Haematology in Critical Care

Dr Jecko Thachil, Honorary Consultant in Haemostasis and Thrombosis, Royal Liverpool Teaching Hospitals, Academic Clinical Lecturer, Infection and Global Health, University of Liverpool, Liverpool, UKDr Thachil co-chairs the Disseminated Intravascular Coagulation Subcommittee of the International Society of Thrombosis and Haemostasis and is the review editor for Physician Information and Educational Resource for American College of Physicians. He has authored over seventy publications in peer reviewed journals and has co-authored the British committee of Standards in Haematology guideline for DIC. Dr Thachil also has research collaborations with intensive care staff in the northwest England and is the organizer of Haematology in Intensive Care educational sessions for the region.Dr Quentin A. Hill, Consultant Haematologist, Leeds Teaching Hospital NHS Trust, Honorary Senior Lecturer, University of Leeds, Leeds, UKDr Hill has been principle investigator for a number of phase II and III clinical trials and has published 6 peer reviewed journal articles (5 as first author). He has also written book chapters for "Problem Solving in Haematology" published in March 2010 (ISBN: 1846920051, Atlas Medical Publishing, Ltd). He provides attending cover for a 40 bedded haematology unit.  He often interacts with intensive care staff and has developed an interest in critical care issues during this time. Dr Hill has published a single author review on survival of critically ill patients with haematological malignancy in 2010 and has submitted a further paper on regional ICU outcomes for publication. Dr Hill has lectured on this subject regionally and nationally.

• List of Contributors, vPreface, ixAcknowledgements, xSection 1 Approach to Abnormal Blood Tests1 Diagnostic Approach to Anaemia in Critical Care, 3Stephen F. Hawkins and Quentin A. Hill2 Leukopenia, 9Stephen F. Hawkins, Jecko Thachil and Quentin A. Hill3 Thrombocytopenia in the Intensive Care Unit, 12Jecko Thachil4 High Blood Counts, 16Quentin A. Hill5 The Abnormal Clotting Profile, 26Jecko Thachil6 Understanding the Blood Film, 31Stephen F. Hawkins and Quentin A. HillSection 2 Approach to Coagulation Problems7 Venous Thromboembolism in Intensive Care, 39Sarah A. Bennett and Roopen Arya8 Reversal and Monitoring of Anticoagulants, 45Joost J. van Veen9 Disseminated Intravascular Coagulation, 52Jecko Thachil10 Heparin-Induced Thrombocytopenia, 58Jerrold H. Levy and Anne M. Winkler11 Thrombotic Microangiopathies, 62Mari Thomas and Marie Scully12 Critical Care of Patients with a Congenital Bleeding Disorder, 69Vanessa MartlewSection 3 Approach to Transfusion Problems13 Blood Components and Their Contents, 77Shubha Allard14 Transfusion Reactions, 86Therese A. Callaghan15 The Management of Non-traumatic Massive Haemorrhage, 93Nicola S. Curry and Simon J. Stanworth16 Plasma Exchange, 100Khaled El-GharianiSection 4 Approach to Red Cell Problems17 Appropriate Haemoglobin in Intensive Care, 107Jonathan Wallis and Stephen Wright18 Sickle Cell Disease and Thalassaemia in the Critical Care Setting, 112Andrew Retter and Jo Howard19 Management of Patients Who Refuse Blood Transfusion, 118Derek R. Norfolk and Fran HartleySection 5 Approach to White Cell Problems20 Infectious Complications in the Immunosuppressed Patient, 125Tim Collyns and Elankumaran Paramasivam21 Haematopoietic Stem Cell Transplantation (HSCT), 135John Snowden and Stephen Webber22 Multiple Myeloma and Hyperviscosity Syndrome, 144Amin Rahemtulla and Joydeep Chakrabartty,23 Palliative Care for the Patient with Haematological Malignancy in Intensive Care, 148Suzanne KiteSection 6 Admission to Intensive Care24 Haematological Malignancy Outside Intensive Care: Current Practice and Outcomes, 159Charlotte Kallmeyer25 Early Care of the Unstable Patient: Preventing Admission to the Intensive Care Unit, 165Andrew Breen26 Decisions to Intensify Treatment: Who Will Benefit from Intensive Care?, 171Quentin A. Hill and Peter A. HampshireSection 7 Point-of-Care Testing27 The Relevance of Thromboelastography in Intensive Care Patients, 179Jon Bailey and Nicola S. CurrySection 8 Haematology Drugs in Critical Care28 Recombinant Activated Coagulation Factor VII (rFVIIa) in Critical Care, 187Leon Cloherty and Richard Wenstone29 The Use of Haemostatic Drugs in Post-operative Bleeding, 192Catharina Hartman and Nigel Webster30 Delivering Chemotherapy on Intensive Care, 196Arvind Arumainathan and Daniel CollinsSection 9 Haematology in Paediatric and Neonatal Intensive Care31 Neonatal Anaemia, 207Michael Richards32 Haemolysis, 213Michael Richards33 Approach to Thrombocytopenia, 219Amrana Qureshi34 Blood Component Therapy in Children and Neonates, 224Anne Kelly, Simon J. Stanworth and Helen V. NewSection 10 Haematological Emergencies35 Haematological Emergencies, 235Quentin A. Hill and Amin RahemtullaAppendix A: Adult, Paediatric and Neonatal Haematology Reference Intervals, 243Quentin A. HillIndex, 249