Are environmental pollutants threatening the human immune system? Researchers are rapidly approaching definitive answers to this question, with the aid of biologic markers--sophisticated assessment tools that could revolutionize detection and prevention of certain diseases. This volume, third in a series on biologic markers, focuses on the human immune system and its response to environmental toxicants. The authoring committee provides direction for continuing development of biologic markers, with strategies for applying markers to immunotoxicology in humans and recommended outlines for clinical and field studies. This comprehensive, up-to-date volume will be invaluable to specialists in toxicology and immunology and to biologists and investigators involved in the development of biologic markers.
Subcommittee on Immunotoxicology, Committee on Biologic Markers, Board on Environmental Studies and Toxicology, National Research Council
1 Front Matter; 2 Summary; 3 1 Introduction; 4 2 The Structure and Function of the Immune System and Mechanisms of Immunotoxicology; 5 3 Biologic Markers for Immune-Mediated Disease; 6 4 Autoimmune Diseases; 7 5 The Capacity of Toxic Agents to Compromise the Immune System (Biologic Markers of Immunosuppression); 8 6 Animal Models for Use in Detecting Immunotoxic Potential and Determining Mechanisms of Action; 9 7 Human Immune-System Biologic Markers of Immunotoxicity; 10 8 Application of Biologic Markers of Immunotoxicity in Epidemiology; 11 9 Use of Biologic Markers in Controversial Areas of Environmental Health; 12 10 Summary and Recommendations; 13 References; 14 Glossary; 15 Biographies; 16 Index
National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Committee on Metagenomics: Challenges and Functional Applications
National Research Council, Division of Behavioral and Social Sciences and Education, Institute of Medicine, and Families Board on Children, Youth, Steve Olson
National Research Council, Division on Earth and Life Studies, Board on Agriculture and Natural Resources, Committee on Animal Nutrition, Subcommittee on Dog and Cat Nutrition
National Research Council, Division on Earth and Life Studies, Board on Agriculture and Natural Resources, Committee on Nutrient Requirements of Horses
National Research Council, Division of Behavioral and Social Sciences and Education, Commission on Behavioral and Social Sciences and Education, and Statistical Sciences Committee on AIDS Research and the Behavioral, Social, Lincoln E. Moses, Heather G. Miller, Charles F. Turner
National Research Council, Division on Earth and Life Studies, Environment and Resources Commission on Geosciences, Board on Environmental Studies and Toxicology, Committee to Review the Outer Continental Shelf Environmental Studies Program, Ecology Panel
National Research Council, Division on Engineering and Physical Sciences, Commission on Engineering and Technical Systems, Committee on Alternative Chemical Demilitarization Technologies
National Research Council, Division on Earth and Life Studies, Environment and Resources Commission on Geosciences, Panel on Effects of Past Global Change on Life
National Research Council, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Exposure Guidance Levels for Selected Hydrofluorocarbons
National Research Council, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Spacecraft Water Exposure Guidelines
National Research Council, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Toxicological Hazard and Risk Assessment
National Research Council, Division on Earth and Life Studies, Environment and Resources Commission on Geosciences, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Research Priorities for Airborne Particulate Matter
National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Commission on Life Sciences, Committee on Risk Assessment of Hazardous Air Pollutants
National Research Council, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Health Effects of Waste Incineration
National Research Council, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Manufactured Vitreous Fibers