Cell Culture Technology for Pharmaceutical and Cell-Based Therapies

Inbunden, Engelska, 2005

Av Sadettin Ozturk, Wei-Shou Hu, USA) Ozturk, Sadettin (Centocor Inc., Nottingham, Pennsylvania, USA) Hu, Wei-Shou (University of Minnesota, Minneapolis

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Edited by two of the most distinguished pioneers in genetic manipulation and bioprocess technology, this bestselling reference presents a comprehensive overview of current cell culture technology used in the pharmaceutical industry. Contributions from several leading researchers showcase the importance of gene discovery and genomic technology development in the production of biotechnology products, tissue engineering, and cell-based therapies. Offering detailed guidance, they cover the steps leading up to the creation of viable therapies including host cell selection, cloning and gene amplification, bioreactor design and operation, protein purification, optimization, scale-up, and facility design.

Produktinformation

Utgivningsdatum2005-08-30
Mått178 x 254 x 50 mm
Vikt1 620 g
FormatInbunden
SpråkEngelska
SerieBiotechnology and Bioprocessing
Antal sidor786
FörlagTaylor & Francis Inc
ISBN9780824753344

Tillhör följande kategorier

Tillverkningsteknik inom Naturvetenskap och teknik
Biologi inom Naturvetenskap och teknik
Medicin: icke kliniska discipliner inom Medicin
Biokemi inom Naturvetenskap och teknik

Preface. Cell Culture Technology: An Overview. Recombinant DNA Technology and Cell Line Development. Medium Development. Cell Metabolism. Protein Glycosylation. Cell Culture Bioreactors. Aeration, Mixing and Hydrodynamics in Bioreactors. Instrumentation and Process Control. Cell Culture Kinetics and Modeling. Fed-Batch Cultivation Of Mammalian Cells For Production Of Recombinant Proteins. Optimization of High Density Perfusion Bioreactors. Cell Separation And Product Capture. Downstream Processing. Formulation, Finishing, and Packaging. Validation Of Cell Culture Based Processes & Qualification Of Associated Equipment And Facility. Facility Design. Transient Expression of Proteins. Large-Scale Propagation of Insect Cells. Advances In Adult Stem Cell Culture. Ex Vivo Culture Of Hematopoietic And Mesenchymal Stem Cells For Tissue Engineering And Cell-Based Therapies.