Hematopathology

Dr. Elaine Jaffe is regarded by her peers as one of the most pre-eminent hematopathologists of her generation. She is most widely known for her work regarding the pathophysiology and prognosis of malignant lymphomas, as well as her unparalleled work to understand how they respond to treatment. Dr. Jaffe led the effort to develop the World Health Organization classification of tumors of the hematopoietic and lymphoid tissues published in 2001, a classification that rapidly became the international standard. Dr. Daniel Arber is an internationally recognized expert in the diagnosis and classification of hematopoietic tumors, including malignant lymphoma, acute and chronic leukemia, myeloproliferative disorders, myelodysplastic syndrome and tumors of the spleen. the clinical director of the Biomedical Diagnostic Centre of Hospital Clinic and a full Professor of Anatomical Pathology at the University of Barcelona, where he also teaches in the Department of Anatomical Pathology, Pharmacy and Microbiology. He is the Spanish coordinator of the International Cancer Genome Consortium. Professor Dr. Leticia Quintanilla de Fend, head of the Core Facility and Senior Physician at the Institute of Pathology has extensive experience in the interpretation of mouse models. From 2000 until 2008 she was a director of the mouse pathology at the Institute of Pathology of the Helmholtz Center Munich and the Pathology Screen of the German Mouse Clinic (GMC) and established various special procedures for the analysis of mouse models. Professor Quintanilla de Fend is involved in the establishment of standards in the pathology of mouse models within EU networks. Dr. Attilio Orazi is an internationally renowned academic hematopathologist whose diagnostic expertise spans all areas of hematopathology. However, he is best known for his expertise and scholarly accomplishments as a bone marrow pathologist. He is a member of the Scientific Committee of the European Bone Marrow Working Group, has directed courses concerning the assessment of bone marrow disorders and splenic pathology at the United States and Canadian Academy of Pathology and was the co-organizer of the 2007 Workshop of the Society of Hematopathology.

• PART I Technical Aspects1. Processing of the Lymph Node Biopsy Specimen2. Fine-Needle Aspiration of Lymph Nodes3. Immunohistochemistry for the Hematopathology Laboratory4. Flow Cytometry5. Molecular Pathology of Hematologic Neoplasms6. Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose ThemPART II Normal and Reactive Conditions of Hematopoietic Tissues7. Normal Lymphoid Organs and Tissues8. Reactive Lymphadenopathies9. The Normal Bone Marrow10. Evaluation of Anemia, Leukopenia, and Thrombocytopenia11. Bone Marrow Findings in Inflammatory, Infectious, and Metabolic DisordersPART III Lymphoid Neoplasms12. Principles of Classification of Lymphoid NeoplasmsSECTION 1 . MATURE B-CELL NEOPLASMS13. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Monoclonal B-Cell Lymphocytosis, and B-Cell Prolymphocytic Leukemia14. Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia15. Hairy Cell Leukemia16. Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen17. Follicular Lymphoma18. Extranodal Marginal Zone Lymphoma: MALT Lymphoma19. Primary Cutaneous B-Cell Lymphomas20. Nodal Marginal Zone Lymphoma21. Mantle Cell Lymphoma22. Aggressive B-Cell Lymphomas Including Diffuse Large B-Cell Lymphoma, Not Otherwise Specified and Other Nodal and Extranodal Large B-Cell Lymphomas23. Burkitt Lymphoma, High-Grade B-Cell Lymphoma Not Otherwise Specified, High-Grade B-Cell Lymphoma With MYC and BCL2/BCL6 Rearrangements, Large B-Cell Lymphoma With 11q Aberration, and Provisional Entity High-Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements24. Plasmablastic Neoplasms Other Than Plasma Cell Myeloma25. Plasma Cell Neoplasms26. Nodular Lymphocyte-Predominant B-Cell Lymphoma27. Classic Hodgkin Lymphoma28. Virally Associated B-Cell Lymphoproliferative DiseaseSECTION 2 . MATURE T-CELL AND NK-CELL NEOPLASMS29. Epstein-Barr Virus-Associated T-Cell and Natural Killer-Cell Lymphoproliferative Disorders30. T-Cell and NK-Cell Large Granular Lymphocyte Proliferations31. T-Cell Prolymphocytic Leukemia32. Adult T-Cell Leukemia/Lymphoma33. Hepatosplenic T-Cell Lymphoma34. Peripheral T-Cell Lymphoma, Not Otherwise Specified35. Follicular Helper T-Cell Lymphoma36. Anaplastic Large Cell Lymphoma, ALK Positive and ALK Negative37. Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas38. Mycosis Fungoides and Sézary Syndrome39. Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders40. Primary Cutaneous T-Cell Lymphomas: Rare SubtypesSECTION 3 . PRECURSOR B- AND T-CELL NEOPLASMS41. Precursor B-Cell and T-Cell Neoplasms42. Acute Leukemias of Ambiguous LineagePART IV Myeloid, Histiocytic, and Related Proliferations43. Principles of Classification of Myeloid Neoplasms44. The Myelodysplastic Syndromes45. Myeloid and Hematologic Neoplasms With Germline Predisposition46. Acute Myeloid Leukemia47. Myeloproliferative Neoplasms48. Myelodysplastic/Myeloproliferative Neoplasms and Premalignant Conditions49. Mastocytosis50. Eosinophilia, Chronic Eosinophilic Leukemia, Not Otherwise Specified, and Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions51. Blastic Plasmacytoid Dendritic Cell Neoplasm52. Histiocytic and Dendritic Cell Proliferations-Systemic and NeoplasticPART V Immunodeficiency Disorders53. The Pathology of Primary Immunodeficiencies54. Iatrogenic Immunodeficiency-Associated Lymphoproliferative DisordersPART VI Site-Specific Issues in the Diagnosis of Lymphoma and Leukemia55. Bone Marrow Evaluation for Lymphoma56. Evaluation of the Bone Marrow After Therapy57. Non-hematopoietic Neoplasms and Other Lesions of the Bone Marrow and Lymph Nodes58. Spleen: Normal Architecture and Neoplastic and Non-neoplastic Lesions59. Diagnosis of Lymphoma in Extranodal Sites Other Than SkinAPPENDIX A: THE INTERNATIONAL CONSENSUS CLASSIFICATION OF MYELOID, LYMPHOID, AND HISTIOCYTIC NEOPLASMS

"This book remains one of the must-haves for anyone signing out hematopathology specimens. It is comprehensive and appropriate for all levels of expertise, and it is a great learning resource for hematopathology fellows." ©Doody’s Review Service, 2025, Anamarija Perry, MD (University of Michigan Medical School), Doody’s Score: 99 - 5 Stars!