Issues in Clinical Epileptology: A View from the Bench

Inbunden, Engelska, 2014

Av Helen E. Scharfman, Paul S. Buckmaster, Ph.D. Buckmaster, Paul S., DVM

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For all of the individuals who have been trained or worked with Philip Schwartzkroin in the past and/or have appreciated his contributions to the epilepsy field, this volume is an excellent way to celebrate his achievements and look to the ways they have moved the field forward and continue to stimulate its growth.

Produktinformation

Utgivningsdatum2014-07-11
Mått178 x 254 x 24 mm
Vikt860 g
FormatInbunden
SpråkEngelska
SerieAdvances in Experimental Medicine and Biology
Antal sidor339
FörlagSpringer
ISBN9789401789134

Tillhör följande kategorier

Epidemiologi och medicinsk statistik inom Medicin
Biovetenskap inom Naturvetenskap och teknik
Neurokirurgi inom Medicin
Neurologi och klinisk neurofysiologi inom Medicin

Preface.- Foreword.- Part I Seizures, epileptiform activities and regional localization.- How can we identify ictal and interictal abnormal activity?- How can we translate “epileptiform” activity in vitro into something that is clinically relevant?- What is the importance of abnormal “background” activity in seizure generation?- What is a seizure focus?- What is a seizure network? Very fast oscillations at the interface between normal and epileptic brain.- What is a seizure network? Long-range network consequences of focal seizures.- Is there any such thing as “generalized” epilepsy?- Part II Synaptic plasticity.- Are there really “epileptogenic” mechanisms or only corruptions of “normal” plasticity?- When and how do seizures kill neurons - and is cell death relevant to epileptogenesis?- How is homeostatic plasticity important in epilepsy?- Is plasticity of GABA ergic mechanisms relevant to epileptogenesis?- Do structural changes in GABA neurons give rise to the epileptic state?- Does mossy fiber sprouting give rise to the epileptic state?- Does brain inflammation mediate pathological outcomes in epilepsy?- Are changes in synaptic function that underlie hyperexcitability responsible for seizure activity?- Does epilepsy cause a reversion to immature function?- Are alterations in transmitter receptor and ion channel expression responsible for the epilepsies?- Part III Models and methods.- How do we assess the clinical relevance of models of mesial temporal lobe epilepsy?- How do we make models that are useful in understanding partial epilepsies?- What non-neuronal mechanisms should be studied to understand epileptic seizures?- What epilepsy comorbidities are important to model in the laboratory? Clinical perspectives.- Understanding epilepsy comorbidities: how can animal models help?- What new modeling approaches will help us identify promising drug treatments?- What are the arguments for and againstrational therapy for epilepsy?- How can advances in epilepsy genetics lead to better treatments and cures?- How might novel technologies such as optogenetics lead to better treatments in epilepsy?.