Diagnostic Pathology: Genitourinary

Mahul B. Amin, MD is the returning lead author from the previous edition. He is currently Clinical Professor at the Department of Pathology at the University of Tennessee Health Science Center and the Endowed Chair for Cancer Research and Adjunct Professor, at the Department of Urology, University of Southern California, Keck School of Medicine in Los Angeles, California. His is board certified by the American Board of Pathology in both Anatomic and Clinical Pathology. Dr. Amin was the Editor in Chief of the 8th Edition AJCC TNM Staging Manual, as well as the Editor in Chief of Advances in Anatomic Pathology. His special research interests include urological cancer, quality assurance and improvement, laboratory medicine, and molecular pathology.

• SECTION 1: KIDNEYIntroduction and Overview4 Introduction to Renal Cell TumorsSatish K. Tickoo, MD and Victor E. Reuter, MD10 Classification of Kidney Tumors and Tumor-Like LesionsSatish K. Tickoo, MD and Victor E. Reuter, MDFamilial Cancer Syndromes12 von Hippel-Lindau SyndromeSatish K. Tickoo, MD and Victor E. Reuter, MD16 Birt-Hogg-Dubé SyndromeSatish K. Tickoo, MD and Victor E. Reuter, MD20 Hereditary Leiomyomatosis Renal Cell Carcinoma SyndromeSatish K. Tickoo, MD, Victor E. Reuter, MD, and Mahul B. Amin, MD24 Tuberous Sclerosis ComplexSatish K. Tickoo, MD and Victor E. Reuter, MD28 Succinate Dehydrogenase Complex Deficiency SyndromeSatish K. Tickoo, MD and Victor E. Reuter, MD32 Hereditary Papillary Renal Cancer and Miscellaneous Other Familial Cancer SyndromesSatish K. Tickoo, MD and Victor E. Reuter, MDNonneoplastic Lesions38 Renal Tuberculosis, Xanthogranulomatous Pyelonephritis, Renal MalakoplakiaSatish K. Tickoo, MD and Victor E. Reuter, MDRenal Cell Tumors, Benign44 Papillary AdenomaSatish K. Tickoo, MD and Victor E. Reuter, MD48 Renal OncocytomaSatish K. Tickoo, MD and Victor E. Reuter, MDRenal Cell Carcinoma54 Clear Cell Renal Cell CarcinomaSatish K. Tickoo, MD and Victor E. Reuter, MD64 Multilocular Cystic Renal Neoplasm of Low Malignant PotentialSatish K. Tickoo, MD and Victor E. Reuter, MD68 Clear Cell Renal Cancers With Fibromyomatous Stroma, Including ELOC (Formerly TCEB1) Mutated Renal Cell CarcinomaJudy Sarungbam, MD, Satish K. Tickoo, MD, and Victor E. Reuter, MD74 Clear Cell Papillary Renal Cell TumorSatish K. Tickoo, MD and Victor E. Reuter, MD82 Papillary Renal Cell CarcinomaSatish K. Tickoo, MD and Victor E. Reuter, MD92 Chromophobe Renal Cell CarcinomaSatish K. Tickoo, MD and Victor E. Reuter, MD100 Collecting Duct CarcinomaSatish K. Tickoo, MD and Victor E. Reuter, MD106 SMARCB1-Deficient Renal Medullary Carcinoma and SMARCB1-Deficient Medullary-Like Renal Cell CarcinomaSatish K. Tickoo, MD and Victor E. Reuter, MD112 TFE3- and TFEB-Rearranged Renal Cell CarcinomasSatish K. Tickoo, MD and Victor E. Reuter, MD120 Mucinous Tubular and Spindle Cell CarcinomaSatish K. Tickoo, MD, Yingbei Chen, MD, and Victor E. Reuter, MD126 Tubulocystic Renal Cell CarcinomaSatish K. Tickoo, MD, Judy Sarungbam, MD, and Victor E. Reuter, MD130 Thyroid-Like Follicular Carcinoma of KidneySatish K. Tickoo, MD and Victor E. Reuter, MD134 Acquired Cystic Disease-Associated Renal Cell CarcinomaSatish K. Tickoo, MD and Victor E. Reuter, MD140 Fumarate Hydratase-Deficient Renal Cell CarcinomaJatin S. Gandhi, MD and Mahul B. Amin, MD144 ALK Rearrangement-Associated Renal Cell CarcinomaJatin S. Gandhi, MD and Mahul B. Amin, MD148 Eosinophilic Solid and Cystic Renal Cell CarcinomaJatin S. Gandhi, MD and Mahul B. Amin, MD150 Other Eosinophilic/Oncocytic Tumors, Including ESC, EVT, and LOTSatish K. Tickoo, MD and Victor E. Reuter, MD154 Subsequent 2nd TumorsSatish K. Tickoo, MD and Victor E. Reuter, MD158 Renal Cell Carcinoma, Not Otherwise SpecifiedSatish K. Tickoo, MD and Victor E. Reuter, MDMetanephric Tumors162 Metanephric AdenomaSatish K. Tickoo, MD and Victor E. Reuter, MD168 Metanephric Tumors Other Than Metanephric AdenomaSatish K. Tickoo, MD and Victor E. Reuter, MDNephroblastic Tumors172 Nephrogenic RestsSatish K. Tickoo, MD and Victor E. Reuter, MD176 Nephroblastoma (Wilms Tumor)Satish K. Tickoo, MD and Victor E. Reuter, MD186 Cystic Partially Differentiated NephroblastomaSatish K. Tickoo, MD and Victor E. Reuter, MDMesenchymal Tumors188 AngiomyolipomaSatish K. Tickoo, MD and Victor E. Reuter, MD194 Epithelioid Angiomyolipoma/Epithelioid PEComaSatish K. Tickoo, MD and Victor E. Reuter, MD200 Congenital Mesoblastic NephromaSatish K. Tickoo, MD and Victor E. Reuter, MD204 Clear Cell Sarcoma of KidneySatish K. Tickoo, MD and Victor E. Reuter, MD208 Rhabdoid Tumor of KidneySatish K. Tickoo, MD and Victor E. Reuter, MDMixed Mesenchymal and Epithelial Tumors212 Mixed Epithelial and Stromal Tumor (MEST) Family TumorsSatish K. Tickoo, MD and Victor E. Reuter, MD220 Pediatric Cystic NephromaSatish K. Tickoo, MD and Victor E. Reuter, MD224 Synovial SarcomaSatish K. Tickoo, MD and Victor E. Reuter, MDNeuroendocrine Tumors228 Renal Neuroendocrine Tumor/Carcinoid Tumor and Neuroendocrine CarcinomaSatish K. Tickoo, MD and Victor E. Reuter, MD232 Renal Ewing SarcomaSatish K. Tickoo, MD and Victor E. Reuter, MDHematopoietic Tumors236 Hematopoietic TumorsSatish K. Tickoo, MD, Judy Sarungbam, MD, and Victor E. Reuter, MDMetastatic and Other Tumors242 Juxtaglomerular Cell Tumor (Reninoma)Satish K. Tickoo, MD and Victor E. Reuter, MD246 Renomedullary Interstitial Cell TumorSatish K. Tickoo, MD and Victor E. Reuter, MD250 Other Rare TumorsSatish K. Tickoo, MD and Victor E. Reuter, MD258 Metastatic TumorsSatish K. Tickoo, MD and Victor E. Reuter, MDImmunohistochemical Profiles for Tumors Involving Kidney262 Immunohistochemistry, KidneySatish K. Tickoo, MD and Victor E. Reuter, MDSECTION 2Introduction and Overview270 Classification of Bladder Tumors and Tumor-Like LesionsSteven Christopher Smith, MD, PhDMicroscopic Anatomy272 Microscopic