Handbook of Creatine and Creatinine In Vivo Kinetics

Nyhet

Production, Distribution, Metabolism, and Excretion

Inbunden, Engelska, 2026

3 989 kr

Kommande

The conceptual basis to summarize and predict the in vivo behavior and the related mathematical descriptions and models of creatine and creatinine are currently based on the principles and the methodologies of pharmacokinetics and pharmacodynamics. Most in vivo kinetic analyses and models of creatine and creatinine are assumed linear. The presence of nonlinear in vivo kinetics for creatine are assessed by the author due to the affinity and preferential uptake of the molecule in the muscle. This book is an inquiry into the application of these principles and methodologies for the endogenous compounds creatine and creatinine, and provides new pathways for studies and bench research.

Produktinformation

Utgivningsdatum2026-05-09
Mått156 x 234 x undefined mm
FormatInbunden
SpråkEngelska
Antal sidor312
FörlagTaylor & Francis Ltd
ISBN9781032995274

Tillhör följande kategorier

Farmakologi inom Medicin
Analytisk kemi inom Naturvetenskap och teknik
Biokemi inom Naturvetenskap och teknik

Dr. Mehdi Boroujerdi received his Ph.D. in pharmaceutics and pharmacokinetics with minor in biochemistry from the University of North Carolina at Chapel Hill in 1978. He completed his post-doctoral training at the National Institute of Health, National Institute of Environmental Health Sciences at Research Triangle Park. He served as the professor of pharmaceutics/pharmacokinetics with tenure at Northeastern University, Boston, MA (1982-2002); professor of pharmaceutics and pharmacokinetics at the MCPHS University, School of Pharmacy. Boston, MA (2002-2005); professor of pharmaceutical sciences with tenure at the Albany College of Pharmacy and Health Sciences, Albany, New York (2005-2015 with tenure); and professor of pharmaceutical sciences with tenure at the College of Health Sciences, University of Massachusetts, Lowell, MA (2015-2017). Mehdi Boroujerdi has also served as Dean of School of Pharmacy at Bouvé College of Health Sciences at Northeastern University (1988-1999); as Dean of School of Pharmacy-Boston at MCPHS University (2002-2005); as Dean of Pharmacy and Vice President for Academic Affairs, Provost, at the Albany College of Pharmacy and Health Sciences (2006-2012); and Founding Dean of School of Pharmacy and Pharmaceutical Sciences at the College of Health Sciences, University of Massachusetts at Lowell (2015-2017). He also served as the Dean of Research and Graduate Studies at MCPHS (2003-2005), and Director of Graduate Programs in Biomedical Sciences at Northeastern University (1988-1999).Dr. Mehdi Boroujerdi has 112 peer-reviewed publications; and is the sole author of three books (Pharmacokinetics, Principles and Applications (McGraw Hill, 2002), Pharmacokinetics and Toxicokinetics (CRC Publications, 2015), and Handbook of Pharmacokinetics and Toxicokinetics (CRC Publications, 2023). He has trained many graduate and undergraduate students through his research programs focused on pharmacokinetics and toxicodynamics of anticancer drugs, carcinogenesis, and efflux proteins.He also served as consultant to five pharmaceutical industries.As professor he taught graduate courses in advanced pharmacokinetics and biopharmaceutics, drug metabolism, advanced pharmaceutics, and drug delivery systems, his teaching of undergraduate courses included drug discovery and development, biopharmaceutics and pharmacokinetics, physical pharmacy and pharmaceutics, and pharmacokinetics in disease states.

Chapter 1: Production of Creatine (CR) and Creatinine (Cr). Chapter 2: "In Vivo Distribution of Endogenous Creatine (CR) and Creatinine (Cr)". Chapter 3: Elimination (Metabolism and Excretion) of Creatine (CR) and Creatinine (Cr). Chapter 4: Mathematical Models of Creatine (CR) and Creatinine (Cr) Chapter 5: Creatine (CR) and Creatinine (Cr) as Biological Markers. Chapter 6 Creatine (CR) and Creatinine (Cr) Analytical Methodologies. Chapter 7: Creatine Supplement and Co-Supplements Dosing Regimen, Bioavailability, Influence of Gender and Diet. Chapter 8: Potential Therapeutic Values of Creatine Supplements in Selected Disease States. Chapter 9: Side Effects of Orally Administered Exogenous Creatine. Chapter 10: "Exogenous Creatinine SupplementClinical Application of Creatinine Clearance".