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The earliest application of these models to research on drug mechanisms was in the area of alcohol research. One major thrust of early research was to attempt to explain strain differences in preference as a function of underlying differences in patterns of caloric utilization.
1. The Tools of Pharmacogenetics.- 2. Behavioral Studies of Genetic Differences in Alcohol Action.- 3. Neurochemical Studies of Genetic Differences in Alcohol Action.- 4. Electrophysiological Studies of Genetic Differences in Alcohol Action.- 5. Molecular Biological Approaches to Studies of Alcohol-Metabolizing Enzymes.- 6. Studies of Genetic Differences in Response to Opioid Drugs.- 7. Genetics of Benzodiazepines, Barbiturates, and Anesthetics.- 8. Genetic Differences in Response to Cocaine and Stimulant Drugs.- 9. Genetic Studies of Nicotinic and Muscarinic Agents.- 10. Genetic Differences in the N-Methyl-d-Aspartate Receptor: Effects of Ethanol and Phencyclidine.- 11. Overview.