Biomarkers for Antioxidant Defense and Oxidative Damage

Principles and Practical Applications

Inbunden, Engelska, 2010

AvGiancarlo Aldini,Kyung-Jin Yeum,Etsuo Niki,Robert M. Russell

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Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications critically evaluates the basic concepts and methodologies of conventional biomarkers as well as current state-of-the-art assays for measuring antioxidant activity/oxidative stress and their practical applications. . Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications will be of a great interest to scientists who are involved in basic research on oxidation, applied scientists evaluating the effects of nutraceuticals or pharmaceutical compounds on antioxidant activity/oxidative stress, and physicians who want to understand the degree of oxidative damage in patients with certain chronic diseases. Discovering sensitive and specific biomarkers for systemic oxidative damage is essential to understand the role of oxidative stress in human disease. Once these roles are clearly understood, we are able to identify novel drug and nutraceutical targets. This volume goes beyond conventional analytical methods of measuring overall antioxidant activity and provides insight to the discovery of biomarkers that reveal information on specific areas of oxidative stress. Contributed by an international list of experts, Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications describes both conventional biomarkers and recent developments in this area.Special Features: Discusses conventional biomarkers as well as recent advances for measuring antioxidants and oxidative stressBiomarkers for lipid peroxidation: isoprostane, hydroxyloctadecaenoic acid, oxysterols, and reactive carbonyl species from lipid peroxidationBiomarkers for protein oxidation: carbonylation, tyrosine oxidation, ubiquitin-conjugationBiomarkers for DNA oxidative damage: comet assay, hydroxylated nucleotides, and exocylcic DNA adductsRecently developed biomarkers from cutting-edge technology

Produktinformation

Utgivningsdatum2010-09-03
Mått180 x 253 x 23 mm
Vikt907 g
FormatInbunden
SpråkEngelska
Antal sidor380
FörlagJohn Wiley and Sons Ltd
ISBN9780813815350

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Giancarlo Aldini, Ph.D., Department of Pharmaceutical Sciences "Pietro Pratesi", Università degli Studi di Milano, Milan, ItalyKyung-Jin Yeum, Ph.D., Jean Mayer USDA-Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.Etsuo Niki, Ph.D., , Health Research Institute, National Institute of Advanced Industrial Science & Technology, Osaka, Japan.Robert M. Russell, M.D., Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Bethesda, MD 20892-7517, USA

Preface viiContributors ix1. Antioxidant Activity and Oxidative Stress: An Overview 3Kyung-Jin Yeum, Robert M. Russell, and Giancarlo Aldini2. Enzymatic Antioxidant Defenses 21Sayuri Miyamoto, Hirofumi Arai, and Junji Terao3. Antioxidants as Biomarkers of Oxidative Stress 35Ikuyo Ichi and Shosuke Kojo4. LDL Oxidation as a Biomarker of Antioxidant Status 51Mohsen Meydani, EunHee Kong, and Ashley Knight5. The Isoprostanes: Accurate Markers and Potent Mediators of Oxidant Injury in Vivo 65Joshua D. Brooks, Brian E. Cox, Klarissa D. Hardy, Stephanie C. Sanchez, Sonia Tourino, Tyler H. Koestner, Jocelyn R. Hyman-Howard, and Ginger L. Milne6. Hydroxyoctadecadienoic Acid (HODE) as a Marker of Linoleic Acid Oxidation 85Yasukazu Yoshida and Etsuo Niki7. Oxysterols: Potential Biomarkers of Oxidative Stress 99Luigi Iuliano and Ulf Diczfalusy8. Lipid Peroxidation Originating α, β-unsaturated Aldehydes and Their Metabolites as Biomarkers 117Françoise Guéraud9. Oxidative Modifi cation of Proteins: An Overview 137Paul J. Thornalley and Naila Rabbani10. Immunochemical Detection of Lipid Peroxidation-specific Epitopes 157Koji Uchida11. Mass Spectrometric Strategies for Identification and Characterization of Carbonylated Peptides and Proteins 173Marina Carini and Marica Orioli12. Nitrotyrosine: Quantitative Analysis, Mapping in Proteins, and Biological Significance 199José M. Souza, Silvina Bartesaghi, Gonzalo Peluffo, and Rafael Radi13. Ubiquitin Conjugates: A Sensitive Marker of Oxidative Stress 219Fu Shang and Allen Taylor14. Covalent Modifications of Albumin Cys34 as a Biomarker of Mild Oxidative Stress 229Giancarlo Aldini, Kyung-Jin Yeum, and Giulio Vistoli15. Protein S-glutathionylation and S-cysteinylation 243Graziano Colombo, Aldo Milzani, Roberto Colombo, and Isabella Dalle-Donne16. DNA Oxidation, Antioxidant Effects, and DNA Repair Measured with the Comet Assay 261Mária Dušinská and Andrew R. Collins17. Hydroxylated Nucleotides: Measurement and Utility as Biomarkers for DNA Damage, Oxidative Stress, and Antioxidant Efficacy 283Phyllis E. Bowen18. Exocyclic DNA Adducts as Biomarkers of Antioxidant Defense and Oxidative Stress 319Roger W.L. GodschalkIndex 333