Clinical Xenotransplantation

Pathways and Progress in the Transplantation of Organs and Tissues Between Species

Inbunden, Engelska, 2020

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This title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic.

Produktinformation

Utgivningsdatum2020-09-09
Mått155 x 235 x 23 mm
Vikt731 g
FormatInbunden
SpråkEngelska
Antal sidor306
FörlagSpringer Nature Switzerland AG
ISBN9783030491260

Tillhör följande kategorier

Onkologi inom Medicin
Klinisk medicin och internmedicin inom Medicin
Biologi inom Naturvetenskap och teknik
Kirurgi inom Medicin

Clinical and Experimental Xenotransplantation: Background.- 1. A brief history of clinical cross-species organ xenotransplantation.- 2. The pathobiology of pig-to-primate xenotransplantation: a historical review.- 3. Is sensitization to pig antigens detrimental to subsequent allotransplantation?.- 4. Sensitization to human leukocyte antigens and xenotransplantation?.- Pig Kidney and Heart Xenotransplantation in Nonhuman Primates – the Present Position.- 5. Kidney xenotransplantation in nonhuman primates.- 6. Cardiac xenotransplantation in nonhuman primates.- Organ-source Pig Genetic Engineering and Regulation.- 7. Gene-edited pigs for xenotransplantation.- 8. Addressing regulatory requirements for the organ-source pig – a pragmatic approach to facility design and pathogen prevention.- Antibody-Mediated Allotransplant Rejection: Lessons for Xenotransplantation.- 9. Antibody-mediated graft rejection in nonhuman primate models: comparison of sensitized allotransplant and xenotransplant rejection.- 10. Management of anti-HLA antibodies and acute antibody-mediated rejection.- 11. Evolving approaches to treatment of allosensitization and antibody-mediated rejection.- 12. Lessons from ABO-incompatible cardiac allotransplantation in the newborn.- Patient Evaluation and Selection for First Clinical Trials of Kidney or Heart Xenotransplantation.- 13. Defining an “acceptable risk threshold” – who should be the first kidney xenotransplant recipient?.- 14. Selection of patients for initial clinical trials of kidney xenotransplantation.- 15. Selection of patients for initial clinical trials of cardiac xenotransplantation.- 16. Selection of pediatric patients for initial clinical trials of cardiac xenotransplantation.- 17. Infection in xenotransplantation: organ-source health and patient safety.- 18. Histocompatibility testing for xenotransplantation.- Regulatory, Economic, and Social Aspects of Clinical Trials of Xenotransplantation.- 19. Xenotransplantation; the FDA perspective.- 20. Xenotransplantation: a payer’s perspective.- 21. Public perceptions towards clinical trials of organ xenotransplantation.- Summation.- 22. What did the workshop achieve?