Breathborne Biomarkers and the Human Volatilome

Häftad, Engelska, 2020

Av Jonathan Beauchamp, Cristina Davis, Joachim Pleil, Germany) Beauchamp, Jonathan (Manager, Emissions Analytics and Diagnostics group, Fraunhofer Institute for Process Engineering and Packaging IVV, Freising, United States) Davis, Cristina (Chair and professor, Department of Mechanical and Aerospace Engineering, University of California, Davis, CA, United States) Pleil, Joachim (Adjunct professor, Department of Environmental Sciences and Engineering, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC

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Breathborne biomarkers carry information on the state of human health, and their role in aiding clinical diagnosis or in therapeutic monitoring has become increasingly important as advances in the field are made. Breathborne Biomarkers and the Human Volatilome, Second Edition, provides a comprehensive update and reworking of the 2013 book Volatile Biomarkers, by Anton Amann and David Smith. The new editing team has expanded this edition beyond volatile organic compounds to cover the broad field of breath analysis, including the many exciting developments that have occurred since the first edition was published. This thoroughly revised volume includes the latest discoveries and applications in breath research from the world's foremost scientists, and offers insights into related future developments. It is an ideal resource for researchers, scientists, and clinicians with an interest in breath analysis.

Presents recent advances in the field of breath analysis
Includes an extensive overview of established biomarkers, detection tools, disease targets, specific applications, data analytics, and study design
Offers a broad treatise of each topic, from basic concepts to a comprehensive review of discoveries, current consensus of understanding, and prospective future developments
Acts as both a primer for beginners and a reference for seasoned researchers

Produktinformation

Utgivningsdatum2020-06-08
Mått191 x 235 x undefined mm
Vikt1 480 g
FormatHäftad
SpråkEngelska
Antal sidor722
Upplaga2
FörlagElsevier Science
ISBN9780128199671

Tillhör följande kategorier

Diagnostiska metoder inom Medicin
Analytisk kemi inom Naturvetenskap och teknik

Jonathan Beauchamp is manager of the Emissions Analytics and Diagnostics group at the Fraunhofer Institute for Process Engineering and Packaging IVV in Freising, Germany. He has been involved in academic and industrial breath research for the past 15 years and is currently principal investigator in several breath-related projects. He is an active member and current treasurer of the International Association of Breath Research (IABR). Cristina Davis is chair and professor of Mechanical and Aerospace Engineering at the University of California Davis, United States. Her research focuses on development of novel chemical and biological sensor systems and biomarker identification in agriculture and human/animal health monitoring. She has 12 issued patents and has coauthored over 100 peer-reviewed journal articles and book chapters. She is current chair-elect of IABR. Joachim Pleil is adjunct professor at the University of North Carolina, School of Public Health, United States. He has published over 150 journal articles, many involving breath biomarker research and statistical interpretation of breath-based data. He has retired from US Environmental Protection Agency after 32 years as a research scientist. He is currently a consultant for NASA on a pilot breathing assessment project and is a founding member of IABR.

ForewordDedicationPrefacePART A: Concepts and modeling1. Breath biomakers and the exposome2. Breath sampling and standardization3. Physiological modeling of exhaled compounds4. Exhaled nitric oxide physiology and modelingPART B: Inorganics and non-volatiles5. Exhaled nitric oxide in clinical practice6. Exhaled carbon monoxide7. Exhaled breath condensate and aerosol8. Exhaled particlesPART C: Analytics9. Selected ion flow tube mass spectrometry10. Proton transfer reaction—mass spectrometry11. Ion mobility spectrometry12. Secondary electrospray ionization13. Sensor systems14. Optical spectroscopy15. Comprehensive gas chromatography-mass spectrometry16. High-resolution mass spectrometryPART D: Breath tests17. 13C breath tests18. Breath monitoring in the intensive care unit19. Chronic obstructive pulmonary disease and smokers20. Clinical phenotyping21. Breath analysis for respiratory infections22. Volatile biomarkers of malaria infection23. Lifestyle applicationsPART E: Beyond human breath24. Biomarkers in urine and stool25. Volatile emissions from skin26. Cell cultures as in vitro models for breath research27. Ruminants28. Breath analysis in marine mammalsPART F: Field applications29. Breath analysis in law enforcement30. Drugs in breath31. Urban search and rescue32. Breath analysis in occupational medicine33. Breath biomarkers in human xenobiotic exposure studies34. Canine olfactionPART G: Design and interpretation35. Clinical study design36. Challenges in clinical breath research development37. Mathematical interpretation of targeted volatilome data38. Preprocessing and analysis of volatilome data39. Applications of the US EPA CompTox Chemicals Dashboard to support mass spectrometry and breath research