Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity--the concept that long-term impairments can escape clinical detection--makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: * The biologic basis of neurotoxicity. * Progress in the application of biologic markers. * Reviews of a wide range of in vitro and in vivo testing techniques. * The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. * Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.
Committee on Neurotoxicology and Models for Assessing Risk, Board on Environmental Studies and Toxicology, National Research Council
1 Front Matter; 2 Executive Summary; 3 1. Introduction: Defining the Problem of Neurotoxicity; 4 2. Biologic Basis of Neurotoxicity; 5 3. Biologic Markers in Neurotoxicology; 6 4. Testing for Neurotoxicity; 7 5. Surveillance to Prevent Neurotoxicity in Humans; 8 6. Risk Assessment; 9 7. Conclusions and Recommendations; 10 References; 11 Index
National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Committee on Metagenomics: Challenges and Functional Applications
National Research Council, Division of Behavioral and Social Sciences and Education, Institute of Medicine, and Families Board on Children, Youth, Steve Olson
National Research Council, Division on Earth and Life Studies, Board on Agriculture and Natural Resources, Committee on Animal Nutrition, Subcommittee on Dog and Cat Nutrition
National Research Council, Division on Earth and Life Studies, Board on Agriculture and Natural Resources, Committee on Nutrient Requirements of Horses
National Research Council, Division of Behavioral and Social Sciences and Education, Commission on Behavioral and Social Sciences and Education, and Statistical Sciences Committee on AIDS Research and the Behavioral, Social, Lincoln E. Moses, Heather G. Miller, Charles F. Turner
National Research Council, Division on Earth and Life Studies, Environment and Resources Commission on Geosciences, Board on Environmental Studies and Toxicology, Committee to Review the Outer Continental Shelf Environmental Studies Program, Ecology Panel
National Research Council, Division on Engineering and Physical Sciences, Commission on Engineering and Technical Systems, Committee on Alternative Chemical Demilitarization Technologies
National Research Council, Division on Earth and Life Studies, Environment and Resources Commission on Geosciences, Panel on Effects of Past Global Change on Life
National Research Council, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Exposure Guidance Levels for Selected Hydrofluorocarbons
National Research Council, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Spacecraft Water Exposure Guidelines
National Research Council, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Toxicological Hazard and Risk Assessment
National Research Council, Division on Earth and Life Studies, Environment and Resources Commission on Geosciences, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Research Priorities for Airborne Particulate Matter
National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Commission on Life Sciences, Committee on Risk Assessment of Hazardous Air Pollutants
National Research Council, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Health Effects of Waste Incineration
National Research Council, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Manufactured Vitreous Fibers