Handbook of Dynein (Second Edition)

Inbunden, Engelska, 2019

AvKeiko Hirose,Japan) Hirose, Keiko (National Institute of Advanced Industrial Science & Technology, Ibaraki

2 469 kr

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Dyneins are molecular motors that are involved in various cellular processes, such as cilia and flagella motility, vesicular transport, and mitosis. Since the first edition of this book was published in 2012, there has been a significant breakthrough: the crystal structures of the motor domains of cytoplasmic dynein have been solved and the previously unknown details of this huge and complex molecule have been unveiled. This new edition contains 14 chapters written by researchers in the US, Europe, and Asia, including 3 new chapters that incorporate new fields. The other chapters have also been substantially updated. Compared with the earlier edition, this book focuses more on the motile mechanisms of dynein, especially by biophysical methods such as cryo-EM, X-ray crystallography, and single-molecule nanometry. It is a major handbook for frontline researchers as well as for advanced students studying cell biology, molecular biology, biochemistry, biophysics, and structural biology.

Produktinformation

Utgivningsdatum2019-05-29
Mått152 x 229 x 28 mm
Vikt453 g
FormatInbunden
SpråkEngelska
Antal sidor436
Upplaga2
FörlagPan Stanford Publishing Pte Ltd
ISBN9789814800013

Tillhör följande kategorier

Tillämpad fysik inom Naturvetenskap och teknik
Biologi inom Naturvetenskap och teknik
Teknik: allmänt inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik

Keiko Hirose is a researcher with more than 30 years’ experience in structural and functional studies of motor proteins. She has a PhD from the University of Tokyo and was a postdoctoral fellow at the University of Pennsylvania and at the MRC Laboratory of Molecular Biology, Cambridge, UK. She is especially interested in how molecular motor proteins, such as dynein, move. Dr. Hirose has been working at the National Institute of Advanced Industrial Science and Technology, Japan, since 1997.

Dyneins: Ancient Protein Complexes Gradually Reveal Their Secrets. Structural and Functional Analysis of the Dynein Motor Domain. Electron Microscopy Studies of Dynein: From Subdomains to Microtubule-Bound Assemblies. Subunit Architecture of the Cytoplasmic Dynein Tail. Measuring the Motile Properties of Single Dynein Molecules. Mechanics of Dynein: Motility. Interactions of Multiple Dynein Motors Studied Using DNA Scaffolding. Cytoplasmic Dynein Force Regulation in Vitro and in Vivo. Dynein in Endosome and Phagosome Maturation. Dynein in Intraflagellar Transport. Diversity of Chlamydomonas Axonemal Dyneins. Motility of Axonemal Dyneins Axonemal Dyneins in Cilia and Flagella. Regulatory Mechanism of Axonemal Dynein.

Given the recent explosion of interest in dynein, this book gives a timely review of both historical and current developments in the field. It is an extensive compendium compiled by leading dynein researchers and an excellent resource for young and experienced scientists alike!Prof. Joe Howard - Max Planck Institute of Molecular Cell Biology and Genetics, GermanyHandbook of Dynein, edited by the eminent electron microscopists Keiko Hirose and Linda Amos and contributed to by many international leading scientists in the field, is an excellent introduction to cutting-edge dynein research, including such aspects as biochemistry, molecular biology, biophysics, structural biology, and molecular genetics. It introduces not only the mechanisms of how cilia and flagella move and how the intracellular transport is performed by dyneins but also the pathogenesis of diseases related to the dynein motor complex. Thus, it will be a really fine handbook for students and researchers in the broad areas of life sciences.Prof. Nobutaka Hirokawa - University of Tokyo, Japan