpatients with tuberculous meningitisTick-borne encephalitis & (re-emergent)yellow feverNipah virus encephalitisUpdated diagnostic testing forviral encephalitisNew recommendation on empiricaltreatment of toxoplasmosis in AIDSFexinidazole for treatment of Africantrypanosomiasis Mechanism of meningeal invasion inleukemiaChapter 5. Dementia& Amnestic DisordersIntroductionSomatic neuronal mutations in aging and neurodegenerationDifferential diagnosisBiomarker-based diagnostic algorithms for dementia syndromesNeurodegenerativeproteinopathiesTau folding in Alzheimer vs. PickdiseaseTau-disrupted nucleocytoplasmictransport in Alzheimer disease pathogenesisContrasting mechanisms ofaggregate toxicity in neurodegenerationHerpes simplex virus infection andAlzheimer diseaseInflammation in Alzheimer diseasepathogenesisMeningeal lymphatics (glymphatics)in Alzheimer disease pathogenesisBlood pressure and risk of AlzheimerdiseaseRelation between epilepsy anddementiaExercise training in dementiaSex differences in AlzheimerdiseaseSpatial navigation deficits asearly signs of Alzheimer diseaseSubjective cognitive decline in relationto Alzheimer diseaseUpdate on biomarkers for AlzheimerdiseaseConcomitant neurodegenerativeproteinopathiesUpdate on clinical trials oftreatments for Alzheimer disease (eg, solanezumab, verubecestat)Clinical and pathologicalcorrelates of primary progressive aphasia variantsNew consensus guidelines fordiagnosis & treatment of dementia with Lewy bodiesSkin prions in Creutzfeldt-Jakobdisease infectivity and diagnosisOther cerebral disordersShunting response to gait vs. dementia in normal pressurehydrocephalusNormal pressure hydrocephalus vs.neurodegenerative ventriculomegalyMild traumatic brain injury & dementiaSystemic disordersSubclinical hyperthyroidism &dementiaPseudodementiaFeatures of memory impairment in depressionAmnestic syndromesUpdate on antibody-mediatedencephalitis antigens & treatmentChapter 6. Headache& Facial PainMigraineTriptans, SSRIs & serotoninsyndromeCGRP receptor-blocking monoclonalantibodies (eg, erenumab, fremanezumab)Prochlorperazine plusdiphenhydramine vs. hydromorphone for IV migraine therapyVagus nerve