HNE and Further Lipid Peroxidation Products

This book focuses on products of lipid peroxidation used as biomarkers of oxidative stress. Oxygen free radicals are implicated in many diseases and 'normal' processes, such as ischemiareperfusion injury, cataracts, age-related macula degeneration, cancer, inflammation, aging, diabetes and neurodegenerative diseases. Assessment of oxidative stress by measurement of lipid peroxidation (LPO) products is of biological and clinical importance when considering the multiple functions of lipids such as steroid hormones, retinoic acids and prostaflandins. Beyond, LPO products such as 4-hydroxunonenal (HNE), acrolein, F2-isoprostanes and oxysterols exert signal functions that significantly influence gene expression and protein synthesis, and such regulatory phenomena may affect the organism more dramatically. In short, LPO is biologically and medically important.This book covers the entire field of HNE research, including subjects as Cell Cycle and Proteolysis, LPO Products, Antioxidants and Detoxification, Neurodegeneration and Aging, Lipid Peroxidation, HNE and Gene Regulation, Detection of Oxidants and LPO Products, LDL and Atherosclerosis, Clinical Applications and HNE, Mitochondria and Metabolic Regulation. This publication is dedicated to Professor Alex Sevanian (1946-2005).