Distinguished Senior Investigator, Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.), Madrid, Spain. Emeritus Professor of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan. Dr Jalife is also actively conducting research at the Centro Nacional de Investigaciones Cardiovasculares, in Madrid, Spain. William Gregory Stevenson, MD, is Professor of Medicine at Vanderbilt University School of Medicine in Nashville, Tennessee. Dr Jalife will assume the role of lead editor on the 8th edition with Douglas Zipes's retirement

• Part I: Structural and Molecular Bases of Ion Channel Function1. Voltage-Gated Sodium Channels and Electrical Excitability of the Heart2. Voltage-Gated Calcium Channels3. Voltage-Gated Potassium Channels4. Molecular Regulation of Cardiac Inward Rectifier Potassium Channel5. Mammalian Calcium Pumps in Health and Disease6. Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function7. Organellar Ion Channels and Transporters8. Molecular Organization, Gating, and Function of Connexin-Based Gap Junction Channels and HemichannelsPart II: Biophysics of Cardiac Ion Channel Function9. Voltage-Gated Sodium Channels with Open and Closed Gates: Implications for State-Dependent Drug Design10. Regulation of Cardiac Calcium Channels11. Molecular Genetics of ATP-Sensitive K+ Channels in Cardiovascular Diseases12. Role of Enhancers in Transcriptional Regulation of Cardiac Electrical Activity13. Notch-Mediated Transcriptional and Epigenetic Regulation of Cardiac Ion Channels14. Stretch-Activated Potassium Channels in the Human Heart: Pathophysiologic and Clinical Significance15. Connexins and Pannexins in Cardiovascular Disease16. Excitation-Contraction CouplingPart III: Intermolecular Interactions and Cardiomyocyte Electrical Function17. Ion Channel Trafficking in the Heart18. Microdomain Interactions of Macromolecular Complexes and Regulation of the Sodium Channel Nav1.519. Connecting Cardiac Excitation to the Atomic Interactions of Ion Channels20. Macromolecular Complexes and Cardiac Potassium Channels21. Reciprocity of Cardiac Sodium and Potassium Channels in the Control of Excitability and Arrhythmias22. The Intercalated Disc: A Molecular Network That Integrates Electrical Coupling, Intercellular Adhesion and Cell Excitability23. Function and Dysfunction of Ion Channel Membrane Trafficking and Post Translational Modification24. Feedback Mechanisms for Cardiac-Specific microRNAs and cAMP Signaling in Electrical RemodelingPart IV: Cell Biology of Cardiac Impulse Initiation and Propagation25. Coupled Oscillators and Sinoatrial Pacemaker Activity26. Optical Mapping of Cardiac Action Potentials in Zebrafish to Assess Genetic Variants27. Cell-to-Cell Communication and Impulse Propagation28. Mechanisms of Normal and Dysfunctional Sinoatrial Nodal Excitability and Propagation29. Cell Biology of the Specialized Cardiac Conduction SystemPart V: Models of Cardiac Excitation30. Prediction of Drug-Induced Arrhythmia Using Machine Learning31. Global Optimization Approaches to Generate Dynamically Robust Electrophysiological Models32. Calcium Signaling in Cardiomyocyte Models with Realistic Geometries33. Theory of Rotors and Arrhythmias34. Distinct ECG Phenotypes Identified in Hypertrophic Cardiomyopathy Using Machine Learning Associate With Arrhythmic Risk Markers35. Computational Approaches for Accurate Rotor localization in the Human Atria36. Modeling the Aging Heart37. Electromechanical Vortex Filaments During Cardiac FibrillationPart VI: Neural Control of Cardiac Electrical Activity38. Innervation of the Sinoatrial Node39. Mechanisms for Altered Autonomic and Oxidant Regulation of Cardiac Sodium Currents40. Neural Activity and Atrial Tachyarrhythmias41. Sympathetic Modulation of Cardiac Electrophysiology42. Role of the Autonomic Nervous System in Atrial FibrillationPart VII: Arrhythmia Mechanisms43. Rotors in Human Atrial Fibrillation44. Nonivasive Frequency-Phase Mapping of Atrial Fibrillation45. Electrical Biomarkers of the Progression of Atrial Fibrillation46. Mechanisms of Human Ventricular Tachycardia and Human Ventricular Fibrillation47. Genetics of Atrial FibrillationPart VIII: Molecular Genetics and Pharmacogenomics48. Mechanisms in Heritable Sodium Channel Diseases49. Genetic, Ionic and Cellular Mechanisms Underlying the J Wave Syndromes50. Inheritable Potassium Channel Diseases51. Inheritable Phenotypes Associated With Altered Intracellular Calcium RegulationPart IX: Pharmacologic, Genetic, and Cell Therapy of Ion Channel Dysfunction52. Upstream therapy to prevent AF progression53. Pharmacogenomics of Cardiac Arrhythmias54. Screening Drugs for Myocardial Disease in Vivo with Zebrafish55. Gene Therapy for Atrial FibrillationPart X: Cell biology and electrophysiology of human induced pluripotent stem cell derived cardiomyocytes56. Cardiac Remodeling and Regeneration57. High-Throughput Optical Mapping of 2 and 3-Dimensional hiPSC-CM Platforms for Drug Discovery and Cardiotoxicity Testing58. Functional Cardiac Fibroblasts Derived from Human Pluripotent Stem Cells via Second Heart Field Progenitors59. Functional Co-Culture of Sympathetic Neurons