Anatomy of Urinary BladderHikmat Al-Ahmadie, MD and Mahul B. Amin, MD276 Microscopic Anatomy of UrethraHikmat Al-Ahmadie, MD and Mahul B. Amin, MD280 Microscopic Anatomy of UreterSteven Christopher Smith, MD, PhD282 Microscopic Anatomy of Renal PelvisSteven Christopher Smith, MD, PhDNonneoplastic Lesions of Urinary Tract286 Overview of CystitisSteven Christopher Smith, MD, PhD292 Polypoid CystitisSteven Christopher Smith, MD, PhD300 MalakoplakiaSteven Christopher Smith, MD, PhD306 SchistosomiasisSteven Christopher Smith, MD, PhD308 von Brunn NestsSteven Christopher Smith, MD, PhD314 Nephrogenic Adenoma (Metaplasia)Steven Christopher Smith, MD, PhD322 Fibroepithelial PolypSteven Christopher Smith, MD, PhD326 Prostatic-Type Polyp (Ectopic Prostate)Steven Christopher Smith, MD, PhD330 AmyloidosisSteven Christopher Smith, MD, PhD332 Müllerian LesionsSteven Christopher Smith, MD, PhD336 Pseudocarcinomatous HyperplasiaSteven Christopher Smith, MD, PhD344 HamartomaSteven Christopher Smith, MD, PhDUrothelial Neoplasms, General346 Overview of Urinary Bladder NeoplasmsHikmat Al-Ahmadie, MDFlat Urothelial Lesions350 Urothelial Carcinoma In SituSteven Christopher Smith, MD, PhD358 Flat Urothelial Lesions Other Than Carcinoma In SituSteven Christopher Smith, MD, PhDUROTHELIAL NEOPLASMS, NONINVASIVE362 Atypical Urothelial Proliferations, Flat and Tented Type (Formerly Flat and Papillary Hyperplasia)Jatin S. Gandhi, MD and Mahul B. Amin, MD364 Urothelial PapillomaSteven Christopher Smith, MD, PhD370 Papillary Urothelial Neoplasm of Low Malignant PotentialSteven Christopher Smith, MD, PhD374 Low-Grade Papillary Urothelial CarcinomaHikmat Al-Ahmadie, MD378 High-Grade Papillary Urothelial CarcinomaHikmat Al-Ahmadie, MD384 Inverted Urothelial NeoplasiaSteven Christopher Smith, MD, PhDUrothelial Neoplasms, Invasive394 Invasive Urothelial CarcinomaHikmat Al-Ahmadie, MD404 Urothelial Carcinoma, Subtypes and Divergent DifferentiationSteven Christopher Smith, MD, PhDGlandular Lesions426 Cystitis Cystica et GlandularisHikmat Al-Ahmadie, MD430 Villous AdenomaHikmat Al-Ahmadie, MD432 Invasive AdenocarcinomaHikmat Al-Ahmadie, MD438 Clear Cell AdenocarcinomaHikmat Al-Ahmadie, MDSquamous Lesions444 Squamous Proliferations Other Than CarcinomaHikmat Al-Ahmadie, MD448 Invasive Squamous Cell CarcinomaHikmat Al-Ahmadie, MDMesenchymal Lesions454 Myofibroblastic ProliferationsSteven Christopher Smith, MD, PhD462 Smooth Muscle TumorsSteven Christopher Smith, MD, PhD470 RhabdomyosarcomaSteven Christopher Smith, MD, PhD476 Other Mesenchymal TumorsSteven Christopher Smith, MD, PhDOther Tumors of Urinary Bladder484 ParagangliomaSteven Christopher Smith, MD, PhD492 Metastatic/Secondary Involvement of BladderSteven Christopher Smith, MD, PhDDiverticula of Urinary Tract500 DiverticulaHikmat Al-Ahmadie, MD and Mahul B. Amin, MD504 Diverticular-Associated NeoplasiaHikmat Al-Ahmadie, MD and Mahul B. Amin, MDURETHRA508 Inflammatory Lesions of