In this issue of Clinics in Perioperative Nursing Care, guest editors JD Buchert and Elizabeth Pincus bring their considerable expertise to the topic of Caring for Marginalized Patients in the Perioperative Setting. Top experts address the critical issues of bias, discrimination, and inclusivity in surgical settings, exploring how overlapping vulnerabilities such as race, gender, and disability impact patient care, the ethical and legal considerations in caring for marginalized patients, and the importance of inclusive perioperative care and its impact on surgical outcomes.