Acquired Long QT Syndrome

Inbunden, Engelska, 2004

Av A. John Camm, Marek Malik, Yee Guan Yap, UK) Camm, A. John (St. George's Hospital Medical School, London, UK) Malik, Marek (St George's Hospital Medical School, London, A John Camm

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In recent years there has been considerable interest in the diagnosis and understanding of ventricular repolarisation, particularly the QT interval prolongation and abnormal T and T/U wave morphology associated with torsades de pointes. Advances in ion channel cloning have greatly improved our understanding of the role of ionic channels in mediating cardiac repolarisation. Unfortunately, it is increasingly recognised that a number of drugs, both those associated with altering repolarisation, and others for non-cardiac conditions can increase the propensity for polymorphic ventricular tachycardia, syncope and even ventricular fibrillation and sudden death. In this volume, arrhythmia specialists from St. George’s Hospital Medical School, London discuss the mechanisms behind QT prolongation and torsades de pointes. They focus particularly on the risk of individual cardiac and non-cardiac drugs in provoking long QT syndrome, providing a comprehensive review which will be useful for all electrophysiologists treating polymorphic ventricular tachycardias, and will expose important regulatory issues for pharmaceutical authorities and for the wider medical community.

Produktinformation

Utgivningsdatum2004-12-01
Mått158 x 231 x 18 mm
Vikt522 g
FormatInbunden
SpråkEngelska
Antal sidor208
FörlagJohn Wiley and Sons Ltd
ISBN9781405118385

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A. John Camm, MD, FRCP, FESC, FACCProfessor of Clinical Cardiology and Head, Department of Cardiological Sciences, St. George’s Hospital Medical School, London Marek Malik, PhD, MD, DSc, FACC, FECSProfessor of Cardiac Electrophysiology, Department of Cardiological Sciences, St. George’s Hospital Medical School, LondonYee Guan Yap, BMedSci, MBBS, MRCPBritish Heart Foundation Research Fellow in Cardiology, Department of Cardiological Sciences, St. George’s Hospital Medical School, London

Preface vi1 Introduction 12 Mechanisms of acquired QT prolongation and torsades de pointes 83 Measurement of the QT interval and repolarization assessment 244 Introduction to drug-induced long QT syndrome 605 Risk of QT prolongation and torsades de pointes with antiarrhythmic drugs 696 Risk of QT prolongation and torsades de pointes with antihistamines 877 Risk of QT prolongation and torsades de pointes with psychotropic drugs 1028 Risk of QT prolongation and torsades de pointes with antimicrobial and antimalarial drugs 1219 Risk of QT prolongation and torsades de pointes with prokinetics and miscellaneous other drugs 14010 Acquired long QT syndrome secondary to cardiac conditions 16311 Acquired long QT syndrome secondary to noncardiac conditions 17112 Perspective on drug-induced repolarization changes 182Index 191