Critical Care Nephrology

Dr. Kellum is a Distinguished Professor of Critical Care Medicine, Medicine, Bioengineering and Clinical and Translational Science and holds an Endowed Chair in Critical Care Research from the University of Pittsburgh. He is currently on leave and serving as the Chief Medical Officer for Spectral Medical, a late-stage medical device company developing diagnostics and therapeutics for sepsis. Dr. Kellum received his medical degree from the Medical College of Ohio in 1984. His postgraduate training includes an internship and residency in Internal Medicine at the University of Rochester, NY, and a Fellowship in Critical Care Medicine at the University of Pittsburgh. His research interests span various aspects of Critical Care Medicine but center in critical care nephrology, sepsis, and multi-organ failure. He has authored more than 750 publications, has won several teaching awards teaching, has given more than 500 seminars and invited lectures worldwide.

• Section 1: Principles of Critical CareChapter 1 - The Critically Ill PatientChapter 2 - The Pathophysiologic Foundations of Critical CareChapter 3 - Mechanical VentilationChapter 4 - Hemodynamic Support in the Critically Ill PatientChapter 5 - Monitoring Organ Dysfunction in Critical CareChapter 6 - Kidney-Specific Severity ScoresSection 2: Principles of Renal PhysiologyChapter 7 - The Physiology of the GlomerulusChapter 8 - The Physiology of the Loop of HenleChapter 9 - Glomerular Filtration Rate, Renal Functional Reserve, and Kidney Stress TestingChapter 10 - Renal Energy Consumption and MetabolismSection 3: Epidemiology of Acute Kidney Injury in Critical CareChapter 11 - Acute Kidney Injury: From Clinical to Molecular DiagnosisChapter 12 - Community- and Hospital-Acquired Acute Kidney InjuryChapter 13 - Epidemiology of Acute Kidney Injury in Critically Ill PatientsChapter 14 - Acute Kidney Injury in Patients With Chronic Kidney DiseaseSection 4: Exposures and Patient SusceptibilityChapter 15 - Genetic Predisposition for Acute Kidney Injury (AKI)Chapter 16 - Risk Factors and Risk Assessment in Acute Kidney InjuryChapter 17 - Experimental Models of Acute Kidney InjurySection 5: Humoral and Cellular Mechanisms of Kidney DamageChapter 18 - Renal Blood Flow and Perfusion PressureChapter 19 - Humoral Mediators in SepsisChapter 20 - Cell Death Pathways: Apoptosis and Regulated NecrosisChapter 21 - Pathogen-Associated Molecular Patterns, Damage-Associated Molecular Patterns, and Their Receptors in Acute Kidney InjurySection 6: Clinical Course of Acute Kidney Injury and BiomarkersChapter 22 - Acute Kidney DiseaseChapter 23 - Acute Kidney Disease, Renal Recovery, and Post-Acute Kidney Injury CareChapter 24 - The Role of Biomarkers in the Diagnosis and Management of Acute Kidney InjuryChapter 25 - Functional BiomarkersChapter 26 - Damage BiomarkersChapter 27 - Kidney Stress BiomarkersSection 7: Mechanisms of Repair or ProgressionChapter 28 - Renal Repair and RecoveryChapter 29 - Maladaptive Repair and Progression to CKDChapter 30 - Biomarkers of Recovery and/or Repair Following Acute Kidney InjurySection 8: Renal Histopathology in Acute Kidney InjuryChapter 31 - Practical Considerations of Renal Biopsies in Critical Care PatientsChapter 32 - Localization of Injury and Repair PathwaysSection 9: Imaging Techniques in Critical Care NephrologyChapter 33 - Ultrasonography and Doppler TechniquesChapter 34 - Contrast-Enhanced Renal UltrasoundChapter 35 - Traditional Radiology, Computed Tomography, and Magnetic Resonance Imaging in Critical Care NephrologyChapter 36 - Radionuclides Diagnostic TechniquesSection 10: Clinical Syndromes and Acute Kidney InjuryChapter 37 - Multiple Organ DysfunctionChapter 38 - Acute Kidney Injury in Burns and TraumaChapter 39 - Drug-Induced Acute Kidney InjuryChapter 40 - Acute Kidney Injury in PregnancyChapter 41 - Acute Kidney Injury in Oncology and Tumor Lysis SyndromeChapter 42 - Acute Kidney Injury in Cardiac SurgeryChapter 43 - Acute Kidney Injury in Major SurgeryChapter 44 - Acute Kidney Injury in Heart FailureChapter 45 - Acute Kidney Injury in CirrhosisChapter 46 - Acute Renal Failure in Kidney Transplant RecipientsChapter 47 - Acute GlomerulonephritisChapter 48 - Contrast-Induced Acute Kidney InjuryChapter 49 - Abdominal Compartment SyndromeChapter 50 - Hemolytic Uremic SyndromeSection 11: Prevention and Treatment: General Treatment ConceptsChapter 51 - Nonpharmacologic Management of Acute Renal InjuryChapter 52 - Novel Drugs for Acute Kidney InjuryChapter 53 - Remote Ischemic PreconditioningSection 12: Fluid and ElectrolytesChapter 54 - Blood Biochemistry: Measuring Major Plasma ElectrolytesChapter 55 - Assessment of Urine BiochemistryChapter 56 - Disorders of Sodium and Water BalanceChapter 57 - Disorders of Potassium and MagnesiumChapter 58 - Calcium and Phosphate PhysiologyChapter 59 - Principles of Fluid TherapyChapter 60 - Blood Transfusion TherapyChapter 61 - Loop and Thiazide DiureticsChapter 62 - Vaptans and the Treatment of HyponatremiaChapter 63 - Aldosterone Antagonists, Amiloride, and TriamtereneSection 13: Acid-BaseChapter 64 - Laboratory Tests: Blood Gases, Anion Gap, and Strong Ion GapChapter 65 - Acid-Base Physiology and Diagnosis of DisordersChapter 66 - Metabolic AcidosisChapter 67 - Hyperlactatemia and Lactic AcidosisChapter 68 - Renal Tubular AcidosisChapter 69 - Metabolic AlkalosisChapter 70 - Respiratory Acid-Base DisordersChapter 71 - Iatrogenic and Poison-Derived Acid Base DisordersSection 14: Metabolism and Nutrition in Critical Illness and Acute Kidney InjuryChapter 72 - Energy Requirement and Consumption in the Critically Ill PatientChapter 73 - Impact of Renal Replacement Therapy on Metabolism and Nutrient Requirements in the Critically Ill PatientChapter 74 - Amino Acid Turnover, Protein Metabolism, and Nitrogen Balance in Acute Kidney InjuryChapter 75 - Carbohydrates and LipidsChapter 76 - Endocrinology of the Stress Response During Critical IllnessChapter 77 - Anemia of Critical IllnessChapter 78 - Management of Nutrition in Acute Kidney Injury and Renal Replacement TherapyChapter 79 - Blood Glucose Control in Critical CareChapter 80 - Enteral NutritionSection 15: Infectious Diseases and SepsisChapter 81 - Microbiologic Considerations in the Intensive Care PatientChapter 82 - Innate Immunity and the KidneyChapter 83 - Adaptive Immunity and Critical IllnessChapter 84 - Spontaneous Bacterial Peritonitis and Hepatorenal SyndromeChapter 85 - Tropical Infections Causing Acute Kidney InjuryChapter 86 - Sepsis and Septic ShockChapter 87 - Complement and Its Consequences in SepsisChapter 88 - Coagulation Abnormalities in SepsisDysfunction of the Kidney in SepsisBook chapterFull text accessChapter 89 - Endothelial Dysfunction of the Kidney in SepsisChapter 90 - Sepsis-Induced Acute Kidney InjuryChapter 91 - Recommendations for Sepsis ManagementChapter 92 - Principles of Antimicrobial Prescription in Intensive Care Unit Patients With Acute Kidney InjuryChapter 93 - Renal Replacement Therapy for Septic Acute Kidney InjuryChapter 94 - Blood Purification for SepsisChapter 95 - Management of Infection in Patients With Kidney TransplantChapter 96 - Critical Care Viral InfectionsChapter 97 - Principles of Antibiotic Prescription in Intensive Care Unit Patients and Patients With Acute Renal FailureSection 16: Acute Intoxication and PoisoningChapter 98 - Drugs and Antidotes in Acute IntoxicationChapter 99 - Extracorporeal Therapies in Acute Intoxication and PoisoningChapter 100 - Plasmapheresis in Acute Intoxication and PoisoningChapter 101 - Poisoning: Kinetics to TherapeuticsSection 17: Acute Kidney Injury and Organ CrosstalkChapter 102 - Bleeding and Hemostasis in Acute Renal FailureChapter 103 - Gastrointestinal Problems in Acute Kidney InjuryChapter 104 - Cardiovascular Problems in Acute Kidney InjuryChapter 105 - Water and Electrolyte Disturbances in Acute Renal FailureChapter 106 - Neurologic Problems in Acute Renal FailureChapter 107 - Immunologic and Infectious Complications of Acute Kidney InjuryChapter 108 - Cellular Response to Acute Kidney InjurySection 18: Interaction of the Heart and the KidneyChapter 109 - Heart-Kidney Cross-TalkChapter 110 - Classification of Cardiorenal SyndromeChapter 111 - Cardiorenal Syndrome Type 1Chapter 112 - Cardiorenal Syndrome Type 2Chapter 113 - Cardiorenal Syndrome Type 3Chapter 114 - Cardiorenal Syndrome Type 4Chapter 115 - Cardiorenal Syndrome Type 5Chapter 116 - Renal Function During Cardiac Mechanical Support and Artificial HeartChapter 117 - The Kidney in Diastolic DysfunctionChapter 118 - Principles of Diuretic Management in Heart FailureChapter 119 - Management of Overhydration in Heart Failure PatientsChapter 120 - Recent Advances for Stroke Prevention in Patients