Advances in Immunology

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

• Regulation of Immunoglobulin Class Switch Recombination: Choreography of Non-Coding Transcription, Targeted DNA Deamination and Long-Range DNA RepairAllysia Matthews, Simin Zheng, Lauren DiMenna and Jayanta ChaudhuriTwo Forms of Adaptive Immunity in Vertebrates: Similarities and DifferencesMasanori Kasahara and Yoichi SutohRecognition of Tumors by the Innate Immune System and Natural Killer CellsAssaf Marcus, Benjamin G. Gowen, Thornton W. Thompson, Alexandre Iannello, Michele Ardolino, Weiwen Deng, Lin Wang, Nataliya Shifrin and David H. RauletSignaling Circuits in Early B Cell Development Michael Reth and Peter NielsenInterleukin 10 Receptor Signaling: Master Regulator of Intestinal Mucosal Homeostasis in Mice and HumansDror S. Shouval, Jodie Ouahed, Amlan Biswas, Jeremy A. Goettel, Bruce Horwitz, Alexio M. Muise and Scott B. SnapperDevelopment of Mast Cells and Importance of their Tryptase and Chymase Serine Proteases in Inflammation and Wound HealingJeffrey Douaiher, Julien Succar, Luca Lancerotto, Michael F. Gurish, Dennis P. Orgill, Matthew J. Hamilton, Steven A. Krilis and Richard L. StevensWhy does Somatic Hypermutation by AID Require Transcription of its Target Genes?Ursula Storb

"The series which all immunologists need." --The Pharmaceutical Journal"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods