Gregory L. Verdine, Department of Stem Cell and Regenerative Biology, Chemistry and Chemical Biology and Molecular and Cellualr Biology, Harvard University Susan K. Dutcher, Department of Genetics, Washington University School of MedicineTom A. Rapoport, Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical SchoolMichael E. Greenberg, Children's Hospital Boston, Program in Neurobiology and Harvard Medical School, Department of NeurobiologyKathryn V. Anderon, Developmental Biology Program, Sloan-Kettering InstituteLeonard I. Zon, Grousbeck Professor of Pediatrics, Children's Hospital Boston, Howard Hughes Medical InstituteMichael Karin, Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, Cancer Center, School of Medicine, University of California at San Diego