With Atrial Fibrillation and Advanced Kidney DiseaseSection 19: Interaction of the Lung and KidneyChapter 121 - Lung-Kidney Cross-TalkChapter 122 - The Kidney During Mechanical VentilationChapter 123 - Extracorporeal Membrane Oxygenation and Renal FunctionChapter 124 - Extracorporeal Carbon Dioxide RemovalChapter 125 - Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy in Adults and ChildrenChapter 126 - Pulmonary-Renal SyndromeSection 20: The Liver and the KidneyChapter 127 - Liver-Kidney InteractionChapter 128 - Pathophysiology and Management of the Hepatorenal SyndromeChapter 129 - Kidney Dysfunction After Liver TransplantationChapter 130 - Extracorporeal Liver Support DevicesSection 21: Interaction of the Brain and the KidneyChapter 131 - Treatment of Combined Acute Renal Failure and Cerebral EdemaChapter 132 - Renal Protection in the Organ DonorChapter 133 - Effect of Extracorporeal Therapies on the BrainSection 22: Fluid Balance and its Management in the Critically IllChapter 134 - Components of Fluid Balance and MonitoringChapter 135 - Noninvasive Methods of Fluid Status Assessment in Critically Ill PatientsChapter 136 - Management of Fluid Overload in Cardiorenal Patients: The Five B ApproachChapter 137 - Mechanical Fluid RemovalSection 23: General Principles of Acute Renal Replacement TherapyChapter 138 - Indications for Renal Replacement Therapy in the Critically IllChapter 139 - Principles of Extracorporeal Circulation and Transport PhenomenaChapter 140 - Membranes and Filters for Use in Acute Renal FailureChapter 141 - Continuous Renal Replacement Therapy Machine TechnologyChapter 142 - Principles of Anticoagulation in Extracorporeal CircuitsChapter 143 - Dialysis Solutions and Replacement FluidsChapter 144 - Starting and Stopping Renal Replacement Therapy in the Critically IllChapter 145 - The Concept of Renal Replacement Therapy Dose and EfficiencyChapter 146 - Quantification of Acute Renal Replacement TherapyChapter 147 - Principles of Pharmacodynamics and Pharmacokinetics of Drugs Used in Extracorporeal TherapiesChapter 148 - Ethical Considerations in Acute Renal Replacement TherapySection 24: Intermittent Renal Replacement TherapiesChapter 149 - Intermittent Techniques for Acute DialysisChapter 150 - Solute and Water Transport in Hemodialysis: Dialyzers, Flow Distribution, and Cross-FiltrationChapter 151 - Biocompatibility of the Dialysis SystemChapter 152 - Composition of Hemodialysis FluidChapter 153 - Indications for and Contraindications to Intermittent Hemodialysis in Critically Ill PatientsChapter 154 - Technical and Clinical Complications of Intermittent Hemodialysis in the Intensive Care UnitChapter 155 - Correction of Water, Electrolyte, and Acid-Base Derangements by Hemodialysis and Derived TechniquesChapter 156 - Urea Kinetics, Efficiency, and Adequacy of Hemodialysis and Other Intermittent TreatmentsChapter 157 - Assessment of Fluid Status and Body Composition and Control of Fluid Balance With Intermittent Hemodialysis in the Critically Ill PatientChapter 158 - Outcomes of Intermittent Hemodialysis in Critically Ill Patients With Acute Kidney InjuryChapter 159 - Hybrid Dialysis Techniques in the Intensive Care UnitChapter 160 - The Role of Plasmapheresis in Critical IllnessChapter 161 - Cascade Filtration for ABO Incompatible TransplantChapter 162 - Nursing Issues and Procedures in Continuous Renal Replacement TherapySection 25: Continuous Renal Replacement Therapies (CRRT)Chapter 163 - Indications for Continuous Renal Replacement Therapy: Renal Replacement Versus Renal SupportChapter 164 - Beginning and Ending Continuous Renal Replacement Therapy in the Intensive Care UnitChapter 165 - Solute and Water Kinetics in Continuous TherapiesChapter 166 - Continuous Renal Replacement Therapy: Modalities and Their SelectionChapter 167 - Vascular Access for Acute Renal Replacement TherapyChapter 168 - Anticoagulation Strategies for Continuous Renal Replacement TherapyChapter 169 - Nursing Strategies to Prevent Coagulation of the Extracorporeal CircuitChapter 170 - Adequacy of Continuous Renal Replacement Therapy: Prescription and DeliveryChapter 171 - High-Volume Hemofiltration in the Intensive Care UnitChapter 172 - Pulse High-Volume Hemofiltration in Management of Critically Ill Patients With Severe Sepsis or Septic ShockChapter 173 - High Cutoff Membranes for Mediators RemovalChapter 174 - Clinical Effects of Continuous Renal Replacement TherapiesChapter 175 - Antibiotic Adjustment in Continuous Renal Replacement TherapyChapter 176 - Nomenclature: Basic PrinciplesChapter 177 - Nomenclature: TechniquesSection 26: Peritoneal Dialysis in the Intensive Care UnitChapter 178 - Peritoneal Dialysis SystemChapter 179 - Indications, Contraindications, and Complications of Peritoneal Dialysis in Acute Renal FailureChapter 180 - Solute and Water Transport Across the Peritoneal BarrierChapter 181 - Choice of Peritoneal Dialysis Technique: Intermittent or ContinuousChapter 182 - Correction of Fluid, Electrolyte, and Acid-Base Derangements by Peritoneal Dialysis in Acute Kidney InjuryChapter 183 - Feasibility, Efficiency, and Adequacy of Peritoneal Dialysis in Acute Kidney InjuryChapter 184 - Clinical Results and Complications of Peritoneal Dialysis in Acute Kidney InjuryChapter 185 - Treatment of Peritonitis and Other Clinical Complications of Peritoneal Dialysis in the Critically Ill PatientChapter 186 - Comparison of Peritoneal Dialysis With Other Treatments for Acute Kidney InjuryChapter 187 - Continuous-Flow Peritoneal Dialysis as Acute TherapyChapter 188 - Nursing and Procedure Issues in Peritoneal DialysisSection 27: Extracorporeal Blood Purification Techniques Beyond DialysisChapter 189 - Sorbents: From Basic Structure to Clinical ApplicationChapter 190 - Therapeutic Apheresis in Critically Ill Patients: Indications, Modalities and Techniques, Clinical ResultsChapter 191 - Extracorporeal Blood Purification Techniques Beyond Dialysis: Coupled Plasmafiltration-AdsorptionChapter 192 - Prometheus SystemChapter 193 - Toraymyxin and Other Endotoxin Adsorption SystemsChapter 194 - Plasmafiltration-Adsorption-Dialysis SystemChapter 195 - Extracorporeal Membrane Oxygenation for Cardiac SupportChapter 196 - Extracorporeal Membrane Oxygenation for Pulmonary SupportChapter 197 - Cell-Based TherapiesSection 28: Critical Care Nephrology in PediatricsChapter 198 - Cellular and Molecular Mechanisms of Acute Kidney InjuryChapter 199 - Epidemiology of Pediatric Acute Kidney InjuryChapter 200 - Treatment of Acute Kidney Injury in Children: Conservative Management to Renal Replacement TherapyChapter 201 - Technical Aspects of Pediatric Continuous Renal Replacement TherapyChapter 202 - Multiple Organ Dysfunction in the Pediatric Intensive Care UnitChapter 203 - Drug Dosing in Pediatric Acute Kidney Insufficiency and Renal Replacement TherapyChapter 204 - Nutrition of Critically Ill Children With Acute Renal FailureChapter 205 - Outcome of Pediatric Acute Kidney InjuryChapter 206 - Renal Replacement Therapy for the Critically Ill InfantChapter 207 - Neonatal Hyperammonemia and Continuous Renal Replacement TherapyChapter 208 - Modified Ultrafiltration in Pediatric Heart SurgeryChapter 209 - Techniques and Machines for Pediatric Renal Replacement TherapyChapter 210 - Antibiotics in Critically Ill Newborns and Children: Nephrotoxicity and Management During Renal Replacement TherapySection 29: Kidney Transplantation and Critical CareChapter 211 - Patient Selection and Pretransplantation Care for Kidney Transplant RecipientsChapter 212 - Kidney Support and Perioperative Care in Kidney TransplantationChapter 213 - Acute Renal Failure in Kidney Transplant RecipientsSection 30: Special Kidney Problems in the Intensive Care UnitChapter 214 - Management of Chronic Kidney Disease and End-Stage Kidney Disease Patients in the Intensive Care UnitChapter 215 - Management of Patients with Diabetes in the Intensive Care UnitChapter 216 - Diagnosis and Management of Acute Kidney Injury in the Emergency DepartmentChapter 217 - Anticancer Drugs and the KidneyChapter 218 - Antiinflammatory Drugs and the KidneyChapter 219 - Calcineurin Inhibitors and Other Immunosuppressive Drugs and the KidneyChapter 220 - Alternative Medicine and Chinese Herbs and the KidneyChapter 221 - Environment, Smoking, Obesity, and the KidneyChapter 222 - Lead and Heavy Metals and the KidneyChapter 223 - Statins and the KidneyChapter 224 - Erythropoietin Therapy in Critically Ill and Acute Kidney Injury PatientsChapter 225 - Vasoactive Drugs, Renal Function, and Acute Kidney InjuryChapter 226 - End Points for Clinical Trials in Acute Kidney InjuryChapter 227 - Hypothermia and the KidneyChapter 228 - Renin-Angiotensin System Blockers and Acute Kidney InjurySection 1: Principles