Handbook of Venous Thromboembolism

JECKO THACHIL, MBBS, MD, MRCP, FRCPath is a consultant haematologist at Department of Haematology, Manchester Royal Infirmary in Manchester, UK. He has a special clinical interest in blood coagulation disorders and the prevention and treatment of venous thrombosis. He is the editor of the Wiley-Blackwell publication Haematology in Critical Care. CATHERINE BAGOT, BSc, MBBS, MD, MRCP, FRCPath is a consultant haematologist at Department of Haematology, Glasgow Royal Infirmary in Glasgow, UK. He specializes in haemostasis and thrombosis at Glasgow Royal Infirmary and who is mainly interested in the role of thrombin generation in thrombosis risk stratification.

• List of Contributors viiiForeword xiSection I Clinical Overview 11 Risk Factors for Venous Thromboembolism 3Peter E. Rose2 Management of Venous Thrombosis in the Lower Limbs 13Dan Horner3 Clinical Presentation of Acute Pulmonary Embolism 21C.E.A. Dronkers, M.V. Huisman and F.A. KlokSection II Diagnosis 274 Clinical Prediction Scores 29Kerstin de Wit and Lana A. Castellucci5 Laboratory Aspects in Diagnosis and Management of Venous Thromboembolism 35Giuseppe Lippi and Emmanuel J. Favaloro6 Thrombophilia Testing 49Massimo Franchini7 Radiological Diagnosis of Pulmonary Embolism 55Joachim E. Wildberger and Marco Das8 The Antiphospholipid Syndrome 60Karen BreenSection III Treatment 679 Inpatient or Outpatient Anticoagulation 69Lauren Floyd and Jecko Thachil10 An Anticoagulant Service in Practice 73Kathy Macintosh, Dawn Kyle and Linda Smith11 Point of Care Testing 86Dianne Patricia Kitchen12 Direct Oral Anticoagulants in the Prevention and Management of Venous Thromboembolism 94Yen]Lin Chee and Henry G. Watson13 The Role of Thrombolysis in the Management of Venous Thromboembolism 102Carlos J. Guevara and Suresh Vedantham14 Inferior Vena Cava Filters in the Management of Venous Thromboembolism 114Anita Rajasekhar and Molly W. MandernachSection IV Special Situations 12915 VTE in Pregnancy 131Catherine Nelson Piercy16 Paediatric Venous Thromboembolism 145Paul Monagle and Rebecca Barton17 Cancer]associated Thrombosis 153Simon Noble18 Venous Thromboembolism Management in Obese Patients 161Kathryn Lang and Jignesh Patel19 Venous Thromboembolism in Intensive Care 169Gill Parmilan and Jecko Thachil20 Venous Thromboembolism; a Primary Care Perspective 174David FitzmauriceSection V Unusual Site Thrombosis 18121 Cerebral Venous Thrombosis 183Christian Weimar22 Upper Extremity Thrombosis 192Scott M. Stevens and Scott C. Woller23 Management of Intra]abdominal Thrombosis 205Serena M. Passamonti, Francesca Gianniello and Ida Martinelli24 Thrombosis in the Retinal Circulation 216Wenlan Zhang and Paul HahnSection VI Long]term Sequelae of VTE 22925 Post]thrombotic Syndrome 231Andrew Busuttil and Alun H. Davies26 Chronic Thromboembolic Pulmonary Hypertension 240Demosthenes G. Papamatheakis and William R. Auger27 Predicting Recurrent VTE 255R. Campbell TaitSection VII Controversies 26328 Cancer Screening in Unprovoked Venous Thromboembolism 265David Keeling29 Sub]segmental and Incidental PE – to Treat or Not? 269Jecko Thachil30 Management of Distal Vein Thrombosis 273Giuseppe Camporese and Enrico BernardiSection VIII Prevention 28131 A Summary of the Evidence for VTE Prevention, with a Focus on the Controversies 283Catherine Bagot32 VTE Prevention: Real World Practice 293Emma Gee33 VTE Root Cause Analysis – How To Do It 301Alison Moughton, Francesca Jones and Will LesterIndex