Drug Discovery with Privileged Building Blocks

Dr. Jie Jack Li is an established chemist with over 20 years of experience in both medicinal chemistry and process chemistry. He is also widely published as an author or co-author of 34 peer-reviewed articles, 12 patents, and 29 books. Prior to joining ChemPartner, Dr. Li worked at Pfizer, BMS, and Revolution Medicines in oncology, antivirals, metabolic disease, CNS, anti-inflammatory, and dermatology, targeting enzymes, receptors, or ion channels. Dr. Li was also a professor at the University of San Francisco for four years, teaching organic and medicinal chemistry. He earned his Ph.D. from Indiana University and was a post-doctoral fellow at MIT.Dr. Minmin Yang received his PhD in organic synthesis from Auburn University, US in 2001, and did post-doctoral training at the same school from 2002 to 2004. Prior to founding PharmaBlock, he worked with increasing responsibilities from group leader to section head of medicinal chemistry at Roche Palo Alto and Roche China for 4 years. Dr. Yang has authored 80 publications, including 16 international patents.

• Preface 1. Alkynes; 2. Azaindoles; 3. Azetidines; 4. Bicyclic Pyridines Containing Ring-junction N; 5. Bicyclo (1.1.1)pentyl (BCP) as an sp3 Carbon-rich Bioisostere for para-Phenyl and tert-Butyl Groups; 6. Bicyclo[2.2.2]octane (BCO) as A 3D-rich Bioisotere for the para-Phenyl Group; 7. Bicyclo[3.1.0]hexanes; 8. Bridge-Fused Rings as m-Phenyl Bioisosteres; 9. Cubanes, Are We There Yet?; 10. Cyclobutanes; 11. Cyclohexanes; 12. Cyclopentanes; 13. Cyclopropanes as Metabolically More Robust Bioisoteres for Linear Alkyl Substituents; 14. Deazapurines; 15. Furopyridines; 16. Indazoles; 17. Indoles; 18. Oxetanes; 19. Piperidine, the Enchanted Ring; 20. Pyrazines; 21. Pyrazoles; 22. Pyridazines; 23. Pyridines - The Magic of Phenyl-Pyridyl Switch; 24. Pyrimidines; 25. Pyrrolidines; 26. Pyrrolotriazines; 27. Spiroazetidines; 28. Spirocyclic Piperidines; 29. Spirocyclic pyrrolidines; 30. Spirooxetanes; 31. Tetrahydropyrans; 32. Trifluoromethylpyridines. Index