of Critical CareChapter 1 - The Critically Ill PatientChapter 2 - The Pathophysiologic Foundations of Critical CareChapter 3 - Mechanical VentilationChapter 4 - Hemodynamic Support in the Critically Ill PatientChapter 5 - Monitoring Organ Dysfunction in Critical CareChapter 6 - Kidney-Specific Severity ScoresSection 2: Principles of Renal PhysiologyChapter 7 - The Physiology of the GlomerulusChapter 8 - The Physiology of the Loop of HenleChapter 9 - Glomerular Filtration Rate, Renal Functional Reserve, and Kidney Stress TestingChapter 10 - Renal Energy Consumption and MetabolismSection 3: Epidemiology of Acute Kidney Injury in Critical CareChapter 11 - Acute Kidney Injury: From Clinical to Molecular DiagnosisChapter 12 - Community- and Hospital-Acquired Acute Kidney InjuryChapter 13 - Epidemiology of Acute Kidney Injury in Critically Ill PatientsChapter 14 - Acute Kidney Injury in Patients With Chronic Kidney DiseaseSection 4: Exposures and Patient SusceptibilityChapter 15 - Genetic Predisposition for Acute Kidney Injury (AKI)Chapter 16 - Risk Factors and Risk Assessment in Acute Kidney InjuryChapter 17 - Experimental Models of Acute Kidney InjurySection 5: Humoral and Cellular Mechanisms of Kidney DamageChapter 18 - Renal Blood Flow and Perfusion PressureChapter 19 - Humoral Mediators in SepsisChapter 20 - Cell Death Pathways: Apoptosis and Regulated NecrosisChapter 21 - Pathogen-Associated Molecular Patterns, Damage-Associated Molecular Patterns, and Their Receptors in Acute Kidney InjurySection 6: Clinical Course of Acute Kidney Injury and BiomarkersChapter 22 - Acute Kidney DiseaseChapter 23 - Acute Kidney Disease, Renal Recovery, and Post-Acute Kidney Injury CareChapter 24 - The Role of Biomarkers in the Diagnosis and Management of Acute Kidney InjuryChapter 25 - Functional BiomarkersChapter 26 - Damage BiomarkersChapter 27 - Kidney Stress BiomarkersSection 7: Mechanisms of Repair or ProgressionChapter 28 - Renal Repair and RecoveryChapter 29 - Maladaptive Repair and Progression to CKDChapter 30 - Biomarkers of Recovery and/or Repair Following Acute Kidney InjurySection 8: Renal Histopathology in Acute Kidney InjuryChapter 31 - Practical Considerations of Renal Biopsies in Critical Care PatientsChapter 32 - Localization of Injury and Repair PathwaysSection 9: Imaging Techniques in Critical Care NephrologyChapter 33 - Ultrasonography and Doppler TechniquesChapter 34 - Contrast-Enhanced Renal UltrasoundChapter 35 - Traditional Radiology, Computed Tomography, and Magnetic Resonance Imaging in Critical Care NephrologyChapter 36 - Radionuclides Diagnostic TechniquesSection 10: Clinical Syndromes and Acute Kidney InjuryChapter 37 - Multiple Organ DysfunctionChapter 38 - Acute Kidney Injury in Burns and TraumaChapter 39 - Drug-Induced Acute Kidney InjuryChapter 40 - Acute Kidney Injury in PregnancyChapter 41 - Acute Kidney Injury in Oncology and Tumor Lysis SyndromeChapter 42 - Acute Kidney Injury in Cardiac SurgeryChapter 43 - Acute Kidney Injury in Major SurgeryChapter 44 - Acute Kidney Injury in Heart FailureChapter 45 - Acute Kidney Injury in CirrhosisChapter 46 - Acute Renal Failure in Kidney Transplant RecipientsChapter 47 - Acute GlomerulonephritisChapter 48 - Contrast-Induced Acute Kidney InjuryChapter 49 - Abdominal Compartment SyndromeChapter 50 - Hemolytic Uremic SyndromeSection 11: Prevention and Treatment: General Treatment ConceptsChapter 51 - Nonpharmacologic Management of Acute Renal InjuryChapter 52 - Novel Drugs for Acute Kidney InjuryChapter 53 - Remote Ischemic PreconditioningSection 12: Fluid and ElectrolytesChapter 54 - Blood Biochemistry: Measuring Major Plasma ElectrolytesChapter 55 - Assessment of Urine BiochemistryChapter 56 - Disorders of Sodium and Water BalanceChapter 57 - Disorders of Potassium and MagnesiumChapter 58 - Calcium and Phosphate PhysiologyChapter 59 - Principles of Fluid TherapyChapter 60 - Blood Transfusion TherapyChapter 61 - Loop and Thiazide DiureticsChapter 62 - Vaptans and the Treatment of HyponatremiaChapter 63 - Aldosterone Antagonists, Amiloride, and TriamtereneSection 13: Acid-BaseChapter 64 - Laboratory Tests: Blood Gases, Anion Gap, and Strong Ion GapChapter 65 - Acid-Base Physiology and Diagnosis of DisordersChapter 66 - Metabolic AcidosisChapter 67 - Hyperlactatemia and Lactic AcidosisChapter 68 - Renal Tubular AcidosisChapter 69 - Metabolic AlkalosisChapter 70 - Respiratory Acid-Base DisordersChapter 71 - Iatrogenic and Poison-Derived Acid Base DisordersSection 14: Metabolism and Nutrition in Critical Illness and Acute Kidney InjuryChapter 72 - Energy Requirement and Consumption in the Critically Ill PatientChapter 73 - Impact of Renal Replacement Therapy on Metabolism and Nutrient Requirements in the Critically Ill PatientChapter 74 - Amino Acid Turnover, Protein Metabolism, and Nitrogen Balance in Acute Kidney InjuryChapter 75 - Carbohydrates and LipidsChapter 76 - Endocrinology of the Stress Response During Critical IllnessChapter 77 - Anemia of Critical IllnessChapter 78 - Management of Nutrition in Acute Kidney Injury and Renal Replacement TherapyChapter 79 - Blood Glucose Control in Critical CareChapter 80 - Enteral NutritionSection 15: Infectious Diseases and SepsisChapter 81 - Microbiologic Considerations in the Intensive Care PatientChapter 82 - Innate Immunity and the KidneyChapter 83 - Adaptive Immunity and Critical IllnessChapter 84 - Spontaneous Bacterial Peritonitis and Hepatorenal SyndromeChapter 85 - Tropical Infections Causing Acute Kidney InjuryChapter 86 - Sepsis and Septic ShockChapter 87 - Complement and Its Consequences in SepsisChapter 88 - Coagulation Abnormalities in SepsisDysfunction of the Kidney in SepsisBook chapterFull text accessChapter 89 - Endothelial Dysfunction of the Kidney in SepsisChapter 90 - Sepsis-Induced Acute Kidney InjuryChapter 91 - Recommendations for Sepsis ManagementChapter 92 - Principles of Antimicrobial Prescription in Intensive Care Unit Patients With Acute Kidney InjuryChapter 93 - Renal Replacement Therapy for Septic Acute Kidney InjuryChapter 94 - Blood Purification for SepsisChapter 95 - Management of Infection in Patients With Kidney TransplantChapter 96 - Critical Care Viral InfectionsChapter 97 - Principles of Antibiotic Prescription in Intensive Care Unit Patients and Patients With Acute Renal FailureSection 16: Acute Intoxication and PoisoningChapter 98 - Drugs and Antidotes in Acute IntoxicationChapter 99 - Extracorporeal Therapies in Acute Intoxication and PoisoningChapter 100 - Plasmapheresis in Acute Intoxication and PoisoningChapter 101 - Poisoning: Kinetics to TherapeuticsSection 17: Acute Kidney Injury and Organ CrosstalkChapter 102 - Bleeding and Hemostasis in Acute Renal FailureChapter 103 - Gastrointestinal Problems in Acute Kidney InjuryChapter 104 - Cardiovascular Problems in Acute Kidney InjuryChapter 105 - Water and Electrolyte Disturbances in Acute Renal FailureChapter 106 - Neurologic Problems in Acute Renal FailureChapter 107 - Immunologic and Infectious Complications of Acute Kidney InjuryChapter 108 - Cellular Response to Acute Kidney InjurySection 18: Interaction of the Heart and the KidneyChapter 109 - Heart-Kidney Cross-TalkChapter 110 - Classification of Cardiorenal SyndromeChapter 111 - Cardiorenal Syndrome Type 1Chapter 112 - Cardiorenal Syndrome Type 2Chapter 113 - Cardiorenal Syndrome Type 3Chapter 114 - Cardiorenal Syndrome Type 4Chapter 115 - Cardiorenal Syndrome Type 5Chapter 116 - Renal Function During Cardiac Mechanical Support and Artificial HeartChapter 117 - The Kidney in Diastolic DysfunctionChapter 118 - Principles of Diuretic Management in Heart FailureChapter 119 - Management of Overhydration in Heart Failure PatientsChapter 120 - Recent Advances for Stroke Prevention in Patients With Atrial Fibrillation and Advanced Kidney DiseaseSection 19: Interaction of the Lung and KidneyChapter 121 - Lung-Kidney Cross-TalkChapter 122 - The Kidney During Mechanical VentilationChapter 123 - Extracorporeal Membrane Oxygenation and Renal FunctionChapter 124 - Extracorporeal Carbon Dioxide RemovalChapter 125 - Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy in Adults and ChildrenChapter 126 - Pulmonary-Renal SyndromeSection 20: The Liver and the KidneyChapter 127 - Liver-Kidney InteractionChapter 128 - Pathophysiology and Management of the Hepatorenal SyndromeChapter 129 - Kidney Dysfunction After Liver TransplantationChapter 130 - Extracorporeal Liver Support DevicesSection 21: Interaction of the Brain and the KidneyChapter 131 - Treatment of Combined Acute Renal Failure and Cerebral EdemaChapter 132 - Renal Protection in the Organ DonorChapter 133 - Effect of Extracorporeal Therapies on the BrainSection 22: Fluid Balance and its Management in the Critically IllChapter 134 - Components