Handbook of Dynein

Inbunden, Engelska, 2012

2 749 kr

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This book draws together recent data on both cytoplasmic and flagellar dyneins and the proteins they interact with, to give readers a clear picture of what is currently known about the structure and mechanics of these remarkable macro-molecular machines. Each chapter is written by active researchers, with a focus on currently used biophysical, biochemical, and cell biological methods. This is a useful handbook for frontline researchers as well as a textbook for advanced students.Besides comprehensive cover of structural information gained by electron microscopy, electron cryo-tomography, X-ray crystallography, and nuclear magnetic resonance, this book provides detailed descriptions of mechanistic experiments by single-molecule nanometry. The reports include in vitro studies of the motility of reconstituted complexes and in vivo studies of organisms expressing mutant dyneins. The recent technical improvements described, which have played an important part in recent advances, include the expression and preparation of recombinant dynein heavy chains or individual subdomains.

Produktinformation

Utgivningsdatum2012-02-22
Mått152 x 229 x 26 mm
Vikt680 g
FormatInbunden
SpråkEngelska
Antal sidor404
FörlagPan Stanford Publishing Pte Ltd
ISBN9789814303330

Tillhör följande kategorier

Biologi inom Naturvetenskap och teknik
Teknik: allmänt inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik
Miljöteknik inom Naturvetenskap och teknik

Dyneins: Ancient Protein Complexes Gradually Reveal Their Secrets,. Two Decades of Cytoplasmic Dynein: From Fast to Forceful. Functional Analysis of the Dynein Motor Domain. Structural Studies on the Dynein Heavy Chain. Structural Analysis of Microtubule-Bound Dynein. The Dynein Stalk: Atomic Structure and Roles in the Mechanism of the Dynein Motor. Enzymatic and Motile Properties of Native Dynein Molecules. Motile Properties of Cytoplasmic Dynein. Motile Properties of Inner Arm Dynein. Dynein Motility in Cilia and Flagella. 3D Structures of Axonemes, T. IshikawaFunctional Diversity of Axonemal Dyneins. Assembly and Regulation of Dynein Light Chains. Regulatory Subunits of Axonemal Dynein. The Role of Dynein in Yeast Nuclear Segregation.

"Given the recent explosion of interest in dynein, this book gives a timely review of both historical and current developments in the field. It is an extensive compendium compiled by leading dynein researchers and an excellent resource for young and experienced scientists alike!"—Prof. Joe Howard, Max Planck Institute of Molecular Cell Biology and Genetics, Germany"Handbook of Dynein, edited by the eminent electron microscopists Keiko Hirose and Linda Amos and contributed to by many international leading scientists in the field, is an excellent introduction to cutting-edge dynein research, including such aspects as biochemistry, molecular biology, biophysics, structural biology, and molecular genetics. It introduces not only the mechanisms of how cilia and flagella move and how the intracellular transport is performed by dyneins but also the pathogenesis of diseases related to the dynein motor complex. Thus, it will be a really fine handbook for students and researchers in the broad areas of life sciences."—Prof. Nobutaka Hirokawa, University of Tokyo, Japan