Cell-Based Assays Using iPSCs for Drug Development and Testing

Inbunden, Engelska, 2025

Av Carl-Fredrik Mandenius, James A. Ross, James a. Ross

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The book begins with chapters on culture of induced pluripotent stem cells (iPSCs) and iPSC-derived cells with detailed protocols for culturing and differentiation of iPSC-derived endoderm, hepatocytes, vascular endothelial cells, cardiomyocytes, renal podocytes, neurons, and astrocytes.

Produktinformation

Utgivningsdatum2025-05-01
Mått178 x 254 x 21 mm
Vikt734 g
FormatInbunden
SpråkEngelska
SerieMethods in Molecular Biology
Antal sidor271
Upplaga2
FörlagSpringer-Verlag New York Inc.
ISBN9781071645291

Tillhör följande kategorier

Biokemisk teknik inom Naturvetenskap och teknik
Biologi inom Naturvetenskap och teknik
Farmakologi inom Medicin

Cell-Based Assays Using Derived Human Induced Pluripotent Cells in Drug Discovery and Development.- Using Human iPSC-Derived Astrocytes to Investigate Transcription Factor-Driven Astrocyte to Neuron Transdifferentiation.- Human Induced Pluripotent Stem Cell-Derived Definitive Endoderm Bulk Up and Hepatic Differentiation.- One-Step Differentiation of Human Induced Pluripotent Stem Cells into Podocytes.- Human Pluripotent Stem Cell Expansion in Stirred Tank Bioreactors.- Co-Cultures of Human Induced Pluripotent Stem Cell-Derived Neurons, Astrocytes, and Microglia for Modeling Neurodegenerative Diseases.- A Robust Protocol for Pluripotent Stem Cell Modeling of 3D Chamber-Like Cardiac Organoids.- Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelial Cells for the Study of Macular Degeneration.- Human Pluripotent Stem Cell-Derived Endothelial Cells in Disease Modeling and Drug Screening.- Toxicity Testing Using Organoids Made from Human Induced Pluripotent Stem Cells Engineered to Report Oxidative Stress.- Modeling Human Liver Steatosis in Induced Pluripotent Stem Cell-Derived Liver Spheres.- Utility of Induced Pluripotent Stem Cell-Based Microphysiological Systems for Drug Development and Testing.- Compound Testing of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Using Multi-Well Microelectrode Arrays.- Methodology and Practice for Studying Crosstalk between 3D Human Tissue Models in Pneumatically Actuated Multi-Organ-on-Chip Systems.- Spheroid Formation and Easy and Stable Control of Stromal Cells Using Multi-Inlet Spheroid Generator.- Engineered Hydrogels for 3D Cell Culture and Bioprinting of Human Induced Pluripotent Stem Cell-Derived Neuroepithelial Stem Cells.- A Non-Destructive, Image Analysis Method for Evaluating Pigmentation in Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelial Cells.- Evaluating the Effect of Drug Compounds on Cardiac Spheroids Using the Cardiac Cell Outgrowth Assay in a Microphysiological System.- High Content Analysis of Mitochondrial Function in Induced Pluripotent Stem Cell-Derived Neurons.