of Fluid Balance and MonitoringChapter 135 - Noninvasive Methods of Fluid Status Assessment in Critically Ill PatientsChapter 136 - Management of Fluid Overload in Cardiorenal Patients: The Five B ApproachChapter 137 - Mechanical Fluid RemovalSection 23: General Principles of Acute Renal Replacement TherapyChapter 138 - Indications for Renal Replacement Therapy in the Critically IllChapter 139 - Principles of Extracorporeal Circulation and Transport PhenomenaChapter 140 - Membranes and Filters for Use in Acute Renal FailureChapter 141 - Continuous Renal Replacement Therapy Machine TechnologyChapter 142 - Principles of Anticoagulation in Extracorporeal CircuitsChapter 143 - Dialysis Solutions and Replacement FluidsChapter 144 - Starting and Stopping Renal Replacement Therapy in the Critically IllChapter 145 - The Concept of Renal Replacement Therapy Dose and EfficiencyChapter 146 - Quantification of Acute Renal Replacement TherapyChapter 147 - Principles of Pharmacodynamics and Pharmacokinetics of Drugs Used in Extracorporeal TherapiesChapter 148 - Ethical Considerations in Acute Renal Replacement TherapySection 24: Intermittent Renal Replacement TherapiesChapter 149 - Intermittent Techniques for Acute DialysisChapter 150 - Solute and Water Transport in Hemodialysis: Dialyzers, Flow Distribution, and Cross-FiltrationChapter 151 - Biocompatibility of the Dialysis SystemChapter 152 - Composition of Hemodialysis FluidChapter 153 - Indications for and Contraindications to Intermittent Hemodialysis in Critically Ill PatientsChapter 154 - Technical and Clinical Complications of Intermittent Hemodialysis in the Intensive Care UnitChapter 155 - Correction of Water, Electrolyte, and Acid-Base Derangements by Hemodialysis and Derived TechniquesChapter 156 - Urea Kinetics, Efficiency, and Adequacy of Hemodialysis and Other Intermittent TreatmentsChapter 157 - Assessment of Fluid Status and Body Composition and Control of Fluid Balance With Intermittent Hemodialysis in the Critically Ill PatientChapter 158 - Outcomes of Intermittent Hemodialysis in Critically Ill Patients With Acute Kidney InjuryChapter 159 - Hybrid Dialysis Techniques in the Intensive Care UnitChapter 160 - The Role of Plasmapheresis in Critical IllnessChapter 161 - Cascade Filtration for ABO Incompatible TransplantChapter 162 - Nursing Issues and Procedures in Continuous Renal Replacement TherapySection 25: Continuous Renal Replacement Therapies (CRRT)Chapter 163 - Indications for Continuous Renal Replacement Therapy: Renal Replacement Versus Renal SupportChapter 164 - Beginning and Ending Continuous Renal Replacement Therapy in the Intensive Care UnitChapter 165 - Solute and Water Kinetics in Continuous TherapiesChapter 166 - Continuous Renal Replacement Therapy: Modalities and Their SelectionChapter 167 - Vascular Access for Acute Renal Replacement TherapyChapter 168 - Anticoagulation Strategies for Continuous Renal Replacement TherapyChapter 169 - Nursing Strategies to Prevent Coagulation of the Extracorporeal CircuitChapter 170 - Adequacy of Continuous Renal Replacement Therapy: Prescription and DeliveryChapter 171 - High-Volume Hemofiltration in the Intensive Care UnitChapter 172 - Pulse High-Volume Hemofiltration in Management of Critically Ill Patients With Severe Sepsis or Septic ShockChapter 173 - High Cutoff Membranes for Mediators RemovalChapter 174 - Clinical Effects of Continuous Renal Replacement TherapiesChapter 175 - Antibiotic Adjustment in Continuous Renal Replacement TherapyChapter 176 - Nomenclature: Basic PrinciplesChapter 177 - Nomenclature: TechniquesSection 26: Peritoneal Dialysis in the Intensive Care UnitChapter 178 - Peritoneal Dialysis SystemChapter 179 - Indications, Contraindications, and Complications of Peritoneal Dialysis in Acute Renal FailureChapter 180 - Solute and Water Transport Across the Peritoneal BarrierChapter 181 - Choice of Peritoneal Dialysis Technique: Intermittent or ContinuousChapter 182 - Correction of Fluid, Electrolyte, and Acid-Base Derangements by Peritoneal Dialysis in Acute Kidney InjuryChapter 183 - Feasibility, Efficiency, and Adequacy of Peritoneal Dialysis in Acute Kidney InjuryChapter 184 - Clinical Results and Complications of Peritoneal Dialysis in Acute Kidney InjuryChapter 185 - Treatment of Peritonitis and Other Clinical Complications of Peritoneal Dialysis in the Critically Ill PatientChapter 