UrethraSteven Christopher Smith, MD, PhD512 Carcinoma of UrethraSteven Christopher Smith, MD, PhD516 Other Tumors and Tumor-Like Lesions of UrethraSteven Christopher Smith, MD, PhDURETER520 Urothelial Carcinoma of UreterHikmat Al-Ahmadie, MD524 Other Tumors and Tumor-Like Lesions of UreterHikmat Al-Ahmadie, MDRENAL PELVIS530 Urothelial Carcinoma of Renal PelvisHikmat Al-Ahmadie, MD540 Other Tumors and Tumor-Like Lesions of Renal elvisHikmat Al-Ahmadie, MDUrachs546 Urachal RemnantsSteven Christopher Smith, MD, PhD548 Tumors of UrachusSteven Christopher Smith, MD, PhDImmunohistochemical Profiles for Tumors Involving Urinary Bladder554 Immunohistochemistry, Urinary TractSteven Christopher Smith, MD, PhDSECTION 3: PROSTATE GLAND AND SEMINAL VESICLEIntroduction and Overview562 Classification of Prostate Tumors and Tumor-Like LesionsGladell P. Paner, MD, (BS) MT564 General Concepts, ProstateGladell P. Paner, MD, (BS) MT570 Microanatomy and Zonal VariationsGladell P. Paner, MD, (BS) MT580 Imaging Considerations for PathologistsSteven Christopher Smith, MD, PhDNONNEOPLASTIC LESIONS584 ProstatitisSteven Christopher Smith, MD, PhD588 Prostate HyperplasiaGladell P. Paner, MD, (BS) MT596 AdenosisHikmat Al-Ahmadie, MD and Mahul B. Amin, MD600 Atrophy and Its PatternsGladell P. Paner, MD, (BS) MT606 Hyperplasia of Mesonephric RemnantsSteven Christopher Smith, MD, PhD610 Verumontanum Mucosal Gland HyperplasiaGladell P. Paner, MD, (BS) MT and Deepika Sirohi, MD612 Nephrogenic Adenoma (Metaplasia) of Prostatic UrethraGladell P. Paner, MD, (BS) MTPUTATIVE PREMALIGNANT LESIONS AND LESIONS FALLING SHORT OF MALIGNANT DIAGNOSIS620 Prostatic Intraepithelial NeoplasiaHikmat Al-Ahmadie, MD and Mahul B. Amin, MDProstate Neoplasms630 General Concepts, Prostate CarcinomaSteven Christopher Smith, MD, PhD638 Acinar AdenocarcinomaGladell P. Paner, MD, (BS) MT656 Acinar Adenocarcinoma Subtypes and PatternsGladell P. Paner, MD, (BS) MT668 Atypical Small Acinar ProliferationsSteven Christopher Smith, MD, PhD674 Intraductal Proliferations and Ductal CarcinomaHikmat Al-Ahmadie, MD and Mahul B. Amin, MD682 Ductal AdenocarcinomaGladell P. Paner, MD, (BS) MT690 Urothelial Carcinoma Involving Prostate GlandSteven Christopher Smith, MD, PhD696 Prostate Carcinoma With Neuroendocrine DifferentiationSteven Christopher Smith, MD, PhD704 Adenoid Cystic (Basal Cell) Carcinoma of ProstateSteven Christopher Smith, MD, PhD710 Sarcomatoid Carcinoma of ProstateSteven Christopher Smith, MD, PhD716 Carcinomas With Squamous DifferentiationGladell P. Paner, MD, (BS) MT722 Cystic Epithelial Tumors of ProstateGladell P. Paner, MD, (BS) MT

"This is the third edition of the genitourinary volume in the popular Diagnostic Pathology series. It is a comprehensive reference and atlas for diseases involving the genitourinary tract. The previous edition was published in 2016." ©Doody's Review Service, 2023, Kyle Perry, MD (Henry Ford Health Systems) Doody's Score: 5 Stars!