and Cardiomyocytes Derived from Human-Induced Pluripotent Stem CellsPart XI: Diagnostic Evaluation60. Assessment of the Patient With a Cardiac Arrhythmia61. Differential Diagnosis of Narrow and Wide Complex Tachycardias62. Electrocardiographic Monitoring: Short, Long-Term Recording63. Personal Cardiac Monitoring64. Computed Tomography for Electrophysiology65. Magnetic Resonance Imaging for Electrophysiology66. Intracardiac Echocardiography for Electrophysiology67. Autonomic Nervous System Assessment for Syncope and Arrhythmia Risk68. Non-invasive Electrocardiographic Imaging of Arrhythmogenic Substrates and Arrhythmias69. Genetic TestingPart XII: Supraventricular Arrhythmias: Diagnosis and Therapy70. Supraventricular Tachycardias: Diagnostic Maneuvers in the Electrophysiology Laboratory71. Atrial Tachycardia72. Atrioventricular Nodal Reentrant Tachycardia73. Junctional Tachycardia74. Preexcitation, Atrioventricular Reentry, Variants75. Atrial Fibrillation: Mechanisms, Clinical Features, and Management76. Ablation for Atrial Fibrillation77. Left Atrial Appendage Management78. Typical and Atypical Atrial Flutter: Mapping and AblationPart XIII: Ventricular Arrhythmias79. Sudden Cardiac Death in Adults80. Premature Ventricular Complexes81. Outflow Tract Ventricular Tachyarrhythmias: Mechanisms, Clinical Features, and Management82. PVC Ablation with Anatomic Guidance: Papillary Muscle, Moderator Band and Valve Annulus Sites83. Fascicular Ventricular Arrhythmias84. Bundle Branch Reentry Tachycardia85. Ventricular Arrhythmias in Ischemic Heart Disease86. Ablation of Post-Myocardial Infarction VT87. Ventricular Tachycardia in Patients with Dilated Cardiomyopathy88. Lamin A/C, Noncompaction and Other Genetic Cardiomyopathies with Ventricular Arrhythmias89. Ventricular Arrhythmias in Hypertrophic Cardiomyopathy: Sudden Death, Risk Stratification, and Prevention With Implantable Defibrillators90. Ventricular Tachycardias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy91. Catecholaminergic Polymorphic Ventricular Tachycardia92. Arrhythmias and Conduction Disturbances in Noncompaction Cardiomyopathy93. Ventricular Arrhythmias in Takotsubo Cardiomyopathy94. Mitral Valve Prolapse, ventricular arrhythmias and Sudden Death95. Brugada Syndrome96. Long and Short QT Syndromes97. Andersen-Tawil Syndrome98. Timothy Syndrome99. J-Wave Syndromes100. Idiopathic Ventricular Fibrillation101. Mapping and Ablation of Ventricular Fibrillation102. Drug-Induced Ventricular ArrhythmiasPart XIV: Syncope and Bradyarrhythmias103. Syncope104. Sinus Node Abnormalities105. Postural Orthostatic Tachycardia Syndrome106. Atrioventricular BlockPart XV: Arrhythmias in Special Populations107. Sex Differences in Arrhythmias108. Sudden Cardiac Deaths in Athletes, Including Commotio Cordis109. Cardiac Sarcoidosis110. Sleep-Disordered Breathing and Arrhythmias111. Ventricular Assist Devices and Cardiac Transplantation Recipients112. Arrhythmia in Neurologic Disease113. Cancer Therapy Related ArrhythmiasPart XVI: Congenital Heart Disease and Pediatrics114. Arrhythmias in the Pediatric Population115. Supraventricular Tachycardias in Congenital Heart Disease116. Ventricular Arrhythmias in Congenital Heart DiseasePart XVII: Pharmacologic Therapy117. Antiarrhythmic Drugs118. Impact of Nontraditional Antiarrhythmic Drugs on Sudden Cardiac Death119. Oral AnticoagulantsPart XVIII: Devices for Arrhythmia Management120. Implantable Pacemakers121. Implantable Cardioverter Defibrillators: Technical Aspects122. Implantable Cardioverter Defibrillators: Clinical Aspects123. Subcutaneous Implantable Cardioverter Defibrillators124. Wearable Defibrillators125. Cardiac Resynchronization Therapy126. Management of Implanted Device InfectionsPart XIX: Catheter and Surgical Mapping and Ablation127. Electrogram Recording and Signal Processing128. Electroanatomic Mapping for Arrhythmias129. Mapping Scar-Related Arrhythmias130. Radiofrequency Ablation131. Cryoablation and Other Radiofrequency Alternatives132. Transvascular Ethanol Ablation133. Stereotactic Radioablation134. Percutaneous Epicardial Access, Mapping and Ablation135. Surgery for Atrial Fibrillation and Other Supraventricular Tachycardias136. Surgery for Ventricular Arrhythmias137. Neuromodulation for the Treatment of Arrhythmias

Review of the previous edition: "The quality of the content of this book is excellent. Given the complexity of the subject manner, this book is a valuable resource for cardiologists and cardiology fellows with a specific interest in electrophysiology, as well as for electrophysiologists and electrophysiology fellows to further their knowledge and understanding of the complex topic of electrophysiology. The book is organized in a way that allows readers to develop an advancing framework that enables them to build upon and better grasp more advanced topics. The eighth edition provides updated knowledge and treatment strategies based on up-to-date research that was not in the previous edition." --©Doody’s Review Service, 2022, Matthew Alan Colna, MD (East Tennessee State University Quillen College of Medicine) Doody's Score: 5 Stars!