186 - Comparison of Peritoneal Dialysis With Other Treatments for Acute Kidney InjuryChapter 187 - Continuous-Flow Peritoneal Dialysis as Acute TherapyChapter 188 - Nursing and Procedure Issues in Peritoneal DialysisSection 27: Extracorporeal Blood Purification Techniques Beyond DialysisChapter 189 - Sorbents: From Basic Structure to Clinical ApplicationChapter 190 - Therapeutic Apheresis in Critically Ill Patients: Indications, Modalities and Techniques, Clinical ResultsChapter 191 - Extracorporeal Blood Purification Techniques Beyond Dialysis: Coupled Plasmafiltration-AdsorptionChapter 192 - Prometheus SystemChapter 193 - Toraymyxin and Other Endotoxin Adsorption SystemsChapter 194 - Plasmafiltration-Adsorption-Dialysis SystemChapter 195 - Extracorporeal Membrane Oxygenation for Cardiac SupportChapter 196 - Extracorporeal Membrane Oxygenation for Pulmonary SupportChapter 197 - Cell-Based TherapiesSection 28: Critical Care Nephrology in PediatricsChapter 198 - Cellular and Molecular Mechanisms of Acute Kidney InjuryChapter 199 - Epidemiology of Pediatric Acute Kidney InjuryChapter 200 - Treatment of Acute Kidney Injury in Children: Conservative Management to Renal Replacement TherapyChapter 201 - Technical Aspects of Pediatric Continuous Renal Replacement TherapyChapter 202 - Multiple Organ Dysfunction in the Pediatric Intensive Care UnitChapter 203 - Drug Dosing in Pediatric Acute Kidney Insufficiency and Renal Replacement TherapyChapter 204 - Nutrition of Critically Ill Children With Acute Renal FailureChapter 205 - Outcome of Pediatric Acute Kidney InjuryChapter 206 - Renal Replacement Therapy for the Critically Ill InfantChapter 207 - Neonatal Hyperammonemia and Continuous Renal Replacement TherapyChapter 208 - Modified Ultrafiltration in Pediatric Heart SurgeryChapter 209 - Techniques and Machines for Pediatric Renal Replacement TherapyChapter 210 - Antibiotics in Critically Ill Newborns and Children: Nephrotoxicity and Management During Renal Replacement TherapySection 29: Kidney Transplantation and Critical CareChapter 211 - Patient Selection and Pretransplantation Care for Kidney Transplant RecipientsChapter 212 - Kidney Support and Perioperative Care in Kidney TransplantationChapter 213 - Acute Renal Failure in Kidney Transplant RecipientsSection 30: Special Kidney Problems in the Intensive Care UnitChapter 214 - Management of Chronic Kidney Disease and End-Stage Kidney Disease Patients in the Intensive Care UnitChapter 215 - Management of Patients with Diabetes in the Intensive Care UnitChapter 216 - Diagnosis and Management of Acute Kidney Injury in the Emergency DepartmentChapter 217 - Anticancer Drugs and the KidneyChapter 218 - Antiinflammatory Drugs and the KidneyChapter 219 - Calcineurin Inhibitors and Other Immunosuppressive Drugs and the KidneyChapter 220 - Alternative Medicine and Chinese Herbs and the KidneyChapter 221 - Environment, Smoking, Obesity, and the KidneyChapter 222 - Lead and Heavy Metals and the KidneyChapter 223 - Statins and the KidneyChapter 224 - Erythropoietin Therapy in Critically Ill and Acute Kidney Injury PatientsChapter 225 - Vasoactive Drugs, Renal Function, and Acute Kidney InjuryChapter 226 - End Points for Clinical Trials in Acute Kidney InjuryChapter 227 - Hypothermia and the KidneyChapter 228 - Renin-Angiotensin System Blockers and Acute Kidney Injury

"This is an excellent source of in-depth information on the intersection between critical illness and nephrology, making it a useful resource for practicing nephrologists or trainees about to enter practice given today's increasing acuity and use of the ICU. The comprehensive review of evidence is well cited, with many chapters written by recognizable field leaders, and well organized into intuitive sections. While it is a large book, its many chapters help compartmentalize information and it would work well as a quick reference guide once readers are familiar with its content. The electronic version is a nice addition and helps readers quickly search its content, but is not required. Overall, this book is an extensive and accessible review of current intensive care nephrology and would serve as an excellent resource for clinicians looking to expand their knowledge on an increasingly common intersection of practice." Reviewed by Paul Adams, BS MD (University of Kentucky College of Medicine) Doody's Score: 93, 4 Stars!